The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution
Orit Rozenblatt–Rosen(Broad Institute), Aviv Regev(Broad Institute), Philipp Oberdoerffer(National Cancer Institute), Tal Nawy(Memorial Sloan Kettering Cancer Center), Anna Hupalowska(Broad Institute), Jennifer Rood(Broad Institute), Orr Ashenberg(Broad Institute), Ethan Cerami(Dana-Farber Cancer Institute), Robert J. Coffey(Vanderbilt University Medical Center), Emek Demir(Oregon Health & Science University), Li Ding(James S. McDonnell Foundation), Edward D. Esplin(Stanford Medicine), James M. Ford(Stanford University), Jeremy Goecks(Oregon Health & Science University), Sharmistha Ghosh(National Cancer Institute), Joe W. Gray(Oregon Health & Science University), Justin Guinney(Sage Bionetworks), Sean E. Hanlon(National Cancer Institute), Shannon K. Hughes(National Cancer Institute), E. Shelley Hwang(Duke University), Christine A. Iacobuzio–Donahue(Memorial Sloan Kettering Cancer Center), Judit Jané‐Valbuena(Broad Institute), Bruce E. Johnson(Brigham and Women's Hospital), Ken S. Lau(Vanderbilt University Medical Center), Tracy Lively(National Cancer Institute), Sarah A. Mazzilli(Boston University), Dana Pe’er(Memorial Sloan Kettering Cancer Center), Sandro Santagata(Brigham and Women's Hospital), Alex K. Shalek(Broad Institute), Denis Schapiro(Broad Institute), M Snyder(Stanford Medicine), Peter K. Sorger(Harvard University), Avrum Spira(Boston University), Sudhir Srivastava(National Cancer Institute), Kai Tan(Children's Hospital of Philadelphia), Robert B. West(Stanford Medicine), Elizabeth H. Williams(Dana-Farber Cancer Institute), Denise R. Aberle, Samuel I. Achilefu, Foluso O. Ademuyiwa, Andrew Adey, Rebecca Aft, Rachana Agarwal, Ruben A. Aguilar, Fatemeh Alikarami, Viola Allaj, Christopher I. Amos, Robert A. Anders(Stanford Medicine), Michael Angelo, Kristen Anton, Orr Ashenberg(Broad Institute), Jon C. Aster, Özgün Babur, Amir Bahmani, Akshay Balsubramani, David Barrett, Jennifer Beane(Broad Institute), Diane E. Bender, Kathrin M. Bernt, Lynne D. Berry, Courtney B. Betts, Julie Bletz, Katie E. Blise, Adrienne Boire, Genevieve M. Boland, Alexander Borowsky, Kristopher R. Bosse, Matthew J. Bott, Ed Boyden(Stanford Medicine), James D. Brooks(Stanford University), Raphael Bueno, Erik A. Burlingame, Qiuyin Cai, Joshua D. Campbell, Wagma Caravan, Ethan Cerami(Dana-Farber Cancer Institute), Hassan Chaı̈b, Joseph M. Chan, Young Hwan Chang, Deyali Chatterjee, Ojasvi Chaudhary, Alyce A. Chen, Bob Chen, Changya Chen, Chia‐Hui Chen, Feng Chen, Yuan Chen, Milan G. Chheda, Koei Chin, Roxanne Chiu, Shih‐Kai Chu, Rodrigo Chuaqui, Jaeyoung Chun, Luis Cisneros, Robert J. Coffey(Vanderbilt University Medical Center), Graham A. Colditz, Kristina A. Cole, Natalie B. Collins, Kévin Contrepois, Lisa M. Coussens, Allison Creason, Daniel Crichton, Christina Curtis, Tanja M. Davidsen, Sherri R. Davies, Ino de Bruijn, Laura DelloStritto, Angelo De Marzo, Emek Demir(Oregon Health & Science University), David G. DeNardo, Dinh Diep, Li Ding(James S. McDonnell Foundation), Sharon J. Diskin, Xengie Doan, Julia L. Drewes, S. Dubinett, Michael A. Dyer(Stanford Medicine), Jacklynn V. Egger, Jennifer Eng(Broad Institute), Barbara E. Engelhardt, Graham S. Erwin, Edward D. Esplin(Stanford Medicine), Laura Esserman, Alex Felmeister(Broad Institute), Heidi S. Feiler, Ryan C. Fields, Stephen Fisher, Keith T. Flaherty, Jennifer Flournoy(Broad Institute), James M. Ford(Stanford University), Angelo Fortunato, Allison Frangieh, Jennifer L. Frye, Robert S. Fulton, Danielle Galipeau, Siting Gan, Jianjiong Gao, Long Gao, Peng Gao, Vianne R. Gao, Tim Geiger, Ajit George, Gad Getz, Sharmistha Ghosh(National Cancer Institute), Marios Giannakis, David L. Gibbs, William E. Gillanders, Jeremy Goecks(Oregon Health & Science University), S. Peter Goedegebuure, Alanna Gould, Kate H.C. Gowers, Joe W. Gray(Oregon Health & Science University), William J. Greenleaf(Dana-Farber Cancer Institute), Jeremy S. Gresham(Oregon Health & Science University), Jennifer L. Guerriero, Tuhin K. Guha, Alexander R. Guimarães, Justin Guinney(Sage Bionetworks), David A. Gutman, Nir Hacohen, Sean E. Hanlon(National Cancer Institute), Casey R. Hansen, Olivier Harismendy, Kathleen A. Harris, Aaron N. Hata, Akimasa Hayashi, Cody N. Heiser, Karla Helvie, John M. Herndon, Gilliam Hirst, F. Stephen Hodi, Travis J. Hollmann, Aaron M. Horning, James J. Hsieh, Shannon Hughes(National Cancer Institute), Won Jae Huh, Stephen P. Hunger, Shelley Hwang(Duke University), Christine A. Iacobuzio–Donahue(Memorial Sloan Kettering Cancer Center), Heba Ijaz, Benjamin Izar, Connor A. Jacobson, Sam M. Janes, Judit Jané‐Valbuena(Broad Institute), Reyka G. Jayasinghe, Lihua Jiang, Brett Johnson(Brigham and Women's Hospital), Bruce E. Johnson(Brigham and Women's Hospital), Tao Ju(Broad Institute), Humam Kadara, Klaus H. Kaestner, Jacob Kagan, Lukas Kalinke, Robert L. Keith(Stanford Medicine), Aziz Khan, Warren A. Kibbe, Albert H. Kim, Erika Kim, Junhyong Kim, Annette Kolodzie, Mateusz Kopytra, Eran Kotler, Robert Krueger(Stanford Medicine), Kostyantyn Krysan, Anshul Kundaje, Uri Ladabaum, Blue B. Lake, Huy Lam, Rozelle Laquindanum, Ken S. Lau(Vanderbilt University Medical Center), Ashley M. Laughney, Hayan Lee, Marc E. Lenburg, Carina A. Leonard, Ignaty Leshchiner, Rochelle Levy, Jerry Li(Dana-Farber Cancer Institute), Christine G. Lian, Kian‐Huat Lim, Jia‐Ren Lin(Stanford Medicine), Yiyun Lin(Stanford Medicine), Qi Liu, Ruiyang Liu, Tracy Lively(National Cancer Institute), William J.R. Longabaugh, Teri A. Longacre, X. Cynthia, Mary C. Macedonia, Tyler Madison, Christopher A. Maher, Anirban Maitra, Netta Mäkinen, Danika Makowski, Carlo C. Maley, Zoltan Maliga, Diego Mallo, John M. Maris(Brigham and Women's Hospital), Nick Markham, Jeffrey R. Marks, Daniel Martínez, R. Jay Mashl(Vanderbilt University Medical Center), Ignas Masilionais, Jennifer L. Mason(Broad Institute), Joan Massagué, Pierre P. Massion, Marissa S. Mattar, Richard Mazurchuk, Linas Mažutis, Sarah A. Mazzilli(Boston University), Eliot T. McKinley, Joshua F. McMichael, Daniel T. Merrick, Matthew Meyerson, Julia R. Miessner, Gordon B. Mills, Meredith Mills, Suman Mondal, Motomi Mori, Yuriko Mori, Elizabeth Moses(Dana-Farber Cancer Institute), Yaël P. Mossé, Jeremy L. Muhlich, Gëorge F. Murphy, Nicholas E. Navin, Tal Nawy(Memorial Sloan Kettering Cancer Center), Michel Nederlof, Reid M. Ness, Stephanie Nevins, Milen Nikolov, Ajit J. Nirmal, Garry P. Nolan, Edward Novikov(Stanford Medicine), Philipp Oberdoerffer(National Cancer Institute), Brendan L. O’Connell, Michael Offin(Stanford Medicine), Stephen T. Oh(Brigham and Women's Hospital), Anastasiya Olson, Alex Ooms(Broad Institute), Miguel Ossandon, Kouros Owzar, Swapnil Parmar, Tasleema Patel, Gary J. Patti, Dana Pe’er(Memorial Sloan Kettering Cancer Center), Itsik Pe'er(Memorial Sloan Kettering Cancer Center), Tao Peng, Daniel Persson, Marvin Petty, Hanspeter Pfister, Kornélia Polyák, Kamyar Esmaeili Pourfarhangi, Sidharth V. Puram, Qi Qiu, Àlvaro Quintanal-Villalonga, Arjun Raj, Marisol Ramirez‐Solano, Rumana Rashid, Ashley N. Reeb, Aviv Regev(Broad Institute), Mary E. Reid, Adam Resnick, Sheila M. Reynolds, Jessica L. Riesterer, Scott J. Rodig, Joseph T. Roland, Sonia Rosenfield, Asaf Rotem, Sudipta Roy, Orit Rozenblatt–Rosen(Broad Institute), Charles M. Rudin, Marc D. Ryser, Sandro Santagata(Brigham and Women's Hospital), Maria Santi-Vicini, Kazuhito Sato, Denis Schapiro(Broad Institute), Deborah Schrag, Nikolaus Schultz, Cynthia L. Sears, Rosalie C. Sears, Subrata Sen(Broad Institute), Triparna Sen(Broad Institute), Alex K. Shalek(Broad Institute), Jeff Sheng, Quanhu Sheng, Kooresh I. Shoghi, Martha J. Shrubsole, Yu Shyr, Alexander B. Sibley, Kiara Siex, Alan J. Simmons, Dinah S. Singer, Shamilene Sivagnanam, Michal Slyper, M Snyder(Stanford Medicine), Artem Sokolov, Sheng-Kwei Song, Peter K. Sorger(Harvard University), Austin N. Southard-Smith, Avrum Spira(Boston University), Sudhir Srivastava(National Cancer Institute), Janet M. Stein, Phillip B. Storm, Elizabeth H. Stover(Dana-Farber Cancer Institute), Siri H. Strand, Timothy Su(National Cancer Institute), Damir Sudar, Ryan J. Sullivan, Lea F. Surrey, Mario L. Suvà, Kai Tan(Children's Hospital of Philadelphia), Nadezhda V. Terekhanova, Luke Ternes, Lisa Thammavong, Guillaume Thibault, George Thomas, Vésteinn Thórsson, Ellen Todres, Linh M. Tran, Madison Tyler, Yasin Uzun, Anil Vachani, Eliezer M. Van Allen, Simon Vandekar, Deborah J. Veis, Sébastien Vigneau, Arastoo Vossough, Angela J. Waanders, Nikhil Wagle, Liang-Bo Wang(Duke University), Michael C. Wendl, Robert B. West(Stanford Medicine), Elizabeth H. Williams(Dana-Farber Cancer Institute), Chi-Yun Wu, Hao Wu, Hung‐Yi Wu, Matthew A. Wyczalkowski, Yubin Xie, Xiaolu Yang, Clarence Yapp, Wenbao Yu, Yinyin Yuan, Dadong Zhang, Kun Zhang, Mianlei Zhang, Nancy R. Zhang, Yantian Zhang, Yanyan Zhao, Daniel Cui Zhou, Zilu Zhou, Houxiang Zhu, Qin Zhu, Xiangzhu Zhu, Yuankun Zhu, Xiaowei Zhuang
Cited by 587Open Access
Abstract
Crucial transitions in cancer-including tumor initiation, local expansion, metastasis, and therapeutic resistance-involve complex interactions between cells within the dynamic tumor ecosystem. Transformative single-cell genomics technologies and spatial multiplex in situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution. The Human Tumor Atlas Network (HTAN), part of the National Cancer Institute (NCI) Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types. This effort complements both ongoing efforts to map healthy organs and previous large-scale cancer genomics approaches focused on bulk sequencing at a single point in time. Generating single-cell, multiparametric, longitudinal atlases and integrating them with clinical outcomes should help identify novel predictive biomarkers and features as well as therapeutically relevant cell types, cell states, and cellular interactions across transitions. The resulting tumor atlases should have a profound impact on our understanding of cancer biology and have the potential to improve cancer detection, prevention, and therapeutic discovery for better precision-medicine treatments of cancer patients and those at risk for cancer.