Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses
Reza Nadafi(Leiden University Medical Center), Catarina Gago de Graça(Amsterdam University Medical Centers), Eelco D. Keuning(Amsterdam University Medical Centers), Jasper J. Koning(Amsterdam University Medical Centers), Sander de Kivit(Leiden University Medical Center), Tanja Konijn(Amsterdam University Medical Centers), Sandrine Henri(Centre National de la Recherche Scientifique), Jannie Borst(Leiden University Medical Center), Rogier M. Reijmers(Amsterdam University Medical Centers), Lisa G. M. van Baarsen(Amsterdam UMC Location University of Amsterdam), Reina E. Mebius(Amsterdam Neuroscience)
Cited by 72Open Access
Abstract
cells and germinal center B cell responses. Our findings uncover the ability of LNSCs to suppress the early activation of autoreactive immune cells and maintain peripheral tolerance.
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