SARS-CoV-2 Infection in Children

Xiaoxia Lü(Wuhan Children's Hospital), Liqiong Zhang(Wuhan Children's Hospital), Hui Du(Wuhan Children's Hospital), Jingjing Zhang(Huazhong University of Science and Technology), Yuan Y. Li(Huazhong University of Science and Technology), Jingyu Qu(Huazhong University of Science and Technology), Wenxin Zhang(Huazhong University of Science and Technology), Youjie Wang(Huazhong University of Science and Technology), Shuangshuang Bao(Huazhong University of Science and Technology), Ying Li(Huazhong University of Science and Technology), Chuansha Wu(Huazhong University of Science and Technology), Hongxiu Liu(Huazhong University of Science and Technology), Di Liu(Wuhan Institute of Virology), Jianbo Shao(Huazhong University of Science and Technology), Xuehua Peng(Huazhong University of Science and Technology), Yonghong Yang(Beijing Children’s Hospital), Zhisheng Liu(Wuhan Children's Hospital), Yun Xiang(Wuhan Children's Hospital), Furong Zhang(Wuhan Children's Hospital), Rona M. Silva(University of California, Davis), Kent E. Pinkerton(University of California, Davis), Kunling Shen(National Clinical Research Center for Digestive Diseases), Xiao Han(Association of Maternal and Child Health Programs), Shunqing Xu(Wuhan Children's Hospital), Gary Wong(Chinese University of Hong Kong)
New England Journal of Medicine
March 18, 2020
10.1056/nejmc2005073
Cited by 2,531Open Access
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Abstract

TO THE EDITOR:
\nAs of March 10, 2020, the 2019 novel coronavirus (SARS-CoV-2) has been responsible for more than 110,000 infections and 4000 deaths worldwide, but data regarding the epidemiologic characteristics and clinical features of infected children are limited.1-3 A recent review of 72,314 cases by the Chinese Center for Disease Control and Prevention showed that less than 1% of the cases were in children younger than 10 years of age.2 In order to determine the spectrum of disease in children, we evaluated children infected with SARS-CoV-2 and treated at the Wuhan Children’s Hospital, the only center assigned by the central government for treating infected children under 16 years of age in Wuhan. Both symptomatic and asymptomatic children with known contact with persons having confirmed or suspected SARS-CoV-2 infection were evaluated. Nasopharyngeal or throat swabs were obtained for detection of SARS-CoV-2 RNA by established methods.4 The clinical outcomes were monitored up to March 8, 2020.

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