Tumor Targeting by α<sub>v</sub>β<sub>3</sub>-Integrin-Specific Lipid Nanoparticles Occurs <i>via</i> Phagocyte Hitchhiking
Alexandros Marios Sofias(Norwegian University of Science and Technology), Yohana C. Toner(Icahn School of Medicine at Mount Sinai), Anu E. Meerwaldt(Utrecht University), Mandy M. T. van Leent(Amsterdam University Medical Centers), Georgios Soultanidis(Icahn School of Medicine at Mount Sinai), Mattijs Elschot(Norwegian University of Science and Technology), Haruki Gonai(Icahn School of Medicine at Mount Sinai), Kristin Grendstad(Norwegian University of Science and Technology), Åsmund Flobak(Norwegian University of Science and Technology), Ulrike Neckmann(Norwegian University of Science and Technology), Camilla Wolowczyk(Norwegian University of Science and Technology), Elizabeth L. Fisher(Icahn School of Medicine at Mount Sinai), Thomas Reiner(Memorial Sloan Kettering Cancer Center), Catharina de Lange Davies(Norwegian University of Science and Technology), Geir Bjørkøy(Norwegian University of Science and Technology), Abraham J. P. Teunissen(Icahn School of Medicine at Mount Sinai), Jordi Ochando(Instituto de Salud Carlos III), Carlos Pérez‐Medina(Spanish National Centre for Cardiovascular Research), Willem J. M. Mulder(Amsterdam University Medical Centers), Sjoerd Hak(SINTEF)
Cited by 113Open Access
Abstract
-integrin-targeted cyclic arginine-glycine-aspartate decorated liposomes and oil-in-water nanoemulsions in tumor mouse models. We observed that ligand-mediated accumulation in cancerous lesions is multifaceted and identified "NP hitchhiking" with phagocytes to contribute considerably to this intricate process. We anticipate that this understanding can facilitate rational improvement of nanomedicine applications and that immune cell-NP interactions can be harnessed to develop clinically viable nanomedicine-based immunotherapies.