Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

Manli Wang(Chinese Academy of Sciences), Ruiyuan Cao, Leike Zhang(Chinese Academy of Sciences), Xing‐Lou Yang(Chinese Academy of Sciences), Jia Liu(Chinese Academy of Sciences), Mingyue Xu(Chinese Academy of Sciences), Zhengli Shi(Chinese Academy of Sciences), Zhìhóng Hú(Chinese Academy of Sciences), Wu Zhong(National Institutes for Food and Drug Control), Gengfu Xiao(Chinese Academy of Sciences)
Cell Research
February 4, 2020
10.1038/s41422-020-0282-0
Cited by 7,377Open Access
Full Text

Abstract

In December 2019, a novel pneumonia caused by a previously
\nunknown pathogen emerged in Wuhan, a city of 11 million
\npeople in central China. The initial cases were linked to
\nexposures in a seafood market in Wuhan.1 As of January 27,
\n2020, the Chinese authorities reported 2835 confirmed cases in
\nmainland China, including 81 deaths. Additionally, 19 confirmed
\ncases were identified in Hong Kong, Macao and Taiwan, and 39
\nimported cases were identified in Thailand, Japan, South Korea,
\nUnited States, Vietnam, Singapore, Nepal, France, Australia
\nand Canada. The pathogen was soon identified as a novel
\ncoronavirus (2019-nCoV), which is closely related to sever acute
\nrespiratory syndrome CoV (SARS-CoV).2 Currently, there is no
\nspecific treatment against the new virus. Therefore, identifying
\neffective antiviral agents to combat the disease is urgently
\nneeded.

Related Papers

No related papers found

Powered by citation graph analysis