Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
Isidro Cortés-Ciriano(European Bioinformatics Institute), Jake June-Koo Lee(Harvard University), Ruibin Xi(Peking University), Dhawal Jain(Harvard University), Youngsook L. Jung(Harvard University), Lixing Yang(University of Chicago), Dmitry A. Gordenin(National Institutes of Health), Leszek J. Klimczak(National Institutes of Health), Cheng‐Zhong Zhang(Broad Institute), David Pellman(Howard Hughes Medical Institute), PCAWG Structural Variation Working Group(The University of Texas MD Anderson Cancer Center), Kadir C. Akdemir(The University of Texas MD Anderson Cancer Center), Eva G. Álvarez(Universidade de Santiago de Compostela), Adrian Baez‐Ortega(Broad Institute), Rameen Beroukhim(Broad Institute), Paul C. Boutros(Ontario Institute for Cancer Research), David D.L. Bowtell(The University of Melbourne), Benedikt Brors(Johns Hopkins University), Kathleen H. Burns(Johns Hopkins University), Peter J. Campbell(University of Ottawa), Kin Chan(The University of Texas MD Anderson Cancer Center), Ken Chen(The University of Texas MD Anderson Cancer Center), Isidro Cortés-Ciriano(European Bioinformatics Institute), Ana Dueso-Barroso(Broad Institute), Andrew Dunford(Broad Institute), Paul A. Edwards(University of Cambridge), Xavier Estivill(Peter MacCallum Cancer Centre), Dariush Etemadmoghadam(The University of Melbourne), Lars Feuerbach(German Cancer Research Center), J. Lynn Fink(Bar-Ilan University), Milana Frenkel-Morgenstern(Bar-Ilan University), Dale W. Garsed(The University of Melbourne), Mark Gerstein(National Institutes of Health), Dmitry A. Gordenin(National Institutes of Health), David Haan(University of California, Santa Cruz), James E. Haber(Broad Institute), Julian M. Hess(Broad Institute), Barbara Hutter(German Cancer Research Center), Marcin Imieliński(German Cancer Research Center), David Jones(German Cancer Research Center), Young Seok Ju(Skolkovo Institute of Science and Technology), Marat D. Kazanov(Skolkovo Institute of Science and Technology), Leszek J. Klimczak(National Institutes of Health), Youngil Koh(European Bioinformatics Institute), Jan O. Korbel(Broad Institute), Kiran Kumar(Broad Institute), Eunjung Alice Lee(Boston Children's Hospital), Jake June-Koo Lee(Harvard University), Yilong Li(University of Cambridge), Andy G. Lynch(University of St Andrews), Geoff Macintyre(University of Cambridge), Florian Markowetz(University of Cambridge), Iñigo Martincorena(Cornell University), Alexander Martinez‐Fundichely(Cornell University), Satoru Miyano(Dana-Farber Cancer Institute), Hidewaki Nakagawa(Yale University), Fabio C. P. Navarro(Yale University), Stephan Ossowski(Harvard University), Peter J. Park(Harvard University), John V. Pearson(Universitat Pompeu Fabra), Montserrat Puiggròs(The University of Queensland), Karsten Rippe(The University of Queensland), Nicola D. Roberts(German Cancer Research Center), Steven A. Roberts(German Cancer Research Center), Bernardo Rodriguez-Martin(Universidade de Santiago de Compostela), Steven E. Schumacher(Broad Institute), Ralph Scully(Rigshospitalet), Mark Shackleton(Beth Israel Deaconess Medical Center), Nikos Sidiropoulos(Beth Israel Deaconess Medical Center), Lina Sieverling(Broad Institute), Chip Stewart(Broad Institute), David Torrents(Universidade de Santiago de Compostela), José M. C. Tubío(Universidade de Santiago de Compostela), Izar Villasante(German Cancer Research Center), Nicola Waddell(Institució Catalana de Recerca i Estudis Avançats), Jeremiah A. Wala(Broad Institute), Joachim Weischenfeldt(Beth Israel Deaconess Medical Center), Lixing Yang(University of Chicago), Xiaotong Yao(Cornell University), Sung-Soo Yoon(Universidade de Santiago de Compostela), Jorge Zamora(Universidade de Santiago de Compostela), Cheng-Zhong Zhang(Broad Institute), Peter J. Park(Harvard University), Lauri A. Aaltonen, Federico Abascal(The University of Melbourne), Adam Abeshouse, Hiroyuki Aburatani, David J. Adams, Nishant Agrawal, Keun Soo Ahn, Sung‐Min Ahn, Hiroshi Aikata, Rehan Akbani(The University of Texas MD Anderson Cancer Center), Kadir C. Akdemir(The University of Texas MD Anderson Cancer Center), Hikmat Al‐Ahmadie, Sultan T. Al‐Sedairy, Fátima Al‐Shahrour, Malik Alawi, Monique Albert, Kenneth Aldape, Ludmil B. Alexandrov(University of Cambridge), Adrian Ally, Kathryn Alsop(Universidade de Santiago de Compostela), Eva G. Álvarez(Universidade de Santiago de Compostela), Fernanda Amary, Samirkumar B. Amin, Brice Aminou(Harvard University), Ole Ammerpohl, Matthew J. Anderson(Dana-Farber Cancer Institute), Yeng Ang, Davide Antonello, Pavana Anur, Samuel Aparício, Elizabeth L. Appelbaum, Yasuhito Arai, Axel Aretz, Koji Arihiro, Shun‐ichi Ariizumi, Joshua Armenia, Laurent Arnould(Barcelona Supercomputing Center), L. Sylvia, Yassen Assenov, Gurnit Atwal, Sietse Aukema, J. Todd Auman, Miriam R. R. Aure, Philip Awadalla, Marta Aymerich, Gary D. Bader(University of Cambridge), Adrian Baez‐Ortega(University of Cambridge), Matthew H. Bailey(University of Cambridge), Peter J. Bailey, Miruna Balasundaram, Saianand Balu, Pratiti Bandopadhayay, Rosamonde E. Banks, Stefano Barbi, Andrew P. Barbour, Jonathan Barenboim, Jill S. Barnholtz‐Sloan(Barcelona Supercomputing Center), Hugh Barr, Elisabet Barrera(Universitat Pompeu Fabra), John G. Bartlett, Javier Bartolomé, Claudio Bassi, Oliver F. Bathe, Daniel Baumhoer, Prashant Bavi, Stephen B. Baylin, Wojciech Bażant, Duncan Beardsmore, Tim Beck, Sam Behjati, Andreas Behren, Beifang Niu(University of Cambridge), Cindy Bell, Sergi Beltrán, Christopher C. Benz(Broad Institute), Andrew Berchuck, Anke K. Bergmann, Erik N. Bergstrom, Benjamin P. Berman, Daniel M. Berney, Stephan H. Bernhart(Broad Institute), Rameen Beroukhim(Broad Institute), Mario Berríos, Samantha Bersani, Johanna Bertl, Miguel Betancourt, Vinayak Bhandari, Shriram G. Bhosle, Andrew V. Biankin, Matthias Bieg, Darell D. Bigner, Hans Binder, Ewan Birney, Michael J. Birrer, Nidhan K. Biswas, Bodil Bjerkehagen, Tom Bodenheimer(University of Cambridge), Lori Boice, Giada Bonizzato, Johann S. de Bono, Arnoud Boot, Moiz S. Bootwalla(Harvard University), Åke Borg, Arndt Borkhardt, Keith A. Boroevich, Ivan Borozan, Christoph W. Borst, Marcus Bosenberg, Mattia Bosio, Jacqueline Boultwood, Guillaume Bourque(Ontario Institute for Cancer Research), Paul C. Boutros(Ontario Institute for Cancer Research), G. Steven Bova(Heidelberg University), David Bowen, Reanne Bowlby(The University of Melbourne), David D.L. Bowtell(The University of Melbourne), Sandrine Boyault, Rich Boyce, Jeffrey M. Boyd, Alvis Brāzma(University of Cambridge), Paul M. Brennan, Daniel S. Brewer, Arie B. Brinkman, Robert G. Bristow, Russell R. Broaddus, Jane E. Brock, Malcolm V. Brock, Annegien Broeks, Angela N. Brooks, Denise Brooks(National Center for Tumor Diseases), Benedikt Brors(German Cancer Research Center), Søren Brunak, Timothy J. C. Bruxner, Alicia L. Bruzos(Cornell University), Alex Buchanan, Ivo Buchhalter, Christiane Buchholz, Susan Bullman, Hazel Burke, Birgit Burkhardt(Johns Hopkins University), Kathleen H. Burns(Johns Hopkins University), John Busanovich, Carlos D. Bustamante, Adam P. Butler, Atul J. Butte, Niall J. Byrne, Anne‐Lise Børresen‐Dale, Rory Johnson(University of St Andrews), Andy Cafferkey, Declan Cahill, Claudia Calabrese, Carlos Caldas, Fabien Calvo, Niedzica Camacho(University of Cambridge), Peter J. Campbell(University of Cambridge), Elı́as Campo, Cinzia Cantù, Shaolong Cao, Thomas E. Carey, Joana Carlevaro-Fita, Rebecca Carlsen, Ivana Cataldo, Mario Cazzola, Jonathan Cebon(German Cancer Research Center), Robert J. Cerfolio, Dianne Chadwick, Dimple Chakravarty, Drc Chalmers(University of Ottawa), Calvin Wing Yiu Chan(University of Ottawa), Kin Chan(University of Ottawa), Michelle Chan‐Seng‐Yue, Vishal S. Chandan, David K. Chang, Stephen J. Chanock, Lorraine A. Chantrill, Aurélien Chateigner, Nilanjan Chatterjee, Kazuaki Chayama(Charité - Universitätsmedizin Berlin), Hsiao-Wei Chen(Charité - Universitätsmedizin Berlin), Jieming Chen(The University of Texas MD Anderson Cancer Center), Ken Chen(The University of Texas MD Anderson Cancer Center), Yiwen Chen(Charité - Universitätsmedizin Berlin), Zhaohong Chen, Andrew D. Cherniack, Jeremy Chien, Yoke-Eng Chiew, Suet‐Feung Chin, Juok Cho, Sunghoon Cho, Jung Kyoon Choi, Wan Choi, Christine Chomienne, Zechen Chong, Su Pin Choo, Angela Chou, Angelika N. Christ, Elizabeth L. Christie, Eric Chuah, Carrie Cibulskis, Kristian Cibulskis, Sara Cingarlini(University of Cambridge), Peter Clapham(Cornell University), Alexander Claviez, Sean P. Cleary, Nicole Cloonan, Marek Cmero, Colin C. Collins, Ashton A. Connor, Susanna L. Cooke, Colin S. Cooper, Leslie Cope, Vincenzo Corbo, Matthew G. Cordes, Stephen Cordner(University of Cambridge), Isidro Cortés‐Ciriano(European Bioinformatics Institute), Kyle R. Covington, Prue A. Cowin, Brian Craft(Heidelberg University), David Craft, Chad J. Creighton, Yupeng Cun, Erin Curley, Ioana Cutcutache, Karolina Czajka, Bogdan Czerniak, Rebecca A. Dagg, Ludmila Danilova(Heidelberg University), Maria Vittoria Davì, Natalie R. Davidson, Helen Davies, Ian J. Davis, Brandi N. Davis‐Dusenbery, Kevin J. Dawson, Francisco M. De La Vega, Ricardo De Paoli‐Iseppi, Timothy Defreitas, Angelo Paolo Dei Tos, Olivier Delaneau(Universitat Pompeu Fabra), John A. Demchok, Jonas Demeulemeester, German Demidov, Deniz Demircioğlu, Nening M. Dennis, Robert E. Denroche, Stefan C. Dentro, Nikita Desai, Vikram Deshpande, Amit G. Deshwar, Christine Desmedt, Jordi Deu-Pons, Noreen Dhalla, Neesha C. Dhani, Priyanka Dhingra, Rajiv Dhir, Anthony DiBiase, Klev Diamanti(University of Copenhagen), Li Ding, Shuai Ding, Huy Q. Dinh, Luc Dirix, HarshaVardhan Doddapaneni, Nilgun Donmez, Michelle T. Dow, Ronny Drapkin, Oliver Drechsel, Ruben M. Drews, Serge Serge, Tim Dudderidge(Barcelona Supercomputing Center), Ana Dueso-Barroso(Broad Institute), Andrew Dunford(Broad Institute), Michael J. Dünn, Lewis Jonathan Dursi, Fraser R. Duthie(The University of Texas MD Anderson Cancer Center), Ken Dutton‐Regester, Jenna Eagles, Douglas F. Easton, Stuart Edmonds(University of Cambridge), Paul A. Edwards(University of Cambridge), Sandra E. Edwards, Rosalind A. Eeles, Anna Ehinger, Juergen Eils, Roland Eils, Adel K. El‐Naggar, Matthew Eldridge, Kyle Ellrott, Serap Erkek, Geòrgia Escaramís, Shadrielle M. G. Espiritu, Xavier Estivill(The University of Melbourne), Dariush Etemadmoghadam(The University of Melbourne), Jorunn E. Eyfjord, Bishoy M. Faltas, Daiming Fan, Yu Fan, William C. Faquin, Claudiu Farcas, Matteo Fassan, Aquila Fatima, Francesco Favero, Nodirjon Fayzullaev(University of Copenhagen), Ina Felau, Sián Fereday, Martin L. Ferguson, Vincent Ferretti(German Cancer Research Center), Lars Feuerbach(German Cancer Research Center), Matthew A. Field(The University of Queensland), J. Lynn Fink(The University of Queensland), Gaetano Finocchiaro, Cyril Fisher, Matthew W. Fittall, Anna Fitzgerald, Rebecca C. Fitzgerald, Adrienne M. Flanagan, Neil Fleshner(University of Cambridge), Paul Flicek(Universitat Pompeu Fabra), John A. Foekens, Kwun M. Fong, Nuno A. Fonseca, Christopher S. Foster, Natalie S. Fox, Michael Fraser, Scott Frazer(Bar-Ilan University), Milana Frenkel-Morgenstern(Bar-Ilan University), William A. Friedman, Joan Frigola, Catrina C. Fronick, Akihiro Fujimoto, Masashi Fujita, Masashi Fukayama, Lucinda A. Fulton(German Cancer Research Center), Robert S. Fulton, Mayuko Furuta, P. Andrew Futreal, Anja Füllgrabe, Stacey Gabriel(Washington State University), Steven Gallinger, Carlo Gambacorti‐Passerini, Jianjiong Gao, Shengjie Gao, Levi A. Garraway, Øystein Garred, Erik Garrison(The University of Melbourne), Dale W. Garsed(The University of Melbourne), Nils Gehlenborg, Josep L. L. Gelpi, Joshy George, Daniela S. Gerhard, Clarissa Gerhäuser, Jeffrey E. Gershenwald(Yale University), Mark Gerstein(Princeton University), Moritz Gerstung, Gad Getz, Mohammed Ghori, Ronald Ghossein, Nasra H. Giama, Richard A. Gibbs, Bob Gibson, Anthony J. Gill, Pelvender Gill, Dilip D. Giri, Dominik Głodzik, Vincent J. Gnanapragasam, Maria Elisabeth Goebler, Mary J. Goldman, Carmen Gómez, Santiago Gonzalez, Abel González-Pérez(National Institutes of Health), Dmitry A. Gordenin(National Institutes of Health), James Gossage, Kunihito Gotoh, Ramaswamy Govindan, Dorthe Grabau, Janet S. Graham, Robert C. Grant, Anthony R. Green, Eric Green, Liliana Greger(German Cancer Research Center), Nicola Grehan, Sonia Grimaldi, Sean M. Grimmond, Robert L. Grossman(The University of Melbourne), Adam Grundhoff, Gunes Gundem, Qianyun Guo, Manaswi Gupta, Shailja Gupta, Marta Gut, Marta Gut, Jonathan Göke(Rigshospitalet), Gavin Ha, Andrea Haake(University of California, Santa Cruz), David Haan(University of California, Santa Cruz), Siegfried Haas, Kerstin Haase(Brandeis University), James E. Haber(Brandeis University), Nina Habermann, Faraz Hach, Syed Haider, Natsuko Hama, Freddie C. Hamdy, Anne Hamilton, Mark P. Hamilton(Centre for Genomic Regulation), Leng Han, George B. Hanna(Cornell University), Martin Hansmann, Nicholas J. Haradhvala, Olivier Harismendy, Ivon Harliwong, Arif Harmanci, Eoghan Harrington, Takanori Hasegawa(Heidelberg University), David Haussler(Washington State University), Steve Hawkins, Shinya Hayami, Shuto Hayashi, D. Neil Hayes, Stephen J. Hayes, Nicholas K. Hayward(Washington State University), Steven Hazell(Charité - Universitätsmedizin Berlin), Yao He, Allison P. Heath, Simon Heath(Heidelberg University), David W. Hedley, Apurva M. Hegde, David I. Heiman, Michael C. Heinold, Zachary Heins, Lawrence E. Heisler(Universidade de Santiago de Compostela), Eva Hellström‐Lindberg, Mohamed Helmy, Seong Gu Heo, Austin J. Hepperla, José María Heredia‐Genestar, Carl Herrmann(University of Cambridge), Peter Hersey(Massachusetts General Hospital), Julian M. Hess(Broad Institute), Hólmfríður Hilmarsdóttir, Jonathan Hinton, Satoshi Hirano, Nobuyoshi Hiraoka, Katherine A. Hoadley, Asger Hobolth, Ermin Hodzic, Jessica I. Hoell(Washington State University), Steve Hoffmann, Oliver Hofmann, Andrea Holbrook, Aliaksei Z. Holik, Michael A. Hollingsworth, Oliver Wendell Holmes(German Cancer Research Center), Robert A. Holt(Dana-Farber Cancer Institute), Chen Hong(Dana-Farber Cancer Institute), Eun Pyo Hong(Dana-Farber Cancer Institute), Jongwhi H. Hong, Gerrit K. Hooijer, Henrik Hornshøj, Fumie Hosoda, Yong Hou, Volker Hovestadt, William Howat, Alan P. Hoyle, Ralph H. Hruban(Washington State University), Taobo Hu(Washington State University), Taobo Hu(University of Chicago), Xing Hua, Kuan‐lin Huang, Mei Huang, Mi Ni Huang, Vincent Huang(Wellcome Sanger Institute), Yi Huang, Wolfgang Huber, Thomas J. Hudson, Michael Hummel, Jillian A. Hung(Heidelberg University), David G. Huntsman, Ted R. Hupp, Jason T. Huse, Matthew R. Huska(German Cancer Research Center), Barbara Hutter(German Cancer Research Center), Carolyn M. Hutter, Daniel Hübschmann, Christine A. Iacobuzio–Donahue, Charles D. Imbusch(Cornell University), Marcin Imieliński(Cornell University), Seiya Imoto, William B. Isaacs, Keren Isaev, Shumpei Ishikawa, Murat Iskar, S. M. Ashiqul Islam, Michael Ittmann, Sinisa Ivkovic, José M. G. Izarzugaza, Jocelyne Jacquemier, Valerie Jakrot, Nigel B. Jamieson, Gun Ho Jang, Se Jin Jang, Joy C. Jayaseelan, Reyka G. Jayasinghe, Stuart R. Jefferys, Karine Jegalian, Jennifer L. Jennings, Seung-Hyup Jeon, Lara Jerman, Yuan Ji(Charité - Universitätsmedizin Berlin), Wei Jiao(University of Cambridge), Peter A. Johansson, Amber L. Johns, Jeremy Johns, Rory Johnson, Todd A. Johnson, Clemency Jolly, Yann Joly, Jón G. Jónasson(German Cancer Research Center), Corbin D. Jones(German Cancer Research Center), David R. Jones(German Cancer Research Center), David Jones(German Cancer Research Center), Nic Jones(German Cancer Research Center), Steven J.M. Jones(Universidade de Santiago de Compostela), Jos Jonkers(Korea Advanced Institute of Science and Technology), Young Seok Ju(Korea Advanced Institute of Science and Technology), Hartmut Juhl(Boston Children's Hospital), Jongsun Jung, Malene Juul, Randi Istrup Juul, Randi Istrup Juul, Natalie Jäger, Rolf Kabbe(Broad Institute), André Kahles, Abdullah Kahraman, Vera B. Kaiser, Hojabr Kakavand, Sangeetha Kalimuthu, Christof von Kalle, Koo Jeong Kang, Katalin Karászi, Beth Y. Karlan, Rosa Karlić, Dennis Karsch, Katayoon Kasaian, Karin S. Kassahn, Hitoshi Katai, Mamoru Kato, Hiroto Katoh, Yoshiiku Kawakami, Jonathan D. Kay, Stephen H. Kazakoff(Skolkovo Institute of Science and Technology), Marat D. Kazanov(Skolkovo Institute of Science and Technology), Maria Keays, Electron Kebebew, Richard Kefford, Manolis Kellis(The University of Texas MD Anderson Cancer Center), James G. Kench, Catherine J. Kennedy, Jules N. A. Kerssemakers(Heidelberg University), David Khoo, Vincent Khoo, Narong Khuntikeo, Ekta Khurana, Helena Kilpinen, Hark Kyun Kim, Hyung‐Lae Kim, Hyung-Yong Kim, Hyunghwan Kim, Jaegil Kim, Ji Hoon Kim, Jong K. Kim, Young-Wook Kim, Tari A. King, Wolfgang Hiddemann, Kortine Kleinheinz(National Institutes of Health), Leszek J. Klimczak(National Institutes of Health), Stian Knappskog, Michael Kneba, Bartha Maria Knoppers(Seoul National University Hospital), Youngil Koh(Seoul National University Hospital), Jan Komorowski, Daisuke Komura, Mitsuhiro Komura(Universidade de Santiago de Compostela), Gu Kong(Harvard University), Marcel Kool(European Molecular Biology Laboratory), Jan O. Korbel(European Bioinformatics Institute), Viktoriya Korchina, Andrey Korshunov, Michael Koscher, Roelof Koster, Zsofia Kote‐Jarai, Antonios Koures, Milena Kovacevic(German Cancer Research Center), Bárbara Kremeyer, Helene Kretzmer, Markus Kreuz, Savitri Krishnamurthy, Dieter Kube(Broad Institute), Kiran Kumar(Broad Institute), Pardeep Kumar(Broad Institute), Sushant Kumar(Broad Institute), Yogesh Kumar, Ritika Kundra, Kirsten Kübler, Ralf Küppers, Jesper Lagergren, Phillip H. Lai, Peter W. Laird, Sunil R. Lakhani, Christopher M. Lalansingh, Emilie Lalonde, Fabien C. Lamaze(The University of Melbourne), Adam Lambert, Eric Lander, Pablo Landgraf, Luca Landoni, Anita Langerød, Andrés Lanzós, Denis Larsimont, Erik Larsson(Rigshospitalet), Mark Lathrop, Loretta M. S. Lau, Chris Lawerenz, Rita T. Lawlor, Michael S. Lawrence, Alexander J. Lazar, Ana Mijalkovic Lazic(Rigshospitalet), Xuan Le(Boston Children's Hospital), Darlene Lee(Boston Children's Hospital), Dong-Hoon Lee(Boston Children's Hospital), Eunjung Alice Lee(Boston Children's Hospital), Hee Jin Lee(Harvard University), Jake June-Koo Lee(Boston Children's Hospital), Jeong‐Yeon Lee(Boston Children's Hospital), Ju‐Hee Lee(Boston Children's Hospital), Ming Ta Michael Lee, Henry Lee-Six, Kjong-Van Lehmann, Hans Lehrach, Dido Lenze, Conrad Leonard, Daniel Leongamornlert, Ignaty Leshchiner, Louis Létourneau, Ivica Letunić, Douglas A. Levine, Lora Lewis, Tim Ley(University of Copenhagen), Chang Li(University of Copenhagen), Constance H. Li(University of Copenhagen), Haiyan Irene Li(Boston Children's Hospital), Jun Li(University of Copenhagen), Lin Li(University of Copenhagen), Shantao Li(University of Copenhagen), Siliang Li(University of Copenhagen), Xiaobo Li(University of Copenhagen), Xiaotong Li(University of Copenhagen), Xinyue Li(Wellcome Sanger Institute), Yilong Li(Wellcome Sanger Institute), Han Liang, Sheng‐Ben Liang(University of Cambridge), Péter Lichter(University of Copenhagen), Pei Lin(University of Copenhagen), Ziao Lin, W. Marston Linehan, Ole Christian Lingjærde, Dongbing Liu, Eric Minwei Liu, Fei-Fei Fei Liu, Fenglin Liu, Jia Liu, Xingmin Liu, Julie Livingstone, Dimitri Livitz, Naomi Livni, Lucas Lochovsky, Markus Loeffler(Wellcome Sanger Institute), Georgina V. Long, Armando López‐Guillermo, Shaoke Lou, David N. Louis, Laurence Lovat, Yiling Lu, Yong‐Jie Lu, Youyong Lu, Claudio Luchini, Ilinca M. Lungu, Xuemei Luo, Hayley J. Luxton(University of St Andrews), Andy G. Lynch(University of St Andrews), Lisa Lype, C. López, Carlos López-Otı́n(Rigshospitalet), Z. Eric(Rigshospitalet), Yussanne Ma, Gaëtan MacGrogan, Shona MacRae(University of Cambridge), Geoff Macintyre(University of Cambridge), Tobias Madsen, Kazuhiro Maejima, Andrea Mafficini, Dennis T. Maglinte, Arindam Maitra, Partha P. Majumder, Luca Malcovati, Salem Malikić, Giuseppe Malleo, Graham J. Mann, Luisa Mantovani‐Löffler(Johns Hopkins University), Kathleen Marchal, Giovanni Marchegiani, Elaine R. Mardis(The University of Melbourne), Adam A. Margolin, Maximillian G. Marin(University of Cambridge), Florian Markowetz(University of Cambridge), Julia Markowski(Rigshospitalet), Jeffrey R. Marks, Tomàs Marquès‐Bonet, Marco A. Marra, Luke Marsden, John W.M. Martens(Cornell University), Sancha Martin, José I. Martín‐Subero(Wellcome Sanger Institute), Iñigo Martincorena(Cornell University), Alexander Martinez‐Fundichely(Cornell University), Yosef E. Maruvka, R. Jay Mashl, Charlie E. Massie, Thomas J. Matthew, Lucy Matthews, Erik Mayer, Simon Mayes, Michael Mayo, Faridah Mbabaali, Karen McCune, Ultan McDermott, Patrick D. McGillivray, Michael D. McLellan, John D. McPherson, John R. McPherson, Treasa A. McPherson, Samuel R. Meier(Boston Children's Hospital), Alice Meng, Shaowu Meng(Broad Institute), Andrew Menzies, Neil D. Merrett, Sue Merson, Matthew Meyerson, William Meyerson, Piotr A. Mieczkowski, George L. Mihaiescu, Sanja Mijalković, Tom Mikkelsen, Michele Stanislaw Milella, Linda Mileshkin, Christopher A. Miller, David K. Miller, Jessica K. Miller, Gordon B. Mills(Bar-Ilan University), Ana Milovanovic, Sarah Minner, Marco Miotto, Gisela Mir Arnau, Lisa Mirabello, Thomas J. Mitchell, Thomas J. Mitchell(Dana-Farber Cancer Institute), Satoru Miyano(Dana-Farber Cancer Institute), Naoki Miyoshi, Shinichi Mizuno, Fruzsina Molnár-Gábor, Malcolm J. Moore, Richard A. Moore, Sandro Morganella, Quaid Morris, Quaid Morris, Lisle E. Mose, Catherine D. Moser, Ferran Muiños, Loris Mularoni(Broad Institute), Andrew J. Mungall, Karen Mungall, Elizabeth A. Musgrove, Ville Mustonen(Heidelberg University), David G. Mutch, Francesc Muyas, Donna M. Muzny, Alfonso Muñoz, Jerome K. Myers(German Cancer Research Center), Ola Myklebost(University of Cambridge), Peter Möller, Genta Nagae, Adnan Nagrial, Hardeep K. Nahal-Bose, Hitoshi Nakagama(The University of Tokyo), Hidewaki Nakagawa(The University of Tokyo), Hiromi Nakamura(Dana-Farber Cancer Institute), Tõru Nakamura, Kaoru Nakano, Tannistha Nandi, Jyoti Nangalia(Institució Catalana de Recerca i Estudis Avançats), Mia Nastic(Yale University), Arcadi Navarro(Yale University), Fabio C. P. Navarro(Yale University), David E. Neal, Gerd Nettekoven, Felicity Newell, Steven Newhouse, Yulia Newton(Cornell University), Alvin Wei Tian Ng(Cornell University), Chi‐Fai Ng, Jonathan Nicholson(German Cancer Research Center), David A. Nicol, Yongzhan Nie, G. Petur Nielsen, Morten Muhlig Nielsen, Serena Nik‐Zainal, Michael S. Noble, Kátia Nones(University of Cambridge), Paul A. Northcott, Faiyaz Notta, Brian D. O’Connor(University of Cambridge), Peter O’Donnell, Maria O’Donovan, Sarah O’Meara, Brian Patrick O’Neill, J. Robert O’Neill(Heidelberg University), David Ocaña, Angelica Ochoa, Layla Oesper, Christopher Ogden, Hideki Ohdan, Kazuhiro Ohi, Lucila Ohno‐Machado, Karin A. Oien, Akinyemi I. Ojesina, Hidenori Ojima, Takuji Okusaka, Larsson Omberg(Cornell University), Choon Kiat Ong(Centre for Genomic Regulation), Stephan Ossowski(Centre for Genomic Regulation), German Ott, B. F. Francis Ouellette, Christine P’ng, Marta Paczkowska, Salvatore Paiella, Chawalit Pairojkul, Marina Pajic, Qiang Pan‐Hammarström, Elli Papaemmanuil, Irene Papatheodorou, Nagarajan Paramasivam(Harvard University), Ji Wan Park(Harvard University), Joong‐Won Park(Harvard University), Keunchil Park(Harvard University), Kiejung Park(Harvard University), Peter J. Park(Harvard University), Peter J. Park, Simon L. Parsons, Harvey I. Pass, Danielle Pasternack, Alessandro Pastore, Ann‐Marie Patch, Iris Pauporté(Universitat Pompeu Fabra), Antonio Pea(Universitat Pompeu Fabra), John V. Pearson(Universitat Pompeu Fabra), Chandra Sekhar Pedamallu, Jakob Skou Pedersen, Paolo Pederzoli(Cornell University), Martin Peifer, Nathan A. Pennell, Charles M. Perou, Marc D. Perry, Gloria M. Petersen, Myron Peto, Nicholas J. Petrelli(German Cancer Research Center), Robert Petryszak, Stefan M. Pfister(Rigshospitalet), Mark Phillips, Oriol Pich, Hilda A. Pickett, Todd Pihl, Nischalan Pillay, Sarah E. Pinder(Rigshospitalet), Mark Pinese, Andreia V. Pinho, Esa Pitkänen, Xavier Pivot, Elena Piñeiro-Yáñez, Laura Planko, Christoph Plass, Paz Polak, Tirso Pons, Irinel Popescu, Olga Potapova, Aparna Prasad, Shaun R. Preston, Manuel Prinz, Antonia L. Pritchard, Stephenie D. Prokopec, Elena Provenzano, Xosé S. Puente(Barcelona Supercomputing Center), Sonia Puig(Barcelona Supercomputing Center), Montserrat Puiggròs(Barcelona Supercomputing Center), Sergio Pulido-Tamayo, Gulietta M. Pupo, Colin A. Purdie, Michael C. Quinn, Raquel Rabionet, Janet S. Rader, Bernhard Radlwimmer, Petar Radovic, Benjamin Raeder, Keiran Raine, Manasa Ramakrishna, Kamna Ramakrishnan, Suresh Ramalingam, Benjamin J. Raphael, W. Kimryn Rathmell, Tobias Rausch, Guido Reifenberger, Jüri Reimand(Universidade de Santiago de Compostela), Jorge S. Reis‐Filho, Victor E. Reuter, Iker Reyes-Salazar, Matthew A. Reyna, Sheila M. Reynolds, Esther Rheinbay, Yasser Riazalhosseini, Andrea L. Richardson(Massachusetts General Hospital), Julia Richter, Matthew D. Ringel, Markus Ringnér, Yasushi Rino(The University of Queensland), Karsten Rippe(The University of Queensland), Jeffrey Roach(German Cancer Research Center), Lewis R. Roberts(Wellcome Sanger Institute), Nicola D. Roberts(German Cancer Research Center), Steven A. Roberts(German Cancer Research Center), A. Gordon Robertson, Alan J. Robertson(Universidade de Santiago de Compostela), Javier Bartolomé Rodriguez(Universidade de Santiago de Compostela), Bernardo Rodriguez-Martin(Universidade de Santiago de Compostela), F. Germán Rodríguez-González, Michael H. A. Roehrl, Marius Rohde, Hirofumi Rokutan, Gilles Romieu, Ilse Rooman, Tom Roques, Daniel Rosebrock(Skolkovo Institute of Science and Technology), Mara Rosenberg, Philip Rosenstiel, Andreas Rosenwald, Edward Rowe, Romina Royo, Steve Rozen, Yulia Rubanova(Rigshospitalet), Mark A. Rubin, Carlota Rubio-Pérez, Vasilisa A. Rudneva, Borislav C. Rusev, Andrea Ruzzenente, Gunnar Rätsch, Radhakrishnan Sabarinathan, Veronica Y. Sabelnykova, Sara Sadeghi, S. Cenk Sahinalp, Natalie Saini, Mihoko Saito-Adachi, Gordon Saksena, Adriana Salcedo, Roberto Salgado, Leonidas Salichos, Richard Sallari, Charles Saller, Roberto Salvia, Michelle Sam, Jaswinder S. Samra, Francisco Sánchez-Vega, Chris Sander, Grant Sanders, Rajiv Sarin, Iman Sarrafi, Aya Sasaki-Oku, Torill Sauer, Guido Sauter, Robyn P.M. Saw, Maria Scardoni, Christopher J. Scarlett, Aldo Scarpa, Ghislaine Scélo, Dirk Schadendorf, Jacqueline E. Schein, Markus B. Schilhabel, Matthias Schlesner, Thorsten Schlomm, Heather K. Schmidt, Sarah‐Jane Schramm, Stefan Schreiber, Nikolaus Schultz(Washington State University), Steven E. Schumacher(Broad Institute), Roland F. Schwarz, Richard A. Scolyer(Heidelberg University), David W. Scott(Dana-Farber Cancer Institute), Ralph Scully(Dana-Farber Cancer Institute), Raja R. Seethala, Ayellet V. Segrè, Iris Selander, Colin A. Semple, Yasin Şenbabaoğlu, Subhajit Sengupta, Elisabetta Sereni(Barcelona Supercomputing Center), Stefano Serra, Dennis C. Sgroi(Rigshospitalet), Mark Shackleton(The University of Melbourne), Nimish Shah, Sagedeh Shahabi, Catherine A. Shang, Ping Shang, Ofer Shapira, Troy Shelton, Ciyue Shen, Hui Shen, Rebecca Shepherd, Ruian Shi(Dana-Farber Cancer Institute), Yan Shi, Yu-Jia Shiah, Tatsuhiro Shibata, Juliann Shih, Eigo Shimizu, Kiyo Shimizu, Seung Jun Shin, Yuichi Shiraishi, Tal Shmaya, Ilya Shmulevich, Solomon I. Shorser, Charles Short, Raunak Shrestha, Suyash Shringarpure, Craig D. Shriver, Shimin Shuai(Beth Israel Deaconess Medical Center), Nikos Sidiropoulos(Beth Israel Deaconess Medical Center), Reiner Siebert, Anieta M. Sieuwerts(University of Copenhagen), Lina Sieverling(University of Copenhagen), Sabina Signoretti, Katarzyna Sikora, Michele Simbolo, Ronald Simon, Janae V. Simons, Jared T. Simpson, Peter T. Simpson, Samuel Singer, Nasa Sinnott-Armstrong, Payal Sipahimalani, Tara Skelly, Marcel Smid, John A. Smith, Karen Smith‐McCune, Nicholas D. Socci, Heidi J. Sofia, Matthew G. Soloway, Lei Song, Anil K. Sood, Sharmila Sothi, Christos Sotiriou, Cameron M. Soulette, Paul N. Span(Howard Hughes Medical Institute), Paul T. Spellman(German Cancer Research Center), Nicola Sperandio(Broad Institute), Andrew J. Spillane, Oliver Spiro, Jonathan Spring, Johan Staaf, Peter F. Stadler(University of Cambridge), Peter Staib, Stefan G. Stark, Lucy Stebbings, Ólafur Andri Stefánsson, Oliver Stegle(Yale University), Lincoln D. Stein, Alasdair Stenhouse(Broad Institute), Chip Stewart(Broad Institute), Stephan Stilgenbauer, Miranda D. Stobbe, Michael R. Stratton, Jonathan R. Stretch, Adam J. Struck, Joshua M. Stuart, Henk G. Stunnenberg(Seoul National University Hospital), Hong Su(Seoul National University Hospital), Xiaoping Su(Seoul National University Hospital), Ren Sun, Stéphanie Sungalee, Hana Sušak, Akihiro Suzuki, Fred C.G.J. Sweep, Monika Szczepanowski, Holger Sültmann, Takashi Yugawa, Angela Tam(Heidelberg University), David Tamborero, Benita Kiat Tee Tan, Donghui Tan, Patrick Tan, Hiroko Tanaka, Hirokazu Taniguchi, Tomas Tanskanen, Maxime Tarabichi, Roy Tarnuzzer, Patrick Tarpey, Morgan L. Taschuk, Kenji Tatsuno, Simon Tavaré, Darrin F. Taylor, Amaro Taylor‐Weiner, Jon W. Teague, Bin Tean Teh, Varsha Tembe, Javier Temes, Kevin Thai, Sarah P. Thayer, Nina Thiessen, Gilles Thomas, Sarah Thomas, Alan Thompson, Alastair M. Thompson, John F. Thompson, R. Houston Thompson, Heather Thorne, Leigh B. Thorne(University of Cambridge), Adrian Thorogood, Grace Tiao, Nebojša Tijanić, Lee E. Timms, Roberto Tirabosco, Marta Tojo, Stefania Tommasi, Christopher W. Toon, Umut H. Toprak(Heidelberg University), David Torrents(Heidelberg University), Giampaolo Tortora(Universidade de Santiago de Compostela), Jörg Tost, Yasushi Totoki(Heidelberg University), David Townend, Nadia Traficante, Isabelle Treilleux, Jean-Rémi Trotta, Lorenz Trümper, Ming‐Sound Tsao, Tatsuhiko Tsunoda(Universidade de Santiago de Compostela), José M. C. Tubío(Universidade de Santiago de Compostela), Olga Tucker, Richard Turkington, Daniel J. Turner(Broad Institute), Andrew Tutt, Masaki Ueno, Naoto T. Ueno, Christopher B. Umbricht, Husen M. Umer, Tim Underwood, Lara Urban, Tomoko Urushidate, Tetsuo Ushiku, Liis Uusküla-Reimand, Alfonso Valencia, David Van Den Berg(Washington State University), Steven Van Laere(University of Cambridge), Peter Van Loo, Erwin G. Van Meir, Gert G. Van den Eynden, Theodorus van der Kwast, Naveen Vasudev, Miguél Vázquez, Ravikiran Vedururu, Umadevi Veluvolu, Shankar Vembu, Chao Li(University of Cambridge), Peter Vermeulen, Clare Verrill, Alain Viari(Heidelberg University), David Vicente, Caterina Vicentini(Beth Israel Deaconess Medical Center), K. VijayRaghavan, Juris Vīksna, Ricardo E. Vilain(Barcelona Supercomputing Center), Izar Villasante(Barcelona Supercomputing Center), Anne Vincent‐Salomon, Tapio Visakorpi, Douglas Voet, Paresh Vyas, Ignacio Vázquez-Garćıa(German Cancer Research Center), Nick M. Waddell(German Cancer Research Center), Nicola Waddell(German Cancer Research Center), Claes Wadelius(University of Copenhagen), Lina Wadi, Rabea Wagener(Institució Catalana de Recerca i Estudis Avançats), Jeremiah A. Wala(Broad Institute), Jian Wang, Jiayin Wang, Linghua Wang, Qi Wang, Wenyi Wang, Yumeng Wang, Zhining Wang, Paul Waring, Hans-Jörg Warnatz, Jonathan Warrell, Anne Y. Warren, Sebastian M. Waszak, David C. Wedge, Dieter Weichenhan(University of Cambridge), Paul Weinberger, John N. Weinstein(Charité - Universitätsmedizin Berlin), Joachim Weischenfeldt(Beth Israel Deaconess Medical Center), Daniel J. Weisenberger(Massachusetts General Hospital), Ian Welch, Michael C. Wendl, Johannes Werner, Justin P. Whalley(Heidelberg University), David A. Wheeler, Hayley C. Whitaker, Dennis A. Wigle, Matthew D. Wilkerson, Ashley Williams, James S. Wilmott, Gavin W. Wilson, Julie M. Wilson, Richard K. Wilson, Boris Winterhoff, Jeffrey A. Wintersinger, Maciej Wiznerowicz(Centre for Genomic Regulation), Stephan Wolf, Bernice H. Wong, Tina Wong, Winghing Wong, Youngchoon Woo, Scott Wood, Bradly G. Wouters, A. Jordan Wright, Derek Wright, Mark H. Wright, Chin‐Lee Wu, Dai‐Ying Wu, Guanming Wu, Jianmin Wu, Kui Wu(University of Chicago), Yang Wu, Zhenggang Wu(Cornell University), Xi Liu(Cornell University), Tian Xia, Qian Xiang(Cornell University), Xiao Xiao(University of Chicago), Rui Xing(Dana-Farber Cancer Institute), Heng Xiong, Qinying Xu, Yanxun Xu(Dana-Farber Cancer Institute), Hong Xue, Shinichi Yachida, Sergei Yakneen(Peking University), Rui Yamaguchi, Takafumi N. Yamaguchi, Masakazu Yamamoto, Shogo Yamamoto, Hiroki Yamaue(University of Chicago), Fan Yang(University of Chicago), Huanming Yang(University of Chicago), Jean Yang(University of Chicago), Liming Yang(University of Chicago), Lixing Yang(University of Chicago), Shanlin Yang(University of Chicago), Tsun-Po Yang(University of Chicago), Yang Yang(Cornell University), Xiaotong Yao(Cornell University), Marie‐Laure Yaspo, Lucy Yates, Christina Yau(Charité - Universitätsmedizin Berlin), Chen Ye, Kai Ye, Venkata Yellapantula(Seoul National University Hospital), Christopher J. Yoon(Seoul National University Hospital), Sung-Soo Yoon(Seoul National University Hospital), Fouad Yousif(Boston Children's Hospital), Jun Yu, Kaixian Yu, Willie Yu, Yingyan Yu(Bar-Ilan University), Ke Yuan, Yuan Yuan, Denis Yuen, Christina K. Yung, Olga Zaikova(Universidade de Santiago de Compostela), Jorge Zamora(Universidade de Santiago de Compostela), Marc Zapatka, Jean C. Zenklusen, Thorsten Zenz, Nikolajs Zeps(Dana-Farber Cancer Institute), Cheng-Zhong Zhang(Broad Institute), Fan Zhang(Dana-Farber Cancer Institute), Hailei Zhang(Dana-Farber Cancer Institute), Hongwei Zhang(Dana-Farber Cancer Institute), Hongxin Zhang(Dana-Farber Cancer Institute), Jiashan Zhang(Dana-Farber Cancer Institute), Jing Zhang(Dana-Farber Cancer Institute), Junjun Zhang(Dana-Farber Cancer Institute), Xiuqing Zhang(Dana-Farber Cancer Institute), Xuanping Zhang(Dana-Farber Cancer Institute), Yan Zhang(Dana-Farber Cancer Institute), Zemin Zhang, Zhongming Zhao, Liangtao Zheng, Xiuqing Zheng, Wanding Zhou, Yong Zhou(Peking University), Bin Zhu, Hongtu Zhu, Jingchun Zhu, Shida Zhu, Lihua Zou, Xueqing Zou, Anna DeFazio, Nicholas van As, Carolien H. M. van Deurzen, Marc J. van de Vijver(Charité - Universitätsmedizin Berlin), L. van’t Veer, Christian von Mering
Cited by 767Open Access
Abstract
Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer types have suggested that chromothripsis may be more common than initially inferred from low-resolution copy-number data. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), we analyze patterns of chromothripsis across 2,658 tumors from 38 cancer types using whole-genome sequencing data. We find that chromothripsis events are pervasive across cancers, with a frequency of more than 50% in several cancer types. Whereas canonical chromothripsis profiles display oscillations between two copy-number states, a considerable fraction of events involve multiple chromosomes and additional structural alterations. In addition to non-homologous end joining, we detect signatures of replication-associated processes and templated insertions. Chromothripsis contributes to oncogene amplification and to inactivation of genes such as mismatch-repair-related genes. These findings show that chromothripsis is a major process that drives genome evolution in human cancer.
Related Papers
No related papers found
Powered by citation graph analysis