Exosomal miRNAs in tumor microenvironment

Shiming Tan(Central South University), Longzheng Xia(Central South University), Pin Yi(Central South University), Yaqian Han(Central South University), Lu Tang(Central South University), Qing Pan(Central South University), Yutong Tian(Central South University), Shan Rao(Central South University), Linda Oyang(Central South University), Jiaxin Liang(Central South University), Jinguan Lin(Central South University), Min Su(Central South University), Yingrui Shi(Central South University), Deliang Cao(Central South University), Yujuan Zhou(Central South University), Qianjin Liao(Central South University)
Journal of Experimental & Clinical Cancer Research
April 16, 2020
10.1186/s13046-020-01570-6
Cited by 216Open Access
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Abstract

Abstract Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as exosomes and cytokines. Exosomes are tiny extracellular vesicles (40-160nm) containing active substances, such as proteins, lipids and nucleic acids. Exosomes carry biologically active miRNAs to shuttle between tumor cells and TME, thereby affecting tumor development. Tumor-derived exosomal miRNAs induce matrix reprogramming in TME, creating a microenvironment that is conducive to tumor growth, metastasis, immune escape and chemotherapy resistance. In this review, we updated the role of exosomal miRNAs in the process of TME reshaping.

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