Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma

Laura Donovan; Alberto Delaidelli; Sujith K. Joseph; Kevin Bielamowicz; Kristen Fousek; Borja Holgado; Alex Manno; Dilakshan Srikanthan; Ahmed Z. Gad; Randy Van Ommeren; David Przelicki; Cory M. Richman; Vijay Ramaswamy; Craig Daniels; Jonelle G. Pallota; Tajana Douglas; Alyssa C. M. Joynt; Joonas Haapasalo; Carolina Nör; Maria Vladoiu; Claudia M. Kuzan-Fischer; Livia Garzia; Stephen C. Mack; Srinidhi Varadharajan; Matthew L. Baker; Liam D. Hendrikse; Michelle Ly; Kaitlin Kharas; Polina Balin; Xiaochong Wu; Lei Qin; Ning Huang; Ana Guerreiro Stücklin; A. Sorana Morrissy; Florence M.G. Cavalli; Betty Luu; Raúl A. Suárez; Pasqualino De Antonellis; Antony Michealraj; Avesta Rastan; Meenakshi Hegde; Martin Komosa; Olga Sirbu; Sachin Kumar; Zied Abdullaev; Cláudia C. Faria; Stephen Yip; Juliette Hukin; Uri Tabori; Cynthia Hawkins; Ken Aldape; Mads Daugaard; John M. Maris; Poul H. Sorensen; Nabil Ahmed; Michael D. Taylor

doi:10.1038/s41591-020-0827-2

Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma

Laura Donovan(Hospital for Sick Children), Alberto Delaidelli, Sujith K. Joseph(Houston Methodist), Kevin Bielamowicz(Houston Methodist), Kristen Fousek(Houston Methodist), Borja Holgado(Hospital for Sick Children), Alex Manno(Hospital for Sick Children), Dilakshan Srikanthan(University of Toronto), Ahmed Z. Gad(Houston Methodist), Randy Van Ommeren(University of Toronto), David Przelicki(University of Toronto), Cory M. Richman(University of Toronto), Vijay Ramaswamy(Hospital for Sick Children), Craig Daniels(Hospital for Sick Children), Jonelle G. Pallota(Hospital for Sick Children), Tajana Douglas(Hospital for Sick Children), Alyssa C. M. Joynt(Hospital for Sick Children), Joonas Haapasalo(Hospital for Sick Children), Carolina Nör(Hospital for Sick Children), Maria Vladoiu(University of Toronto), Claudia M. Kuzan-Fischer(Hospital for Sick Children), Livia Garzia(McGill University Health Centre), Stephen C. Mack(Baylor College of Medicine), Srinidhi Varadharajan(Baylor College of Medicine), Matthew L. Baker(Houston Methodist), Liam D. Hendrikse(University of Toronto), Michelle Ly(University of Toronto), Kaitlin Kharas(University of Toronto), Polina Balin(University of Toronto), Xiaochong Wu(Hospital for Sick Children), Lei Qin(Hospital for Sick Children), Ning Huang(Hospital for Sick Children), Ana Guerreiro Stücklin(Hospital for Sick Children), A. Sorana Morrissy(University of Calgary), Florence M.G. Cavalli(Hospital for Sick Children), Betty Luu(Hospital for Sick Children), Raúl A. Suárez(Hospital for Sick Children), Pasqualino De Antonellis(Hospital for Sick Children), Antony Michealraj(Hospital for Sick Children), Avesta Rastan(Hospital for Sick Children), Meenakshi Hegde(Houston Methodist), Martin Komosa(Hospital for Sick Children), Olga Sirbu(University of Toronto), Sachin Kumar(Hospital for Sick Children), Zied Abdullaev(National Cancer Institute), Cláudia C. Faria(Centro Hospitalar Lisboa Norte), Stephen Yip(University of British Columbia), Juliette Hukin(BC Children's Hospital), Uri Tabori(Hospital for Sick Children), Cynthia Hawkins(Hospital for Sick Children), Ken Aldape(National Cancer Institute), Mads Daugaard(University of British Columbia), John M. Maris(Children's Hospital of Philadelphia), Poul H. Sorensen, Nabil Ahmed(Baylor College of Medicine), Michael D. Taylor(University of Toronto)

Nature Medicine

April 27, 2020

10.1038/s41591-020-0827-2

Cited by 241Open Access

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