Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells
Shutoku Matsuyama(National Institute of Infectious Diseases), Naganori Nao(National Institute of Infectious Diseases), Kazuya Shirato(National Institute of Infectious Diseases), Miyuki Kawase(National Institute of Infectious Diseases), Shinji Saito(National Institute of Infectious Diseases), Ikuyo Takayama(National Institute of Infectious Diseases), Noriyo Nagata(National Institute of Infectious Diseases), Tsuyoshi Sekizuka(National Institute of Infectious Diseases), Hiroshi Katoh(National Institute of Infectious Diseases), Fumihiro Kato(National Institute of Infectious Diseases), Masafumi Sakata(National Institute of Infectious Diseases), Maino Tahara(National Institute of Infectious Diseases), Satoshi Kutsuna(National Center for Global Health and Medicine), Norio Ohmagari(National Center for Global Health and Medicine), Makoto Kuroda(National Institute of Infectious Diseases), Tadaki Suzuki(National Institute of Infectious Diseases), Tsutomu Kageyama(National Institute of Infectious Diseases), Makoto Takeda(National Institute of Infectious Diseases)
Cited by 1,629Open Access
Abstract
A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently spreading across many countries globally. Here, we show that a TMPRSS2-expressing VeroE6 cell line is highly susceptible to SARS-CoV-2 infection, making it useful for isolating and propagating SARS-CoV-2. Our results reveal that, in common with SARS- and Middle East respiratory syndrome-CoV, SARS-CoV-2 infection is enhanced by TMPRSS2.
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