A cell atlas of human thymic development defines T cell repertoire formation

Jong-Eun Park(Wellcome Sanger Institute), Rachel A. Botting(Newcastle University), Cecilia Domínguez Conde(Wellcome Sanger Institute), Dorin-Mirel Popescu(Newcastle University), Marieke Lavaert(Ghent University Hospital), Daniel J. Kunz(University of Cambridge), Issac Goh(Newcastle University), Emily Stephenson(Newcastle University), Roberta Ragazzini(Great Ormond Street Hospital), Elizabeth Tuck(Wellcome Sanger Institute), Anna Wilbrey-Clark(Wellcome Sanger Institute), Kenny Roberts(Wellcome Sanger Institute), Veronika R. Kedlian(Wellcome Sanger Institute), John R. Ferdinand(MRC Laboratory of Molecular Biology), Xiaoling He(University of Cambridge), Simone Webb(Newcastle University), Daniel Maunder(Newcastle University), Niels Vandamme(Ghent University), Krishnaa T. Mahbubani(University of Cambridge), Krzysztof Polański(Wellcome Sanger Institute), Lira Mamanova(Wellcome Sanger Institute), Liam Bolt(Wellcome Sanger Institute), David Crossland(Newcastle upon Tyne Hospitals NHS Foundation Trust), Fabrizio De Rita(Newcastle upon Tyne Hospitals NHS Foundation Trust), Andrew Fuller(Newcastle University), Andrew Filby(Newcastle University), Gary Reynolds(Newcastle University), David Dixon(Newcastle University), Kourosh Saeb‐Parsy(University of Cambridge), Steven Lisgo(Newcastle University), Deborah J. Henderson(Newcastle University), Roser Vento‐Tormo(Wellcome Sanger Institute), Omer Ali Bayraktar(Wellcome Sanger Institute), Roger A. Barker(Wellcome/MRC Cambridge Stem Cell Institute), Kerstin B. Meyer(Wellcome Sanger Institute), Yvan Saeys(Ghent University), Paola Bonfanti(Great Ormond Street Hospital), Sam Behjati(University of Cambridge), Menna R. Clatworthy(MRC Laboratory of Molecular Biology), Tom Taghon(Ghent University Hospital), Muzlifah Haniffa(Wellcome Sanger Institute), Sarah A. Teichmann(University of Cambridge)
Science
February 20, 2020
10.1126/science.aay3224
Cited by 714Open Access
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Abstract

Thymus development, cell by cell The human thymus is the organ responsible for the maturation of many types of T cells, which are immune cells that protect us from infection. However, it is not well known how these cells develop with a full immune complement that contains the necessary variation to protect us from a variety of pathogens. By performing single-cell RNA sequencing on more than 250,000 cells, Park et al. examined the changes that occur in the thymus over the course of a human life. They found that development occurs in a coordinated manner among immune cells and with their developmental microenvironment. These data allowed for the creation of models of how T cells with different specific immune functions develop in humans. Science , this issue p. eaay3224

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