Branched chain amino acids exacerbate myocardial ischemia/reperfusion vulnerability via enhancing GCN2/ATF6/PPAR-α pathway-dependent fatty acid oxidation
Yueyang Li(Air Force Medical University), Zhenyu Xiong(Air Force Medical University), Wenjun Yan(Xijing Hospital), Erhe Gao(Temple University), Hexiang Cheng(Xijing Hospital), Guiling Wu(Air Force Medical University), Yi Liu(Xijing Hospital), Ling Zhang(Xijing Hospital), Congye Li(Air Force Medical University), Shan Wang(Xijing Hospital), Miaomiao Fan(Xijing Hospital), Huishou Zhao(Air Force Medical University), Fuyang Zhang(Xijing Hospital), Ling Tao(Air Force Medical University)
Cited by 169Open Access
Abstract
: We identify BCAA as an important nutrition regulator of myocardial fatty acid metabolism through transcriptional upregulation of PPAR-α. Chronic accumulation of BCAA, caused by either dietary or genetic factors, renders the heart vulnerable to I/R injury via exacerbating lipid peroxidation toxicity. These data support the notion that BCAA lowering methods might be potentially effective cardioprotective strategies, especially among patients with diseases characterized by elevated levels of BCAA, such as obesity and diabetes.
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