DNA vaccine protection against SARS-CoV-2 in rhesus macaques
Jingyou Yu(Beth Israel Deaconess Medical Center), Lisa H. Tostanoski(Beth Israel Deaconess Medical Center), Lauren Peter(Beth Israel Deaconess Medical Center), Noe B. Mercado(Beth Israel Deaconess Medical Center), Katherine McMahan(Beth Israel Deaconess Medical Center), Shant H. Mahrokhian(Beth Israel Deaconess Medical Center), Joseph P. Nkolola(Beth Israel Deaconess Medical Center), Jinyan Liu(Beth Israel Deaconess Medical Center), Zhenfeng Li(Beth Israel Deaconess Medical Center), Abishek Chandrashekar(Beth Israel Deaconess Medical Center), David R. Martinez(University of North Carolina at Chapel Hill), Carolin Loos(Ragon Institute of MGH, MIT and Harvard), Caroline Atyeo(Ragon Institute of MGH, MIT and Harvard), Stephanie Fischinger(Ragon Institute of MGH, MIT and Harvard), John S. Burke(Ragon Institute of MGH, MIT and Harvard), Matthew D. Slein(Ragon Institute of MGH, MIT and Harvard), Yuezhou Chen(Brigham and Women's Hospital), Adam Zuiani(Brigham and Women's Hospital), Felipe Lelis(Brigham and Women's Hospital), Meghan Travers(Brigham and Women's Hospital), Shaghayegh Habibi(Brigham and Women's Hospital), Laurent Pessaint(Bioqual), Alex Van Ry(Bioqual), Kelvin Blade(Bioqual), Renita Brown(Bioqual), Anthony Cook(Bioqual), Brad Finneyfrock(Bioqual), Alan Dodson(Bioqual), Elyse Teow(Bioqual), Jason Velasco(Bioqual), Roland Zahn(Janssen (Netherlands)), Frank Wegmann(Janssen (Netherlands)), Esther A. Bondzie(Beth Israel Deaconess Medical Center), Gabriel Dagotto(Beth Israel Deaconess Medical Center), Makda S. Gebre(Beth Israel Deaconess Medical Center), Xuan He(Beth Israel Deaconess Medical Center), Catherine Jacob-Dolan(Beth Israel Deaconess Medical Center), Marinela Kirilova(Beth Israel Deaconess Medical Center), Nicole Kordana(Beth Israel Deaconess Medical Center), Zijin Lin(Beth Israel Deaconess Medical Center), Lori F. Maxfield(Beth Israel Deaconess Medical Center), Felix Nampanya(Beth Israel Deaconess Medical Center), Ramya Nityanandam(Beth Israel Deaconess Medical Center), John D. Ventura(Beth Israel Deaconess Medical Center), Huahua Wan(Beth Israel Deaconess Medical Center), Yongfei Cai(Boston Children's Hospital), Bing Chen(Boston Children's Hospital), Aaron G. Schmidt(Concord Consortium), Duane R. Wesemann(Brigham and Women's Hospital), Ralph S. Baric(University of North Carolina at Chapel Hill), Galit Alter(Concord Consortium), Hanné Andersen(Bioqual), Mark G. Lewis(Bioqual), Dan H. Barouch(Beth Israel Deaconess Medical Center)
Cited by 1,129Open Access
Abstract
Prototype DNA vaccines for SARS-CoV-2 The development of a vaccine to protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an urgent biomedical need. Yu et al. designed a series of prototype DNA vaccines against the SARS-CoV-2 spike protein, which is used by the virus to bind and invade human cells. Analysis of the vaccine candidates in rhesus macaques showed that animals developed protective humoral and cellular immune responses when challenged with the virus. Neutralizing antibody titers were also observed at levels similar to those seen in humans who have recovered from SARS-CoV-2 infection. Science , this issue p. 806
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