Mydgf promotes Cardiomyocyte proliferation and Neonatal Heart regeneration

Yuyao Wang(Chinese Academy of Medical Sciences & Peking Union Medical College), Yan Li(Shanxi Medical University), Jie Feng(Chinese Academy of Medical Sciences & Peking Union Medical College), Weijing Liu(Shanxi Medical University), Yandong Li(Chinese Academy of Medical Sciences & Peking Union Medical College), Jun Liu(Shanxi Medical University), Qianqian Yin(Chinese Academy of Medical Sciences & Peking Union Medical College), Hong Lian(Chinese Academy of Medical Sciences & Peking Union Medical College), Lihui Liu(Chinese Academy of Medical Sciences & Peking Union Medical College), Yu Nie(Chinese Academy of Medical Sciences & Peking Union Medical College)
Theranostics
January 1, 2020
10.7150/thno.44281
Cited by 95Open Access
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Abstract

Mydgf promotes cardiomyocyte proliferation by activating c-Myc/FoxM1 pathway and improves heart regeneration both in neonatal and adult mice after cardiac injury, providing a potential target to reverse cardiac remodeling and heart failure.

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