The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin

Shuai Xia(Fudan University), Qiaoshuai Lan(Fudan University), Shan Su(Fudan University), Xinling Wang(Fudan University), Wei Xu(Fudan University), Zezhong Liu(Fudan University), Yun Zhu(Chinese Academy of Sciences), Qian Wang(Shanghai Medical College of Fudan University), Lu Lu(Shanghai Medical College of Fudan University), Shibo Jiang(Shanghai Medical College of Fudan University)
Signal Transduction and Targeted Therapy
June 12, 2020
10.1038/s41392-020-0184-0
Cited by 363Open Access
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Abstract

Dear Editor, The rapid spread of SARS-CoV-2 (also known as 2019-nCoV and HCoV-191), a novel lineage B betacoronavirus (βCoV), has caused a global pandemic of coronavirus disease (COVID-19). It has been speculated that RRAR, a unique furin-like cleavage site (FCS) in the spike protein (S), which is absent in other lineage B βCoVs, such as SARS-CoV, is responsible for its high infectivity and transmissibility.2

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