Transmission Potential of Asymptomatic and Paucisymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infections: A 3-Family Cluster Study in China

Xiaolin Jiang(Shandong Center for Disease Control and Prevention), Xiaoli Zhang, Xiang-Na Zhao(Chinese Center For Disease Control and Prevention), Cun-Bao Li, Jie Lei(Shandong Center for Disease Control and Prevention), Zengqiang Kou(Shandong Center for Disease Control and Prevention), Wenkui Sun(Shandong Center for Disease Control and Prevention), Hang Yang(Shandong Center for Disease Control and Prevention), Feng Gao(Linyi People's Hospital), Shengxiang Ji, Can-Fang Lin, Bo Pang(Shandong Center for Disease Control and Prevention), Mingxiao Yao(Shandong Center for Disease Control and Prevention), Benjamin D. Anderson(Duke Kunshan University), Guolin Wang(Institute of Microbiology), Yao Lin(Institute of Microbiology), Li‐Jun Duan(Institute of Microbiology), Dianmin Kang(Shandong Center for Disease Control and Prevention), Mai‐Juan Ma(Institute of Microbiology)
The Journal of Infectious Diseases
April 21, 2020
10.1093/infdis/jiaa206
Cited by 92Open Access
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Abstract

Data concerning the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in asymptomatic and paucisymptomatic patients are lacking. We report a 3-family cluster of infections involving asymptomatic and paucisymptomatic transmission. Eight of 15 (53%) members from 3 families were confirmed with SARS-CoV-2 infection. Of 8 patients, 3 were asymptomatic and 1 was paucisymptomatic. An asymptomatic mother transmitted the virus to her son, and a paucisymptomatic father transmitted the virus to his 3-month-old daughter. SARS-CoV-2 was detected in the environment of 1 household. The complete genomes of SARS-CoV-2 from the patients were > 99.9% identical and were clustered with other SARS-CoV-2 sequences reported from China and other countries.

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