Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2

Jianzhong Shi(Chinese Academy of Agricultural Sciences), Zhiyuan Wen(Chinese Academy of Agricultural Sciences), Gongxun Zhong(Chinese Academy of Agricultural Sciences), Huanliang Yang(Chinese Academy of Agricultural Sciences), Chong Wang(Chinese Academy of Agricultural Sciences), Baoying Huang(National Institute for Viral Disease Control and Prevention), Renqiang Liu(Chinese Academy of Agricultural Sciences), Xijun He(China Animal Disease Control Center), Lei Shuai(Chinese Academy of Agricultural Sciences), Ziruo Sun(Chinese Academy of Agricultural Sciences), Yubo Zhao(Chinese Academy of Agricultural Sciences), Peipei Liu(National Institute for Viral Disease Control and Prevention), Libin Liang(Chinese Academy of Agricultural Sciences), Pengfei Cui(Chinese Academy of Agricultural Sciences), Jinliang Wang(Chinese Academy of Agricultural Sciences), Xianfeng Zhang(China Animal Disease Control Center), Yuntao Guan(China Animal Disease Control Center), Wenjie Tan(National Institute for Viral Disease Control and Prevention), Guizhen Wu(National Institute for Viral Disease Control and Prevention), Hualan Chen(Chinese Academy of Agricultural Sciences), Zhigao Bu(China Animal Disease Control Center)
Science
April 8, 2020
10.1126/science.abb7015
Cited by 2,028Open Access
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Abstract

Alternative hosts and model animals The severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) pandemic may have originated in bats, but how it made its way into humans is unknown. Because of its zoonotic origins, SARS-CoV-2 is unlikely to exclusively infect humans, so it would be valuable to have an animal model for drug and vaccine development. Shi et al. tested ferrets, as well as livestock and companion animals of humans, for their susceptibility to SARS-CoV-2 (see the Perspective by Lakdawala and Menachery). The authors found that SARS-CoV-2 infects the upper respiratory tracts of ferrets but is poorly transmissible between individuals. In cats, the virus replicated in the nose and throat and caused inflammatory pathology deeper in the respiratory tract, and airborne transmission did occur between pairs of cats. Dogs appeared not to support viral replication well and had low susceptibility to the virus, and pigs, chickens, and ducks were not susceptible to SARS-CoV-2. Science , this issue p. 1016 ; see also p. 942

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