Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes
Mayumi K. Holly(University of Washington), Xiao Han(University of British Columbia), Edward Zhao(University of Washington), Shauna M. Crowley(University of British Columbia), Joannie M. Allaire(University of British Columbia), Leigh A. Knodler(Washington State University), Bruce A. Vallance(University of British Columbia), Jason G. Smith(University of Washington)
Cited by 59Open Access
Abstract
Recent studies have determined that inflammasome signaling plays an important role in driving intestinal epithelial cell (IEC) responses to bacterial infections, such as Salmonella enterica serovar Typhimurium. There are two primary inflammasome pathways, canonical (involving caspase-1) and noncanonical (involving caspase-4 and -5 in humans and caspase-11 in mice). Prior studies identified the canonical inflammasome as the major pathway leading to interleukin-18 (IL-18) release and restriction of S .
Related Papers
No related papers found
Powered by citation graph analysis