Non-active antibiotic and bacteriophage synergism to successfully treat recurrent urinary tract infection caused by extensively drug-resistant <i>Klebsiella pneumoniae</i>
Juan Bao(Shanghai Public Health Clinical Center), Nannan Wu(Shanghai Public Health Clinical Center), Yigang Zeng(Shanghai Public Health Clinical Center), Liguang Chen(Shanghai Public Health Clinical Center), Linlin Li(Shanghai Institutes for Biological Sciences), Lan Yang(Shanghai Public Health Clinical Center), Yiyuan Zhang(Shanghai Public Health Clinical Center), Mingquan Guo(Shanghai Public Health Clinical Center), Lisha Li(Shanghai Jiao Tong University), Jie Li(Shanghai Public Health Clinical Center), Demeng Tan(Shanghai Public Health Clinical Center), Mengjun Cheng(Shanghai Public Health Clinical Center), Jingmin Gu(Shanghai Public Health Clinical Center), Jinghong Qin(Shanghai Jiao Tong University), Jiazhen Liu(Army Medical University), Shiru Li(Army Medical University), Guangqiang Pan(Army Medical University), Xin Jin(Shanghai Public Health Clinical Center), Bangxin Yao(Sun Yat-sen University), Xiaokui Guo(Shanghai Jiao Tong University), Tongyu Zhu(Sun Yat-sen University), Shuai Le(Army Medical University)
Cited by 175Open Access
Abstract
We report a case of a 63-year-old female patient who developed a recurrent urinary tract infection (UTI) with extensively drug-resistant Klebsiella pneumoniae (ERKp). In the initial two rounds of phage therapy, phage resistant mutants developed within days. Although ERKp strains were completely resistant to sulfamethoxazole-trimethoprim, the combination of sulfamethoxazole-trimethoprim with the phage cocktail inhibited the emergence of phage resistant mutant in vitro, and the UTI of patient was successfully cured by this combination. Thus, we propose that non-active antibiotic and bacteriophage synergism (NABS) might be an alternative strategy in personalized phage therapy.
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