Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans

Urszula Cytlak; Anastasia Resteu; Sarah Pagan; Kile Green; Paul Milne; Sheetal Maisuria; David McDonald; Gillian Hulme; Andrew Filby; Benjamin Carpenter; Rachel Queen; Sophie Hambleton; Rosie Hague; Hana Lango Allen; James Thaventhiran; Gina M. Doody; Matthew Collin; Venetia Bigley

doi:10.1016/j.immuni.2020.07.003

Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans

Urszula Cytlak(Newcastle University), Anastasia Resteu(Newcastle University), Sarah Pagan(Newcastle University), Kile Green(Newcastle University), Paul Milne(Newcastle University), Sheetal Maisuria(University of Leeds), David McDonald(Newcastle University), Gillian Hulme(Newcastle University), Andrew Filby(Newcastle University), Benjamin Carpenter(Centre for Human Genetics), Rachel Queen(Newcastle University), Sophie Hambleton(Newcastle upon Tyne Hospitals NHS Foundation Trust), Rosie Hague(Royal Hospital for Children), Hana Lango Allen(University of Cambridge), James Thaventhiran(University of Cambridge), Gina M. Doody(University of Leeds), Matthew Collin(Newcastle upon Tyne Hospitals NHS Foundation Trust), Venetia Bigley(Newcastle upon Tyne Hospitals NHS Foundation Trust)

Immunity

July 30, 2020

10.1016/j.immuni.2020.07.003

Cited by 242Open Access

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Abstract

pre-DCs mapped exclusively to the DC2 pathway. In keeping with their lower requirement for IRF8, DC3s expand to replace DC2s in human partial IRF8 deficiency.

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