Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury

Yuhei Kirita(Washington University in St. Louis), Hao Wu(Washington University in St. Louis), Kohei Uchimura(Washington University in St. Louis), Parker C. Wilson(Washington University in St. Louis), Benjamin D. Humphreys(Washington University in St. Louis)
Proceedings of the National Academy of Sciences
June 22, 2020
10.1073/pnas.2005477117
Cited by 619Open Access
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Abstract

Significance Single nucleus RNA sequencing revealed gene expression changes during repair after acute kidney injury. We describe a small population of proximal tubule cells that fail to repair (FR-PTCs). Since this subpopulation expresses abundant proinflammatory and profibrotic genes, it may represent a new therapeutic target to improve repair and reduce fibrosis after AKI.

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