Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth
Sarah Davidson(University of Cambridge), Mirjana Efremova(Wellcome Sanger Institute), Angela Riedel(University of Cambridge), Bidesh Mahata(University of Cambridge), Jhuma Pramanik(Wellcome Sanger Institute), Jani Huuhtanen(University of Helsinki), Gozde Kar(Wellcome Sanger Institute), Roser Vento‐Tormo(Wellcome Sanger Institute), Tzachi Hagai(Tel Aviv University), Xi Chen(Wellcome Sanger Institute), Muzlifah Haniffa(Newcastle University), Jacqueline D. Shields(University of Cambridge), Sarah A. Teichmann(University of Cambridge)
Cited by 326Open Access
Abstract
macrophages, and perturbation of C3a and C3aR disrupts immune infiltration, slowing tumor growth. Our results highlight the power of scRNA-seq to identify complex interplays and increase stromal diversity as a tumor develops, revealing that stromal cells acquire the capacity to modulate immune landscapes from early disease.
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