Engineering a far-red light–activated split-Cas9 system for remote-controlled genome editing of internal organs and tumors
Yuanhuan Yu(East China Normal University), Xin Wu(East China Normal University), Ningzi Guan(East China Normal University), Jiawei Shao(East China Normal University), Huiying Li(East China Normal University), Yuxuan Chen(Zhejiang University), Ping Yuan(Zhejiang University), Dali Li(East China Normal University), Haifeng Ye(East China Normal University)
Cited by 119Open Access
Abstract
oncogene in a mouse xenograft tumor model. Beyond extending the spectrum of light energies in optogenetic toolbox for CRISPR-Cas9 technologies, this study demonstrates how FAST system can be deployed for programmable deep tissue gene editing in both biological and biomedical contexts toward high precision and spatial specificity.
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