Vascular endothelium–targeted <i>Sirt7</i> gene therapy rejuvenates blood vessels and extends life span in a Hutchinson-Gilford progeria model
Shimin Sun(Shandong University of Technology), Weifeng Qin(Shenzhen University Health Science Center), Xiaolong Tang(Shenzhen University Health Science Center), Yuan Meng(Shenzhen University Health Science Center), Wenjing Hu(Shenzhen University Health Science Center), Shuju Zhang(Shenzhen University Health Science Center), Minxian Qian(Shenzhen University Health Science Center), Zuojun Liu(Shenzhen University Health Science Center), Xinyue Cao(Shenzhen University Health Science Center), Qiuxiang Pang(Shandong University of Technology), Bosheng Zhao(Shandong University of Technology), Zimei Wang(Shenzhen University Health Science Center), Zhongjun Zhou(University of Hong Kong), Baohua Liu(Shenzhen University Health Science Center)
Cited by 103Open Access
Abstract
;TC mice. These data support endothelial dysfunction as a primary trigger of systemic aging and highlight gene therapy as a potential strategy for the clinical treatment of HGPS and age-related vascular dysfunction.
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