METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications
Dongdong Jian, Ying Wang, Liguo Jian(Second Affiliated Hospital of Zhengzhou University), Hao Tang(Henan Provincial People's Hospital), Lixin Rao, Ke Chen, Zhen Jia, Wanjun Zhang(Henan Provincial People's Hospital), Yiran Liu(Henan Provincial People's Hospital), Chen Xu, Xiwen Shen, Chuanyu Gao, Shuai Wang(Westlake University), Muwei Li
Cited by 283Open Access
Abstract
A modification and inducing endothelial cell inflammatory response as well as atherosclerotic plaque formation. Decreased expression of METTL14 can inhibit endothelial inflammation and atherosclerosis development. Therefore, METTL14 may serve as a potential target for the clinical treatment of atherosclerosis.
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