Discovery of Aptamers Targeting the Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein
Yanling Song(Xiamen University), Jia Song(Shanghai Jiao Tong University), Xinyu Wei(Xiamen University), Mengjiao Huang(Xiamen University), Miao Sun(Xiamen University), Lin Zhu(Xiamen University), Bingqian Lin(Xiamen University), Haicong Shen(Xiamen University), Zhi Zhu(Xiamen University), Chaoyong Yang(Shanghai Jiao Tong University)
Cited by 454Open Access
Abstract
values of the optimized CoV2-RBD-1C and CoV2-RBD-4C aptamers against RBD were 5.8 nM and 19.9 nM, respectively. Simulated interaction modeling, along with competitive experiments, suggests that two aptamers may have partially identical binding sites at ACE2 on SARS-CoV-2 RBD. These aptamers present an opportunity for generating new probes for recognition of SARS-CoV-2 and could provide assistance in the diagnosis and treatment of SARS-CoV-2 while providing a new tool for in-depth study of the mechanisms behind the coronavirus infection.
Related Papers
No related papers found
Powered by citation graph analysis