Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies
Christopher O. Barnes(California Institute of Technology), Anthony P. West(California Institute of Technology), Kathryn E. Huey‐Tubman(California Institute of Technology), Magnus A. G. Hoffmann(California Institute of Technology), Naima G. Sharaf(California Institute of Technology), Pauline R. Hoffman(California Institute of Technology), Nicholas Koranda(California Institute of Technology), Harry B. Gristick(California Institute of Technology), Christian Gaebler(Rockefeller University), Frauke Muecksch(Rockefeller University), Julio C. C. Lorenzi(Rockefeller University), Shlomo Finkin(Rockefeller University), Thomas Hägglöf(Rockefeller University), Arlene Hurley(Rockefeller University Hospital), Katrina G. Millard(Rockefeller University), Yiska Weisblum(Rockefeller University), Fabian Schmidt(Rockefeller University), Théodora Hatziioannou(Rockefeller University), Paul D. Bieniasz(Rockefeller University), Marina Caskey(Rockefeller University), Davide F. Robbiani(Rockefeller University), Michel C. Nussenzweig(Howard Hughes Medical Institute), Pamela J. Björkman(California Institute of Technology)
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Abstract
and RBD epitopes on SARS-CoV-2 spike. Moreover, a 3.4 Å cryo-electron microscopy (cryo-EM) structure of a neutralizing monoclonal Fab-spike complex revealed an epitope that blocks ACE2 receptor binding. Modeling based on these structures suggested different potentials for inter-spike crosslinking by IgGs on viruses, and characterized IgGs would not be affected by identified SARS-CoV-2 spike mutations. Overall, our studies structurally define a recurrent anti-SARS-CoV-2 antibody class derived from VH3-53/VH3-66 and similarity to a SARS-CoV VH3-30 antibody, providing criteria for evaluating vaccine-elicited antibodies.
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