Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor

Xiangyu Chen(Army Medical University), Li Ren(Northeast Agricultural University), Zhiwei Pan(Army Medical University), Chunfang Qian(Chongqing Public Health Medical Center), Yang Yang(Army Medical University), Renrong You(China Agricultural University), Jing Zhao(Army Medical University), Pinghuang Liu(China Agricultural University), Leiqiong Gao(Army Medical University), Zhirong Li(Army Medical University), Qizhao Huang(Sichuan Cancer Hospital), Lifan Xu(Army Medical University), Jianfang Tang(Army Medical University), Tian Qin(Army Medical University), Wei Yao(Army Medical University), Hu Li(Army Medical University), Xiaofeng Yan(Chongqing Public Health Medical Center), Xinyuan Zhou(Army Medical University), Yuzhang Wu(Army Medical University), Kai Deng(Sun Yat-sen University), Zheng Zhang(Shenzhen Third People’s Hospital), Zhaohui Qian(Chinese Academy of Medical Sciences & Peking Union Medical College), Yaokai Chen(Chongqing Public Health Medical Center), Lilin Ye(Army Medical University)
Cellular and Molecular Immunology
April 20, 2020
10.1038/s41423-020-0426-7
Cited by 370Open Access
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Abstract

According to the World Health Organization (WHO) newly updated situation report on March 18th, 2020, the coronavirus disease 2019 (COVID-19) pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide. 1 6] Currently, there are no approved prophylactic vaccines or therapeutic drugs that are specific to COVID-19. Blocking monoclonal antibodies (mAbs), due to their extraordinary antigen specificity, are one of the best candidates for neutralizing virus infection. Therefore, identifying and cloning blocking mAbs that can specifically target surface viral proteins to block the viral entry to host cells is a very attractive approach for preventing and treating COVID-19, in particular when effective vaccines and therapeutics are unavailable in the outbreak of the COVID-19 pandemic. We then sought to identify and clone blocking mAbs from the memory B cell repertoire of recently recovered COVID-19 patients to prevent the entry of COVID-19 virus to the host cells.

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