α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment
Linlin Zhang(German Center for Infection Research), Daizong Lin(Shanghai Institute of Materia Medica), Yuri Kusov(University of Lübeck), Yong Nian(Shanghai Institute of Materia Medica), Qingjun Ma(University of Lübeck), Jiang Wang(Shanghai Institute of Materia Medica), Albrecht von Brunn(Ludwig-Maximilians-Universität München), Pieter Leyssen(Rega Institute for Medical Research), Kristina Lanko(Rega Institute for Medical Research), Johan Neyts(Rega Institute for Medical Research), Adriaan de Wilde(Leiden University Medical Center), Eric J. Snijder(Leiden University Medical Center), Hong Liu(Shanghai Institute of Materia Medica), Rolf Hilgenfeld(Shanghai Institute of Materia Medica)
Cited by 606Open Access
Abstract
exhibits three-digit picomolar activity against the Middle East Respiratory Syndrome coronavirus.
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