Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Xiaoguang Liu; Kellen Olszewski; Yilei Zhang; Esther W. Lim; Jiejun Shi; Xiaoshan Zhang; Jie Zhang; Hyemin Lee; Pranavi Koppula; Guang Lei; Zhuang Li; M. James You; Bingliang Fang; Wei Li; Christian M. Metallo; Masha V. Poyurovsky; Boyi Gan

doi:10.1038/s41556-020-0496-x

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Xiaoguang Liu(The University of Texas MD Anderson Cancer Center), Kellen Olszewski(Eon Corporation (United States)), Yilei Zhang(The University of Texas MD Anderson Cancer Center), Esther W. Lim(University of California San Diego), Jiejun Shi(Baylor College of Medicine), Xiaoshan Zhang(The University of Texas MD Anderson Cancer Center), Jie Zhang(The University of Texas MD Anderson Cancer Center), Hyemin Lee(The University of Texas MD Anderson Cancer Center), Pranavi Koppula(The University of Texas MD Anderson Cancer Center), Guang Lei(The University of Texas MD Anderson Cancer Center), Zhuang Li(The University of Texas MD Anderson Cancer Center), M. James You(The University of Texas MD Anderson Cancer Center), Bingliang Fang(The University of Texas MD Anderson Cancer Center), Wei Li(Baylor College of Medicine), Christian M. Metallo(University of California San Diego), Masha V. Poyurovsky(Eon Corporation (United States)), Boyi Gan(The University of Texas MD Anderson Cancer Center)

Nature Cell Biology

March 30, 2020

10.1038/s41556-020-0496-x

Cited by 589Open Access

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