Author response: Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

Yohei Ohashi(MRC Laboratory of Molecular Biology), Shirley Tremel(MRC Laboratory of Molecular Biology), Glenn R. Masson(MRC Laboratory of Molecular Biology), Lauren McGinney(MRC Laboratory of Molecular Biology), Jérôme Boulanger(MRC Laboratory of Molecular Biology), Ksenia Rostislavleva(MRC Laboratory of Molecular Biology), Christopher M. Johnson(MRC Laboratory of Molecular Biology), Izabella Niewczas(Babraham Institute), Jonathan Clark(Babraham Institute), Roger Williams(MRC Laboratory of Molecular Biology)
Unknown
May 29, 2020
10.7554/elife.58281.sa2
Cited by 1Open Access
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Abstract

The lipid kinase VPS34 complexes I and II are both activated by unsaturation of substrate and non-substrate lipids, curvature, electrostatics and polyphosphoinositides, which play roles in localisation and cellular function.

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