SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area
Dianna Ng(University of California, San Francisco), Gregory M. Goldgof(University of California, San Francisco), Brian R. Shy(University of California, San Francisco), Andrew G. Levine(University of California, San Francisco), Joanna Balcerek(University of California, San Francisco), Sagar P. Bapat(University of California, San Francisco), John C. Prostko(Abbott Fund), Mary A. Rodgers(Abbott Fund), Kelly E. Coller(Abbott Fund), Sandy Pearce(Abbott Fund), Sergej Franz(Pacific Research Institute), Li Du(Pacific Research Institute), Mars Stone(University of California, San Francisco), Satish K. Pillai(Pacific Research Institute), Alicia Sotomayor-González(University of California, San Francisco), Venice Servellita(University of California, San Francisco), Claudia Sanchez San Martin(University of California, San Francisco), Andrea Granados(University of California, San Francisco), Dustin R. Glasner(University of California, San Francisco), Lucy M. Han(University of California, San Francisco), Kent Truong(University of California, San Francisco), Naomi Akagi(University of California, San Francisco), David N. Nguyen(University of California, San Francisco), Neil M. Neumann(University of California, San Francisco), Daniel Qazi(University of California, San Francisco), Elaine Hsu(University of California, San Francisco), Wei Gu(University of California, San Francisco), Yale Santos(University of California, San Francisco), Brian Custer(Pacific Research Institute), Valerie Green, Phillip Williamson, Nancy K. Hills(University of California, San Francisco), Chuanyi M. Lu(University of California, San Francisco), Jeffrey D. Whitman(University of California, San Francisco), Susan L. Stramer(American Red Cross), Candace Wang(University of California, San Francisco), Kevin Reyes(University of California, San Francisco), Jill Hakim, Kirk Sujishi(University of California, San Francisco), Fariba Alazzeh(University of California, San Francisco), Lori Pham(University of California, San Francisco), Ching-Ying Oon(University of California, San Francisco), Steve Miller(University of California, San Francisco), Theodore W. Kurtz(University of California, San Francisco), John Hackett(Abbott Fund), Graham Simmons(University of California, San Francisco), Michael P. Busch(University of California, San Francisco), Charles Y. Chiu(University of California, San Francisco)
Cited by 85Open Access
Abstract
We report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seropositivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors. We additionally describe the longitudinal dynamics of immunoglobulin-G, immunoglobulin-M, and in vitro neutralizing antibody titers in COVID-19 patients. Neutralizing antibodies rise in tandem with immunoglobulin levels following symptom onset, exhibiting median time to seroconversion within one day of each other, and there is >93% positive percent agreement between detection of immunoglobulin-G and neutralizing titers.
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