TARC is a specific and sensitive serum marker for classical Hodgkin’s lymphoma in children
Eline A. M. Zijtregtop(Erasmus MC - Sophia Children’s Hospital), Friederike Meyer‐Wentrup(Princess Máxima Center), W C Wong(Erasmus MC - Sophia Children’s Hospital), Raoull Hoogendijk(Princess Máxima Center), M I Lopez(The Netherlands Cancer Institute), C. Michel Zwaan(Princess Máxima Center), Auke Beishuizen(Princess Máxima Center)
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Abstract
Introduction Pediatric classical Hodgkin’s lymphoma (cHL) is characterized by Hodgkin Reed-Sternberg (HRS) cells located in an inflammatory microenvironment. HRS cells and microenvironment communicate through active crosstalk. This results in secretion of blood biomarkers, which may serve as surrogate markers for lymphoma viability [1], [2]. One promising biomarker in adult patients with cHL is “Thymus and Activation-Regulated Chemokine” (TARC) [3], [4]. So far, TARC levels in pediatric cHL patients have not been reported. The objectives of this study were to investigate TARC as a diagnostic marker in pediatric cHL patients and to define normal TARC values in non-cHL children.
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