Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics

Daniel Haensel(University of California, Irvine), Suoqin Jin(University of California, Irvine), Peng Sun(University of California, Irvine), Rachel Cinco(Fluor (United States)), Morgan Dragan(University of California, Irvine), Quy Nguyen(University of California, Irvine), Zixuan Cang(University of California, Irvine), Yanwen Gong(University of California, Irvine), Remy Vu(University of California, Irvine), Adam L. MacLean(University of California, Irvine), Kai Kessenbrock(University of California, Irvine), Enrico Gratton(Fluor (United States)), Qing Nie(University of California, Irvine), Xing Dai(University of California, Irvine)
Cell Reports
March 1, 2020
10.1016/j.celrep.2020.02.091
Cited by 245Open Access
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Abstract

state to early-response state, proliferate at the juncture of these two states, or become growth arrested before differentiating into spinous cells. Wound healing induces plasticity manifested by dynamic basal-spinous interconversions at multiple basal transcriptional states. Our study provides a systematic view of epidermal cellular dynamics, supporting a revised "hierarchical-lineage" model of homeostasis.

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