Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

Marijana Vujković; Jacob M. Keaton; Julie A. Lynch; Donald R. Miller; Jin Zhou; Catherine Tcheandjieu; Jennifer E. Huffman; Themistocles L. Assimes; Kimberly Lorenz; Xiang Zhu; Austin T. Hilliard; Renae Judy; Jie Huang; Kyung Min Lee; Derek Klarin; Saiju Pyarajan; John Danesh; Olle Melander; Asif Rasheed; Nadeem Hayat Mallick; Shahid Hameed; Irshad Hussain Qureshi; Muhammad Afzal; Uzma Malik; Anjum Jalal; Shahid Abbas; Xin Sheng; Long Gao; Klaus H. Kaestner; Katalin Suszták; Yan V. Sun; Scott L. DuVall; Kelly Cho; Jennifer S. Lee; J. Michael Gaziano; Lawrence S. Phillips; James B. Meigs; Peter D. Reaven; Peter W.F. Wilson; Todd L. Edwards; Daniel J. Rader; Scott M. Damrauer; Christopher J. O’Donnell; Philip S. Tsao; Mark A. Atkinson; Al C. Powers; Ali Naji; Klaus H. Kaestner; Gonçalo R. Abecasis; Aris Baras; Michael Cantor; Giovanni Coppola; Aris N. Economides; Luca A. Lotta; John D. Overton; Jeffrey G. Reid; Alan R. Shuldiner; Christina Beechert; Caitlin Forsythe; Erin D. Fuller; Zhenhua Gu; Michael Lattari; Alexander Lopez; Thomas D. Schleicher; Maria Sotiropoulos Padilla; Karina Toledo; Louis Widom; Sarah E. Wolf; Manasi Pradhan; Kia Manoochehri; Ricardo H. Ulloa; Xiaodong Bai; Suganthi Balasubramanian; Leland Barnard; Andrew Blumenfeld; Gisu Eom; Lukas Habegger; Alicia Hawes; Shareef Khalid; Evan K. Maxwell; William Salerno; Jeffrey Staples; Ashish Yadav; Marcus B. Jones; Lyndon J. Mitnaul; VA Million Veteran Program; Samuel M. Aguayo; Sunil K. Ahuja; Zuhair K. Ballas; Sujata Bhushan; Edward J. Boyko; David Cohen; John Concato; Joseph I. Constans; Louis J. Dell’Italia; Joseph Fayad; Ronald Fernando; Hermes Flórez; Melinda A. Gaddy; Saib Gappy; Gretchen Gibson; Michael Godschalk; Jennifer A. Greco; Samir Gupta; Salvador Gutierrez; Kimberly Hammer; Mark B. Hamner; John B. Harley; Adriana M. Hung; Mostaqul Huq; Robin A. Hurley; Pran Iruvanti; Douglas Ivins; Frank J. Jacono; Darshana Jhala; Laurence S. Kaminsky; Scott Kinlay; Jon B. Klein; Suthat Liangpunsakul; Jack Lichy; Stephen Mastorides; Roy O. Mathew; Kristin Mattocks; Rachel McArdle; Paul N. Meyer; Laurence J. Meyer; Jonathan P. Moorman; Timothy R. Morgan; Maureen Murdoch; Xuan‐Mai T. Nguyen; Olaoluwa Okusaga; Krisann K. Oursler; Nora Ratcliffe; Michael Rauchman; R. Brooks Robey; George Ross; Richard J. Servatius; Satish Sharma; Scott E. Sherman; Elif Sonel; Peruvemba Sriram; Todd Stapley; Rob Striker; Neeraj Tandon; Gerardo Villareal; Agnes Wallbom; John M. Wells; Jeff Whittle; Mary A. Whooley; Junzhe Xu; Shing‐Shing Yeh; Michaela Aslan; Jessica V. Brewer; Mary T. Brophy; Todd Connor; Dean P. Argyres; Nhan Do; Elizabeth R. Hauser; Donald E. Humphries; Luis E. Selva; Shahpoor Shayan; Brady Stephens; Stacey B. Whitbourne; Hongyu Zhao; Jennifer Moser; Jean C. Beckham; Jim Breeling; Jonathan Romero; Grant D. Huang; Rachel Ramoni; Saiju Pyarajan; Yan V. Sun; Kelly Cho; Peter W.F. Wilson; Christopher J. O’Donnell; Philip S. Tsao; Kyong‐Mi Chang; J. Michael Gaziano; Sumitra Muralidhar; Kyong‐Mi Chang; Benjamin F. Voight; Danish Saleheen

doi:10.1038/s41588-020-0637-y

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

Marijana Vujković(Philadelphia VA Medical Center), Jacob M. Keaton(VA Tennessee Valley Healthcare System), Julie A. Lynch(University of Massachusetts Lowell), Donald R. Miller(University of Massachusetts Lowell), Jin Zhou(University of Arizona), Catherine Tcheandjieu(VA Palo Alto Health Care System), Jennifer E. Huffman(VA Boston Healthcare System), Themistocles L. Assimes(VA Palo Alto Health Care System), Kimberly Lorenz(Translational Therapeutics (United States)), Xiang Zhu(VA Palo Alto Health Care System), Austin T. Hilliard(VA Palo Alto Health Care System), Renae Judy(Philadelphia VA Medical Center), Jie Huang(Peking University), Kyung Min Lee(VA Salt Lake City Healthcare System), Derek Klarin(Broad Institute), Saiju Pyarajan(Brigham and Women's Hospital), John Danesh(University of Cambridge), Olle Melander(Lund University), Asif Rasheed(Center for Non-Communicable Diseases), Nadeem Hayat Mallick(Punjab Institute of Cardiology), Shahid Hameed(Punjab Institute of Cardiology), Irshad Hussain Qureshi(King Edward Medical University), Muhammad Afzal(King Edward Medical University), Uzma Malik(King Edward Medical University), Anjum Jalal(University of Faisalabad), Shahid Abbas(University of Faisalabad), Xin Sheng(University of Pennsylvania), Long Gao(University of Pennsylvania), Klaus H. Kaestner(University of Pennsylvania), Katalin Suszták(University of Pennsylvania), Yan V. Sun(Emory University), Scott L. DuVall(University of Utah), Kelly Cho(Brigham and Women's Hospital), Jennifer S. Lee(VA Palo Alto Health Care System), J. Michael Gaziano(Brigham and Women's Hospital), Lawrence S. Phillips(Emory University), James B. Meigs(Broad Institute), Peter D. Reaven(University of Arizona), Peter W.F. Wilson(Emory University), Todd L. Edwards(Nashville VA Medical Center), Daniel J. Rader(University of Pennsylvania), Scott M. Damrauer(Philadelphia VA Medical Center), Christopher J. O’Donnell(VA Boston Healthcare System), Philip S. Tsao(VA Palo Alto Health Care System), Mark A. Atkinson(University of Florida), Al C. Powers(Vanderbilt University), Ali Naji(University of Pennsylvania), Klaus H. Kaestner(University of Pennsylvania), Gonçalo R. Abecasis(Regeneron (United States)), Aris Baras(Regeneron (United States)), Michael Cantor(Regeneron (United States)), Giovanni Coppola(Regeneron (United States)), Aris N. Economides(Regeneron (United States)), Luca A. Lotta(Regeneron (United States)), John D. Overton(Regeneron (United States)), Jeffrey G. Reid(Regeneron (United States)), Alan R. Shuldiner(Regeneron (United States)), Christina Beechert(Regeneron (United States)), Caitlin Forsythe(Regeneron (United States)), Erin D. Fuller(Regeneron (United States)), Zhenhua Gu(Regeneron (United States)), Michael Lattari(Regeneron (United States)), Alexander Lopez(Regeneron (United States)), Thomas D. Schleicher(Regeneron (United States)), Maria Sotiropoulos Padilla(Regeneron (United States)), Karina Toledo(Regeneron (United States)), Louis Widom(Regeneron (United States)), Sarah E. Wolf(Regeneron (United States)), Manasi Pradhan(Regeneron (United States)), Kia Manoochehri(Regeneron (United States)), Ricardo H. Ulloa(Regeneron (United States)), Xiaodong Bai(Regeneron (United States)), Suganthi Balasubramanian(Regeneron (United States)), Leland Barnard(Regeneron (United States)), Andrew Blumenfeld(Regeneron (United States)), Gisu Eom(Regeneron (United States)), Lukas Habegger(Regeneron (United States)), Alicia Hawes(Regeneron (United States)), Shareef Khalid(Regeneron (United States)), Evan K. Maxwell(Regeneron (United States)), William Salerno(Regeneron (United States)), Jeffrey Staples(Regeneron (United States)), Ashish Yadav(Regeneron (United States)), Marcus B. Jones(Regeneron (United States)), Lyndon J. Mitnaul(Regeneron (United States)), VA Million Veteran Program(Phoenix VA Health Care System), Samuel M. Aguayo(The University of Texas Health Science Center at San Antonio), Sunil K. Ahuja(The University of Texas Health Science Center at San Antonio), Zuhair K. Ballas(VA North Texas Health Care System), Sujata Bhushan(VA Puget Sound Health Care System), Edward J. Boyko(Portland VA Medical Center), David Cohen(Portland VA Medical Center), John Concato(VA Connecticut Healthcare System), Joseph I. Constans(Birmingham VA Medical Center), Louis J. Dell’Italia(Birmingham VA Medical Center), Joseph Fayad(VA Southern Nevada Healthcare System), Ronald Fernando(VA Loma Linda Healthcare System), Hermes Flórez(VA Eastern Kansas Health Care System), Melinda A. Gaddy(John D. Dingell VA Medical Center), Saib Gappy(John D. Dingell VA Medical Center), Gretchen Gibson(Hunter Holmes McGuire VA Medical Center), Michael Godschalk(Hunter Holmes McGuire VA Medical Center), Jennifer A. Greco(VA San Diego Healthcare System), Samir Gupta(Edward Hines, Jr. VA Hospital), Salvador Gutierrez(Edward Hines, Jr. VA Hospital), Kimberly Hammer(Ralph H. Johnson VA Medical Center), Mark B. Hamner(Ralph H. Johnson VA Medical Center), John B. Harley(VA Tennessee Valley Healthcare System), Adriana M. Hung(VA Tennessee Valley Healthcare System), Mostaqul Huq(W. G. (Bill) Hefner VA Medical Center), Robin A. Hurley(W. G. (Bill) Hefner VA Medical Center), Pran Iruvanti(Hampton VA Medical Center), Douglas Ivins(VA Northeast Ohio Healthcare System), Frank J. Jacono(VA Northeast Ohio Healthcare System), Darshana Jhala(New York/New Jersey VA Health Care Network), Laurence S. Kaminsky(VA Boston Healthcare System), Scott Kinlay(VA Boston Healthcare System), Jon B. Klein(Richard L. Roudebush VA Medical Center), Suthat Liangpunsakul(Richard L. Roudebush VA Medical Center), Jack Lichy(James A. Haley Veterans' Hospital), Stephen Mastorides(James A. Haley Veterans' Hospital), Roy O. Mathew(Columbia VA Health Care System), Kristin Mattocks(Bay Pines VA Healthcare System), Rachel McArdle(Bay Pines VA Healthcare System), Paul N. Meyer(VA Salt Lake City Healthcare System), Laurence J. Meyer(VA Salt Lake City Healthcare System), Jonathan P. Moorman(James H. Quillen VA Medical Center), Timothy R. Morgan(Minneapolis VA Health Care System), Maureen Murdoch(VA Boston Healthcare System), Xuan‐Mai T. Nguyen(Michael E. DeBakey VA Medical Center), Olaoluwa Okusaga(Michael E. DeBakey VA Medical Center), Krisann K. Oursler(Salem VA Medical Center), Nora Ratcliffe(Manchester VA Medical Center), Michael Rauchman(White River Junction VA Medical Center), R. Brooks Robey(VA Pacific Islands Health Care System), George Ross(SUNY Upstate Medical University), Richard J. Servatius(SUNY Upstate Medical University), Satish Sharma(VA NY Harbor Healthcare System), Scott E. Sherman(VA NY Harbor Healthcare System), Elif Sonel(North Florida/South Georgia Veterans Health System), Peruvemba Sriram(MaineHealth), Todd Stapley(MaineHealth), Rob Striker(Overton Brooks VA Medical Center), Neeraj Tandon(Overton Brooks VA Medical Center), Gerardo Villareal(New Mexico VA Health Care System), Agnes Wallbom(Edith Nourse Rogers Memorial Veterans Hospital), John M. Wells(Edith Nourse Rogers Memorial Veterans Hospital), Jeff Whittle(Milwaukee VA Medical Center), Mary A. Whooley(VA Western New York Healthcare System), Junzhe Xu(VA Western New York Healthcare System), Shing‐Shing Yeh(VA Connecticut Healthcare System), Michaela Aslan(VA Boston Healthcare System), Jessica V. Brewer(VA Boston Healthcare System), Mary T. Brophy(VA Boston Healthcare System), Todd Connor(Raymond G. Murphy VA Medical Center), Dean P. Argyres(VA Boston Healthcare System), Nhan Do(VA Boston Healthcare System), Elizabeth R. Hauser(VA Boston Healthcare System), Donald E. Humphries(VA Boston Healthcare System), Luis E. Selva(VA Boston Healthcare System), Shahpoor Shayan(VA Boston Healthcare System), Brady Stephens(VA Boston Healthcare System), Stacey B. Whitbourne(VA Boston Healthcare System), Hongyu Zhao(VA Connecticut Healthcare System), Jennifer Moser(Durham VA Medical Center), Jean C. Beckham(VA Boston Healthcare System), Jim Breeling(VA Boston Healthcare System), Jonathan Romero(VA Boston Healthcare System), Grant D. Huang(VA Boston Healthcare System), Rachel Ramoni(Harvard University), Saiju Pyarajan(Brigham and Women's Hospital), Yan V. Sun(Brigham and Women's Hospital), Kelly Cho(Brigham and Women's Hospital), Peter W.F. Wilson(Harvard University), Christopher J. O’Donnell(Stanford University), Philip S. Tsao(The University of Texas Health Science Center at San Antonio), Kyong‐Mi Chang(Brigham and Women's Hospital), J. Michael Gaziano(Brigham and Women's Hospital), Sumitra Muralidhar(The University of Texas Health Science Center at San Antonio), Kyong‐Mi Chang(The University of Texas Health Science Center at San Antonio), Benjamin F. Voight(Columbia University Irving Medical Center), Danish Saleheen(Columbia University Irving Medical Center)

Nature Genetics

June 15, 2020

10.1038/s41588-020-0637-y

Cited by 792Open Access

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