Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
Joana Carlevaro-Fita(University of Bern), Andrés Lanzós(University of Bern), Lars Feuerbach(German Cancer Research Center), Chen Hong(German Cancer Research Center), David Mas-Ponte(Universitat Pompeu Fabra), Jakob Skou Pedersen(Aarhus University), PCAWG Drivers and Functional Interpretation Group(Wellcome Sanger Institute), Federico Abascal(The University of Texas MD Anderson Cancer Center), Samirkumar B. Amin(University of Toronto), Gary D. Bader(Ontario Institute for Cancer Research), Jonathan Barenboim(Aarhus University Hospital), Rameen Beroukhim(RIKEN Center for Integrative Medical Sciences), Johanna Bertl(Technical University of Denmark), Keith A. Boroevich(Wellcome Sanger Institute), Søren Brunak(University of Bern), Peter J. Campbell(The University of Texas MD Anderson Cancer Center), Joana Carlevaro-Fita(University of Bern), Dimple Chakravarty(The University of Texas MD Anderson Cancer Center), Calvin Wing Yiu Chan(Korea Advanced Institute of Science and Technology), Ken Chen(Universitat Pompeu Fabra), Jung Kyoon Choi(Cornell University), Jordi Deu-Pons(Uppsala University), Priyanka Dhingra(German Cancer Research Center), Klev Diamanti(The University of Queensland), Lars Feuerbach(German Cancer Research Center), J. Lynn Fink(Institute for Research in Biomedicine), Nuno A. Fonseca(University of Milano-Bicocca), Joan Frigola(Peter MacCallum Cancer Centre), Carlo Gambacorti‐Passerini(Princeton University), Dale W. Garsed(Broad Institute), Mark Gerstein(Universitat Pompeu Fabra), Gad Getz(Aarhus University), Abel González-Pérez(Universitat Pompeu Fabra), Qianyun Guo(University of California, Santa Cruz), Marta Gut(Stanford University), David Haan(Broad Institute), Mark P. Hamilton(Yale University), Nicholas J. Haradhvala(University of Toronto), Arif Harmanci(German Cancer Research Center), Mohamed Helmy(Broad Institute), Carl Herrmann(Aarhus University), Julian M. Hess(Simon Fraser University), Asger Hobolth(German Cancer Research Center), Ermin Hodzic(Aarhus University Hospital), Chen Hong(Ontario Institute for Cancer Research), Henrik Hornshøj(Technical University of Denmark), Keren Isaev(University of Bern), José M. G. Izarzugaza(RIKEN Center for Integrative Medical Sciences), Rory Johnson(University of Bern), Todd A. Johnson(Aarhus University Hospital), Malene Juul(Memorial Sloan Kettering Cancer Center), Randi Istrup Juul(SIB Swiss Institute of Bioinformatics), André Kahles(Broad Institute), Abdullah Kahraman(Cornell University), Manolis Kellis(Broad Institute), Ekta Khurana(National Cancer Center), Jaegil Kim(Samsung (South Korea)), Jong K. Kim(Uppsala University), Young-Wook Kim(European Bioinformatics Institute), Jan Komorowski(European Bioinformatics Institute), Jan O. Korbel(University of Bern), Sushant Kumar(University of Gothenburg), Andrés Lanzós(University of Bern), Erik G. Larsson(Memorial Sloan Kettering Cancer Center), Michael S. Lawrence(Yale University), Dong-Hoon Lee(Yale University), Kjong-Van Lehmann(Broad Institute), Shantao Li(Memorial Sloan Kettering Cancer Center), Xiaotong Li(Yale University), Ziao Lin(Yale University), Eric Minwei Liu(Aarhus University Hospital), Lucas Lochovsky(Ghent University), Shaoke Lou(Wellcome Sanger Institute), Tobias Madsen(Cornell University), Kathleen Marchal(Broad Institute), Iñigo Martincorena(Yale University), Alexander Martinez‐Fundichely(Yale University), Yosef E. Maruvka(Universitat Pompeu Fabra), Patrick D. McGillivray(Universitat Pompeu Fabra), William Meyerson(RIKEN Center for Integrative Medical Sciences), Ferran Muiños(Aarhus University Hospital), Loris Mularoni(Ontario Institute for Cancer Research), Hidewaki Nakagawa(Samsung (South Korea)), Morten Muhlig Nielsen(Sangmyung University), Marta Paczkowska(Aarhus University Hospital), Keunchil Park(Universitat Pompeu Fabra), Kiejung Park(Spanish National Cancer Research Centre), Jakob Skou Pedersen(Aarhus University Hospital), Oriol Pich(Princeton University), Tirso Pons(Ontario Institute for Cancer Research), Sergio Pulido-Tamayo(Institute for Research in Biomedicine), Benjamin J. Raphael(Princeton University), Jüri Reimand(Broad Institute), Iker Reyes-Salazar(University of Bern), Matthew A. Reyna(Universitat Pompeu Fabra), Esther Rheinbay(Universitat Pompeu Fabra), Mark A. Rubin(Simon Fraser University), Carlota Rubio-Pérez(Broad Institute), Radhakrishnan Sabarinathan(Yale University), S. Cenk Sahinalp(Memorial Sloan Kettering Cancer Center), Gordon Saksena(Broad Institute), Leonidas Salichos(The University of Melbourne), Chris Sander(Broad Institute), Steven E. Schumacher(Harvard University), Mark Shackleton(Indiana University Bloomington), Ofer Shapira(Ontario Institute for Cancer Research), Ciyue Shen(University of Copenhagen), Raunak Shrestha(German Cancer Research Center), Shimin Shuai(Stanford University), Nikos Sidiropoulos(Ontario Institute for Cancer Research), Lina Sieverling(University of California, Santa Cruz), Nasa Sinnott-Armstrong(Universitat Pompeu Fabra), Lincoln Stein(Broad Institute), Joshua M. Stuart(Tokyo Medical and Dental University), David Tamborero(Uppsala University), Grace Tiao(Tallinn University of Technology), Tatsuhiko Tsunoda(Barcelona Supercomputing Center), Husen M. Umer(Barcelona Supercomputing Center), Liis Uusküla-Reimand(Ghent University), Alfonso Valencia(Uppsala University), Miguél Vázquez(Ontario Institute for Cancer Research), Lieven P. C. Verbeke(Xi'an Jiaotong University), Claes Wadelius(Yale University), Lina Wadi(European Molecular Biology Laboratory), Jiayin Wang(University of Copenhagen), Jonathan Warrell(Baylor College of Medicine), Sebastian M. Waszak(Oregon Health & Science University), Joachim Weischenfeldt(Chinese University of Hong Kong), David A. Wheeler(Yale University), Guanming Wu(Xi'an Jiaotong University), Jun Yu(Yale University), Jing Zhang(University of Houston), Xuanping Zhang(Northwestern University), Yan Zhang(University of Zurich), Zhongming Zhao(University of Bern), Lihua Zou(University of Helsinki), Christian von Mering(Wellcome Sanger Institute), Rory Johnson(University of Bern), Lauri A. Aaltonen(The University of Tokyo), Federico Abascal(Wellcome Sanger Institute), Adam Abeshouse(University of Chicago), Hiroyuki Aburatani(Keimyung University Dongsan Medical Center), David J. Adams(Gachon University Gil Medical Center), Nishant Agrawal(Hiroshima University), Keun Soo Ahn(The University of Texas MD Anderson Cancer Center), Sung‐Min Ahn(The University of Texas MD Anderson Cancer Center), Hiroshi Aikata(Memorial Sloan Kettering Cancer Center), Rehan Akbani(King Faisal Specialist Hospital & Research Centre), Kadir C. Akdemir(Spanish National Cancer Research Centre), Hikmat Al‐Ahmadie(Universität Hamburg), Sultan T. Al‐Sedairy(Ontario Institute for Cancer Research), Fátima Al‐Shahrour(The University of Texas MD Anderson Cancer Center), Malik Alawi(Wellcome Sanger Institute), Monique Albert(Canada's Michael Smith Genome Sciences Centre), Kenneth Aldape(The University of Melbourne), Ludmil B. Alexandrov(Universidade de Santiago de Compostela), Adrian Ally(Royal National Orthopaedic Hospital), Kathryn Alsop(Jackson Laboratory), Eva G. Álvarez(Ontario Institute for Cancer Research), Fernanda Amary(Universität Ulm), Samirkumar B. Amin(The University of Queensland), Brice Aminou(Salford Royal NHS Foundation Trust), Ole Ammerpohl, Matthew J. Anderson(Oregon Health & Science University), Yeng Ang, Davide Antonello(James S. McDonnell Foundation), Pavana Anur, Samuel Aparício, Elizabeth L. Appelbaum(Hiroshima University), Yasuhito Arai(Tokyo Women's Medical University), Axel Aretz(Memorial Sloan Kettering Cancer Center), Koji Arihiro(Los Alamos National Laboratory), Shun‐ichi Ariizumi(University Health Network), Joshua Armenia(German Cancer Research Center), Laurent Arnould(Ontario Institute for Cancer Research), L. Sylvia(Universität Ulm), Yassen Assenov(University of North Carolina at Chapel Hill), Gurnit Atwal(Oslo University Hospital), Sietse Aukema(Ontario Institute for Cancer Research), J. Todd Auman(Consorci Institut D'Investigacions Biomediques August Pi I Sunyer), Miriam R. R. Aure(University of Toronto), Philip Awadalla(University of Cambridge), Marta Aymerich(James S. McDonnell Foundation), Gary D. Bader(University of Glasgow), Adrian Baez‐Ortega(Canada's Michael Smith Genome Sciences Centre), Matthew H. Bailey(University of North Carolina at Chapel Hill), Peter J. Bailey(Broad Institute), Miruna Balasundaram(University of Leeds), Saianand Balu, Pratiti Bandopadhayay(The University of Queensland), Rosamonde E. Banks(Ontario Institute for Cancer Research), Stefano Barbi(University Hospitals of Cleveland), Andrew P. Barbour(Gloucestershire Royal Hospital), Jonathan Barenboim(European Bioinformatics Institute), Jill S. Barnholtz‐Sloan(Ontario Institute for Cancer Research), Hugh Barr(Barcelona Supercomputing Center), Elisabet Barrera, John M.S. Bartlett(University of Calgary), Javier Bartolomé(Oslo University Hospital), Claudio Bassi(Ontario Institute for Cancer Research), Oliver F. Bathe(Johns Hopkins University), Daniel Baumhoer(European Bioinformatics Institute), Prashant Bavi(Royal Stoke University Hospital), Stephen B. Baylin(Ontario Institute for Cancer Research), Wojciech Bażant(Wellcome Sanger Institute), Duncan Beardsmore(La Trobe University), Timothy A. Beck(Chinese Academy of Sciences), Sam Behjati(Genome Canada), Andreas Behren(Universitat Pompeu Fabra), Beifang Niu(Buck Institute for Research on Aging), Cindy Bell(Duke Medical Center), Sergi Beltrán(Medizinische Hochschule Hannover), Christopher C. Benz(University of California San Diego), Andrew Berchuck(Cedars-Sinai Medical Center), Anke K. Bergmann(Queen Mary University of London), Erik N. Bergstrom(Leipzig University), Benjamin P. Berman(Broad Institute), Daniel M. Berney(University of Southern California), Stephan H. Bernhart, Rameen Beroukhim(Aarhus University), Mario Berríos(Secretaria de Salud), Samantha Bersani(Ontario Institute for Cancer Research), Johanna Bertl(Wellcome Sanger Institute), Miguel Betancourt(University of Glasgow), Vinayak Bhandari(German Cancer Research Center), Shriram G. Bhosle(Duke Medical Center), Andrew V. Biankin(Leipzig University), Matthias Bieg(European Bioinformatics Institute), Darell D. Bigner(Massachusetts General Hospital), Hans Binder(National Institute of Biomedical Genomics), Ewan Birney(Oslo University Hospital), Michael J. Birrer(University of North Carolina at Chapel Hill), Nidhan K. Biswas(University of North Carolina at Chapel Hill), Bodil Bjerkehagen, Tom Bodenheimer(Institute of Cancer Research), Lori Boice(Duke-NUS Medical School), Giada Bonizzato(University of Southern California), Johann S. de Bono(Lund University), Arnoud Boot(Heinrich Heine University Düsseldorf), Moiz S. Bootwalla(RIKEN Center for Integrative Medical Sciences), Åke Borg(Ontario Institute for Cancer Research), Arndt Borkhardt(Friedrich-Ebert-Krankenhaus), Keith A. Boroevich(Yale University), Ivan Borozan(Universitat Pompeu Fabra), Christoph W. Borst(University of Oxford), Marcus Bosenberg(McGill University), Mattia Bosio(Ontario Institute for Cancer Research), Jacqueline Boultwood(Tampere University Hospital), Guillaume Bourque(Wellcome Sanger Institute), Paul C. Boutros(Canada's Michael Smith Genome Sciences Centre), G. Steven Bova(The University of Melbourne), David Bowen(Centre Léon Bérard), Reanne Bowlby(European Bioinformatics Institute), David D.L. Bowtell(Fox Chase Cancer Center), Sandrine Boyault(European Bioinformatics Institute), Rich Boyce(Centre international de recherche sur le cancer), Jeffrey M. Boyd(University of East Anglia), Alvis Brāzma(Radboud University Nijmegen), Paul Brennan(University of Toronto), Daniel S. Brewer(The University of Texas MD Anderson Cancer Center), Arie B. Brinkman(Brigham and Women's Hospital), Robert G. Bristow(Johns Hopkins University), Russell R. Broaddus(The Netherlands Cancer Institute), Jane E. Brock(Broad Institute), Malcolm V. Brock(Canada's Michael Smith Genome Sciences Centre), Annegien Broeks(German Cancer Research Center), Angela N. Brooks(University of Copenhagen), Denise Brooks(The University of Queensland), Benedikt Brors(Universidade de Santiago de Compostela), Søren Brunak(Oregon Health & Science University), Timothy J. C. Bruxner(German Cancer Research Center), Alicia L. Bruzos(Bundesministerium für Forschung, Technologie und Raumfahrt), Alex Buchanan(Broad Institute), Ivo Buchhalter(The University of Sydney), Christiane Buchholz(University Hospital Münster), Susan Bullman(Johns Hopkins University), Hazel Burke(Broad Institute), Birgit Burkhardt(Stanford University), Kathleen H. Burns(Wellcome Sanger Institute), John Busanovich(University of California, San Francisco), Carlos D. Bustamante(Ontario Institute for Cancer Research), Adam P. Butler(Oslo University Hospital), Atul J. Butte(National Institutes of Health), Niall J. Byrne(European Bioinformatics Institute), Anne‐Lise Børresen‐Dale(Royal Marsden NHS Foundation Trust), Rory Johnson(European Bioinformatics Institute), Andy Cafferkey(University of Cambridge), Declan Cahill(Institut Gustave Roussy), Claudia Calabrese(Institute of Cancer Research), Carlos Caldas(Wellcome Sanger Institute), Fabien Calvo(Consorci Institut D'Investigacions Biomediques August Pi I Sunyer), Niedzica Camacho, Peter J. Campbell(The University of Texas MD Anderson Cancer Center), Elı́as Campo(University of Michigan), Cinzia Cantù(University of Bern), Shaolong Cao(Canada's Michael Smith Genome Sciences Centre), Thomas E. Carey, Joana Carlevaro-Fita(University of Bern), Rebecca Carlsen(La Trobe University), Ivana Cataldo(University of Alabama at Birmingham), Mario Cazzola(Toronto General Hospital), Jonathan Cebon(The University of Texas MD Anderson Cancer Center), Robert J. Cerfolio(University of Tasmania), Dianne Chadwick(German Cancer Research Center), Dimple Chakravarty(University of Ottawa), Drc Chalmers(Ontario Institute for Cancer Research), Calvin Wing Yiu Chan(Mayo Clinic in Arizona), Kin Chan(Garvan Institute of Medical Research), Michelle Chan‐Seng‐Yue(National Institutes of Health), Vishal S. Chandan(Garvan Institute of Medical Research), David K. Chang(Ontario Institute for Cancer Research), Stephen J. Chanock(Johns Hopkins University), Lorraine A. Chantrill(Hiroshima University), Aurélien Chateigner(Memorial Sloan Kettering Cancer Center), Nilanjan Chatterjee(University of California, San Francisco), Kazuaki Chayama(The University of Texas MD Anderson Cancer Center), Hsiao-Wei Chen(The University of Texas MD Anderson Cancer Center), Jieming Chen(University of California San Diego), Ken Chen(Broad Institute), Yiwen Chen(Mayo Clinic), Zhaohong Chen(The University of Sydney), Andrew D. Cherniack(University of Cambridge), Jeremy Chien(Broad Institute), Yoke-Eng Chiew, Suet‐Feung Chin(Korea Advanced Institute of Science and Technology), Juok Cho(Electronics and Telecommunications Research Institute), Sunghoon Cho(Institut National du Cancer), Jung Kyoon Choi(The University of Texas MD Anderson Cancer Center), Wan Choi(National Cancer Centre Singapore), Christine Chomienne(The University of Sydney), Zechen Chong(The University of Queensland), Su Pin Choo(The University of Melbourne), Angela Chou(Canada's Michael Smith Genome Sciences Centre), Angelika N. Christ(Broad Institute), Elizabeth L. Christie(Broad Institute), Eric Chuah, Carrie Cibulskis(Wellcome Sanger Institute), Kristian Cibulskis(University Hospital Schleswig-Holstein), Sara Cingarlini(Ontario Institute for Cancer Research), Peter Clapham(University of Auckland), Alexander Claviez(Royal Children's Hospital), Sean P. Cleary, Nicole Cloonan(University Health Network), Marek Cmero(University of Glasgow), Colin C. Collins(University of East Anglia), Ashton A. Connor(Johns Hopkins University), Susanna L. Cooke, Colin S. Cooper(James S. McDonnell Foundation), Leslie Cope(Victorian Institute of Forensic Medicine), Vincenzo Corbo(Harvard University), Matthew G. Cordes(Baylor College of Medicine), Stephen Cordner(The University of Melbourne), Isidro Cortés‐Ciriano(University of California, Santa Cruz), Kyle R. Covington(Broad Institute), Prue A. Cowin(Baylor College of Medicine), Brian Craft(University of Cologne), David Craft(International Genomics Consortium), Chad J. Creighton(Duke-NUS Medical School), Yupeng Cun(Ontario Institute for Cancer Research), Erin Curley(The University of Texas MD Anderson Cancer Center), Ioana Cutcutache(The University of Sydney), Karolina Czajka(Johns Hopkins University), Bogdan Czerniak(University of Verona), Rebecca A. Dagg(SIB Swiss Institute of Bioinformatics), Ludmila Danilova(Wellcome Sanger Institute), Maria Vittoria Davì(University of North Carolina at Chapel Hill), Natalie R. Davidson(Seven Bridges Genomics (United States)), Helen Davies(Wellcome Sanger Institute), Ian J. Davis(Stanford University), Brandi N. Davis‐Dusenbery(The University of Sydney), Kevin J. Dawson(Broad Institute), Francisco M. De La Vega(University of Padua), Ricardo De Paoli‐Iseppi(University of Geneva), Timothy Defreitas(National Institutes of Health), Angelo Paolo Dei Tos(The Francis Crick Institute), Olivier Delaneau(Universitat Pompeu Fabra), John A. Demchok(Genome Institute of Singapore), Jonas Demeulemeester(Royal Marsden NHS Foundation Trust), German Demidov(Ontario Institute for Cancer Research), Deniz Demircioğlu(The Francis Crick Institute), Nening M. Dennis(The Francis Crick Institute), Robert E. Denroche(Massachusetts General Hospital), Stefan C. Dentro(University of Toronto), Nikita Desai(Institut Jules Bordet), Vikram Deshpande(Universitat Pompeu Fabra), Amit G. Deshwar(Canada's Michael Smith Genome Sciences Centre), Christine Desmedt(Princess Margaret Cancer Centre), Jordi Deu-Pons(Cornell University), Noreen Dhalla(Shadyside Hospital), Neesha C. Dhani(Wellesley College), Priyanka Dhingra(Uppsala University), Rajiv Dhir(James S. McDonnell Foundation), Anthony DiBiase(Hefei University of Technology), Klev Diamanti(Cedars-Sinai Medical Center), Li Ding(University of Antwerp), Shuai Ding(Baylor College of Medicine), Huy Q. Dinh, Luc Dirix(University of California San Diego), HarshaVardhan Doddapaneni(University of Pennsylvania), Nilgun Donmez(Universitat Pompeu Fabra), Michelle T. Dow(University of Cambridge), Ronny Drapkin(Wellcome Sanger Institute), Oliver Drechsel(Royal Marsden NHS Foundation Trust), Ruben M. Drews(Barcelona Supercomputing Center), Serge Serge(Broad Institute), Tim Dudderidge(Wellcome Trust), Ana Dueso-Barroso(Ontario Institute for Cancer Research), Andrew Dunford(University of Glasgow), Michael Dunn(QIMR Berghofer Medical Research Institute), Lewis Jonathan Dursi(Ontario Institute for Cancer Research), Fraser R. Duthie(University of Cambridge), Ken Dutton‐Regester(Prostate Cancer Canada), Jenna Eagles(University of Cambridge), Douglas F. Easton(Institute of Cancer Research), Stuart Edmonds(Royal Marsden NHS Foundation Trust), Paul A. Edwards(Lund University), Sandra E. Edwards(Heidelberg University), Rosalind A. Eeles(German Cancer Research Center), Anna Ehinger(The University of Texas MD Anderson Cancer Center), Juergen Eils(University of Cambridge), Roland Eils(Oregon Health & Science University), Adel K. El‐Naggar(European Molecular Biology Laboratory), Matthew Eldridge(Centre for Genomic Regulation), Kyle Ellrott(Ontario Institute for Cancer Research), Serap Erkek(Centre for Genomic Regulation), Geòrgia Escaramís(The University of Melbourne), Shadrielle M. G. Espiritu(Icelandic Cancer Society), Xavier Estivill(Cornell University), Dariush Etemadmoghadam(Xijing Hospital), Jorunn E. Eyfjord(The University of Texas MD Anderson Cancer Center), Bishoy M. Faltas(Massachusetts General Hospital), Daiming Fan(University of California San Diego), Yu Fan(University of Padua), William C. Faquin(Dana-Farber Cancer Institute), Claudiu Farcas(Rigshospitalet), Matteo Fassan(Ontario Institute for Cancer Research), Aquila Fatima(National Institutes of Health), Francesco Favero(The University of Melbourne), Nodirjon Fayzullaev(National Institutes of Health), Ina Felau(Ontario Institute for Cancer Research), Sián Fereday(German Cancer Research Center), Martin L. Ferguson(Australian Institute of Tropical Health and Medicine), Vincent Ferretti(The University of Queensland), Lars Feuerbach(German Cancer Research Center), Matthew A. Field(Royal Marsden NHS Foundation Trust), J. Lynn Fink(The Francis Crick Institute), Gaetano Finocchiaro(Bioplatforms Australia), Cyril Fisher(University of Cambridge), Matthew W. Fittall(London Cancer), Anna Fitzgerald(Princess Margaret Cancer Centre), Rebecca C. Fitzgerald(European Bioinformatics Institute), Adrienne M. Flanagan(Cancer Genomics Centre), Neil Fleshner(The University of Queensland), Paul Flicek(European Bioinformatics Institute), John A. Foekens(University of Liverpool), Kwun M. Fong(Ontario Institute for Cancer Research), Nuno A. Fonseca(Ontario Institute for Cancer Research), Christopher S. Foster(Broad Institute), Natalie S. Fox(Bar-Ilan University), Michael Fraser(University of Florida), Scott Frazer(Institute for Research in Biomedicine), Milana Frenkel‐Morgenstern(James S. McDonnell Foundation), William A. Friedman(RIKEN Center for Integrative Medical Sciences), Joan Frigola(RIKEN Center for Integrative Medical Sciences), Catrina C. Fronick(The University of Tokyo), Akihiro Fujimoto(James S. McDonnell Foundation), Masashi Fujita(James S. McDonnell Foundation), Masashi Fukayama(RIKEN Center for Integrative Medical Sciences), Lucinda A. Fulton(The University of Texas MD Anderson Cancer Center), Robert S. Fulton(European Bioinformatics Institute), Mayuko Furuta(Broad Institute), P. Andrew Futreal(Ontario Institute for Cancer Research), Anja Füllgrabe(University of Milano-Bicocca), Stacey Gabriel(Memorial Sloan Kettering Cancer Center), Steven Gallinger(BGI Group (China)), Carlo Gambacorti‐Passerini(Dana-Farber Cancer Institute), Jianjiong Gao(Oslo University Hospital), Shengjie Gao(Wellcome Sanger Institute), Levi A. Garraway(The University of Melbourne), Øystein Garred(Broad Institute), Erik Garrison(Barcelona Supercomputing Center), Dale W. Garsed(Jackson Laboratory), Nils Gehlenborg(National Institutes of Health), Josep L. L. Gelpi(German Cancer Research Center), Joshy George(The University of Texas MD Anderson Cancer Center), Daniela S. Gerhard(Princeton University), Clarissa Gerhäuser(European Bioinformatics Institute), Jeffrey E. Gershenwald(Massachusetts General Hospital), Mark Gerstein(Wellcome Sanger Institute), Moritz Gerstung(Memorial Sloan Kettering Cancer Center), Gad Getz(Mayo Clinic in Arizona), Mohammed Ghori(Baylor College of Medicine), Ronald Ghossein(Ontario Institute for Cancer Research), Nasra H. Giama(Garvan Institute of Medical Research), Richard A. Gibbs(University of Oxford), Bob Gibson(Memorial Sloan Kettering Cancer Center), Anthony J. Gill(Wellcome Sanger Institute), Pelvender Gill(Cambridge University Hospitals NHS Foundation Trust), Dilip D. Giri(University of Würzburg), Dominik Głodzik(University of California, Santa Cruz), Vincent J. Gnanapragasam(University of Miami), Maria Elisabeth Goebler(European Bioinformatics Institute), Mary J. Goldman(Universitat Pompeu Fabra), Carmen Gómez(National Institute of Environmental Health Sciences), Santiago González(St Thomas' Hospital), Abel González-Pérez(Osaka International Cancer Institute), Dmitry A. Gordenin(Washington University in St. Louis), James Gossage(Lund University), Kunihito Gotoh(University of Glasgow), Ramaswamy Govindan(Ontario Institute for Cancer Research), Dorthe Grabau(University of Cambridge), Janet S. Graham(National Institutes of Health), Robert C. Grant(European Bioinformatics Institute), Anthony R. Green(University of Cambridge), Eric Green, Liliana Greger(The University of Melbourne), Nicola Grehan(University of Chicago), Sonia Grimaldi(Leibniz Institute of Virology (LIV)), Sean M. Grimmond(Memorial Sloan Kettering Cancer Center), Robert L. Grossman(Aarhus University), Adam Grundhoff(Broad Institute), Gunes Gundem(Government of India), Qianyun Guo(Centre for Genomic Regulation), Manaswi Gupta(Universitat Pompeu Fabra), Shailja Gupta(Genome Institute of Singapore), Marta Gut(Broad Institute), Marta Gut(Christian-Albrechts-Universität zu Kiel), Jonathan Göke(University of California, Santa Cruz), Gavin Ha(Friedrich-Ebert-Krankenhaus), Andrea Haake(The Francis Crick Institute), David Haan(Brandeis University), Siegfried Haas(European Molecular Biology Laboratory), Kerstin Haase, James E. Haber(Ontario Institute for Cancer Research), Nina Habermann, Faraz Hach(University of Oxford), Syed Haider(The University of Melbourne), Natsuko Hama(Stanford University), Freddie C. Hamdy(The University of Texas Health Science Center at Houston), Anne Hamilton(Imperial College London), Mark P. Hamilton(Goethe University Frankfurt), Leng Han(Massachusetts General Hospital), George B. Hanna(UC San Diego Health System), Martin Hansmann(The University of Queensland), Nicholas J. Haradhvala(The University of Texas Health Science Center at Houston), Olivier Harismendy, Ivon Harliwong, Arif O. Harmanci(University of California, Santa Cruz), Eoghan Harrington(University of Cambridge), Takanori Hasegawa(Wakayama Medical University), David Haussler, Steve Hawkins(University of North Carolina at Chapel Hill), Shinya Hayami(Salford Royal NHS Foundation Trust), Shuto Hayashi(The University of Sydney), D. Neil Hayes(Royal Marsden NHS Foundation Trust), Stephen J. Hayes(Peking University), Nicholas K. Hayward(Children's Hospital of Philadelphia), Steven Hazell(Universitat Pompeu Fabra), Yao He(Princess Margaret Cancer Centre), Allison P. Heath(The University of Texas MD Anderson Cancer Center), Simon Heath(Broad Institute), David W. Hedley(German Cancer Research Center), Apurva M. Hegde(Memorial Sloan Kettering Cancer Center), David I. Heiman(Ontario Institute for Cancer Research), Michael C. Heinold(Karolinska Institutet), Zachary Heins(University of Toronto), Lawrence E. Heisler(Hallym University), Eva Hellström‐Lindberg(University of North Carolina at Chapel Hill), Mohamed Helmy(Universitat Pompeu Fabra), Seong Gu Heo(Heidelberg University), Austin J. Hepperla(The University of Sydney), José María Heredia‐Genestar(Massachusetts General Hospital), Carl Herrmann(Icelandic Cancer Society), Peter Hersey(Wellcome Sanger Institute), Julian M. Hess(Hokkaido University), Hólmfríður Hilmarsdóttir(Tokyo National Hospital), Jonathan Hinton(University of North Carolina at Chapel Hill), Satoshi Hirano(Aarhus University), Nobuyoshi Hiraoka(Simon Fraser University), Katherine A. Hoadley(Heinrich Heine University Düsseldorf), Asger Hobolth(Leipzig University), Ermin Hodzic(The University of Melbourne), Jessica I. Hoell(University of Southern California), Steve Hoffmann(Centre for Genomic Regulation), Oliver Hofmann(University of Nebraska Medical Center), Andrea Holbrook(The University of Queensland), Aliaksei Z. Holik(Canada's Michael Smith Genome Sciences Centre), Michael A. Hollingsworth(Broad Institute), Oliver Wendell Holmes(Hallym University), Robert A. Holt(Syneos Health (South Korea)), Chen Hong(German Cancer Research Center), Eun Pyo Hong(Aarhus University Hospital), Jongwhi H. Hong, Gerrit K. Hooijer(BGI Group (China)), Henrik Hornshøj(German Cancer Research Center), Fumie Hosoda(Cambridge University Hospitals NHS Foundation Trust), Yong Hou(University of North Carolina at Chapel Hill), Volker Hovestadt(Johns Hopkins University), William Howat(Baylor College of Medicine), Alan P. Hoyle(Hong Kong University of Science and Technology), Ralph H. Hruban(National Institutes of Health), Taobo Hu(James S. McDonnell Foundation), Taobo Hu(University of North Carolina at Chapel Hill), Xing Hua(Duke-NUS Medical School), Kuan‐lin Huang(Ontario Institute for Cancer Research), Mei Huang(Shenzhen Bioeasy Biotechnology (China)), Mi Ni Huang(European Molecular Biology Laboratory), Vincent Huang(Ontario Institute for Cancer Research), Yi Huang(Charité - Universitätsmedizin Berlin), Wolfgang Huber(The University of Sydney), Thomas J. Hudson(BC Cancer Agency), Michael Hummel(Edinburgh Royal Infirmary), Jillian A. Hung(Memorial Sloan Kettering Cancer Center), David Huntsman(Max Delbrück Center), Ted R. Hupp(German Cancer Research Center), Jason T. Huse(National Institutes of Health), Matthew R. Huska(Heidelberg University), Barbara Hutter(Memorial Sloan Kettering Cancer Center), Carolyn M. Hutter(German Cancer Research Center), Daniel Hübschmann(Cornell University), Christine A. Iacobuzio–Donahue, Charles D. Imbusch(Johns Hopkins University), Marcin Imieliński(University of Toronto), Seiya Imoto(The University of Tokyo), William B. Isaacs(German Cancer Research Center), Keren Isaev(University of California San Diego), Shumpei Ishikawa(Michael E. DeBakey VA Medical Center), Murat Iskar(Seven Bridges Genomics (United States)), S. M. Ashiqul Islam(Technical University of Denmark), Michael Ittmann(Hanyang University), Sinisa Ivkovic(The University of Sydney), José M. G. Izarzugaza(Glasgow Royal Infirmary), Jocelyne Jacquemier(Ontario Institute for Cancer Research), Valerie Jakrot(Asan Medical Center), Nigel B. Jamieson(Baylor College of Medicine), Gun Ho Jang(James S. McDonnell Foundation), Se Jin Jang(University of North Carolina at Chapel Hill), Joy C. Jayaseelan, Reyka G. Jayasinghe(Ontario Institute for Cancer Research), Stuart R. Jefferys(Electronics and Telecommunications Research Institute), Karine Jegalian(European Molecular Biology Laboratory), Jennifer L. Jennings(NorthShore University HealthSystem), Seung-Hyup Jeon(Ontario Institute for Cancer Research), Lara Jerman(QIMR Berghofer Medical Research Institute), Yuan Ji(Garvan Institute of Medical Research), Wei Jiao(Ontario Institute for Cancer Research), Peter A. Johansson(University of Bern), Amber L. Johns(RIKEN Center for Integrative Medical Sciences), Jeremy Johns(The Francis Crick Institute), Rory Johnson(University of Bern), Todd A. Johnson(Icelandic Cancer Society), Clemency Jolly(University of North Carolina at Chapel Hill), Yann Joly(Wellcome Sanger Institute), Jón G. Jónasson(German Cancer Research Center), Corbin D. Jones(Cancer Research Horizons), David R. Jones(Canada's Michael Smith Genome Sciences Centre), David Jones(The Netherlands Cancer Institute), Nic Jones(Korea Advanced Institute of Science and Technology), Steven J.M. Jones, Jos Jonkers, Young Seok Ju(Aarhus University Hospital), Hartmut Juhl(Aarhus University Hospital), Jongsun Jung, Malene Juul(German Cancer Research Center), Randi Istrup Juul(German Cancer Research Center), Randi Istrup Juul(SIB Swiss Institute of Bioinformatics), Natalie Jäger(University of Zurich), Rolf Kabbe(Institute of Genetics and Cancer), André Kahles(The University of Sydney), Abdullah Kahraman(Ontario Institute for Cancer Research), Vera B. Kaiser(German Cancer Research Center), Hojabr Kakavand(Keimyung University Dongsan Medical Center), Sangeetha Kalimuthu(University of Oxford), Christof von Kalle(Cedars-Sinai Medical Center), Koo Jeong Kang(University of Zagreb), Katalin Karászi(University Hospital Schleswig-Holstein), Beth Y. Karlan(Canada's Michael Smith Genome Sciences Centre), Rosa Karlić(The University of Queensland), Dennis Karsch(Tokyo National Hospital), Katayoon Kasaian(National Cancer Centre Japan), Karin S. Kassahn(The University of Tokyo), Hitoshi Katai(Hiroshima University), Mamoru Kato(University College London), Hiroto Katoh(The University of Queensland), Yoshiiku Kawakami(Skolkovo Institute of Science and Technology), Jonathan D. Kay(European Bioinformatics Institute), Stephen H. Kazakoff(National Institutes of Health), Marat D. Kazanov(Melanoma Institute Australia), Maria Keays(Massachusetts Institute of Technology), Electron Kebebew(The University of Sydney), Richard Kefford(The University of Sydney), Manolis Kellis(German Cancer Research Center), James G. Kench(Barking, Havering And Redbridge University Hospitals NHS Trust), Catherine J. Kennedy(Royal Marsden NHS Foundation Trust), Jules N. A. Kerssemakers, David Khoo(Cornell University), Vincent Khoo(University College London), Narong Khuntikeo(National Cancer Center), Ekta Khurana(Ewha Womans University), Helena Kilpinen(Hanyang University), Hark Kyun Kim(Electronics and Telecommunications Research Institute), Hyung‐Lae Kim(Broad Institute), Hyung-Yong Kim(University of California San Diego), Hyunghwan Kim(National Cancer Center), Jaegil Kim(Samsung (South Korea)), Jihoon Kim(Brigham and Women's Hospital), Jong K. Kim(Christian-Albrechts-Universität zu Kiel), Young-Wook Kim(German Cancer Research Center), Tari A. King(National Institute of Environmental Health Sciences), Wolfgang Hiddemann(Wellcome Sanger Institute), Kortine Kleinheinz(University Hospital Schleswig-Holstein), Leszek J. Klimczak(McGill University and Génome Québec Innovation Centre), Stian Knappskog(Seoul National University Hospital), Michael Kneba(Uppsala University), Bartha Maria Knoppers(The University of Tokyo), Youngil Koh, Jan Komorowski(Hanyang University), Daisuke Komura(Hopp Children's Cancer Center Heidelberg), Mitsuhiro Komura(European Bioinformatics Institute), Gu Kong(Baylor College of Medicine), Marcel Kool(German Cancer Research Center), Jan O. Korbel(German Cancer Research Center), Viktoriya Korchina(National Institutes of Health), Andrey Korshunov(Institute of Cancer Research), Michael Koscher(University of California San Diego), Roelof Koster(Seven Bridges Genomics (United States)), Zsofia Kote‐Jarai(Wellcome Sanger Institute), Antonios Koures(Leipzig University), Milena Kovačević(Leipzig University), Bárbara Kremeyer(The University of Texas MD Anderson Cancer Center), Helene Kretzmer(University of Göttingen), Markus Kreuz(Broad Institute), Savitri Krishnamurthy(Royal Marsden NHS Foundation Trust), Dieter Kube(European Bioinformatics Institute), Kiran A. Kumar(Hong Kong University of Science and Technology), Pardeep Kumar(Memorial Sloan Kettering Cancer Center), Sushant Kumar(Broad Institute), Yogesh Kumar(University of Duisburg-Essen), Ritika Kundra(Karolinska Institutet), Kirsten Kübler(University of Southern California), Ralf Küppers(Van Andel Institute), Jesper Lagergren(The University of Queensland), Phillip H. Lai(Ontario Institute for Cancer Research), Peter W. Laird(Ontario Institute for Cancer Research), Sunil R. Lakhani(Ontario Institute for Cancer Research), Christopher M. Lalansingh(University of Oxford), Emilie Lalonde(Broad Institute), Fabien C. Lamaze(University of Cologne), Adam Lambert, Eric Lander(Oslo University Hospital), Pablo Landgraf(University of Bern), Luca Landoni(Institut Jules Bordet), Anita Langerød(University of Gothenburg), Andrés Lanzós(University of Bern), Denis Larsimont(Children's Medical Research Institute), Erik G. Larsson(Berlin Institute of Health at Charité - Universitätsmedizin Berlin), Mark Lathrop, Loretta M. S. Lau(Massachusetts General Hospital), Chris Lawerenz(The University of Texas MD Anderson Cancer Center), Rita T. Lawlor(Seven Bridges Genomics (United States)), Michael S. Lawrence, Alexander J. Lazar(Canada's Michael Smith Genome Sciences Centre), Ana Mijalkovic Lazic(Yale University), Xuan Le(Boston Children's Hospital), Darlene Lee(Asan Medical Center), Dong-Hoon Lee(Harvard University), Eunjung Alice Lee(Hanyang University), Hee Jin Lee(University of California, Santa Cruz), Jake June-Koo Lee(Institute of Biomedical Sciences, Academia Sinica), Jeong‐Yeon Lee(Wellcome Sanger Institute), Juhee Lee(ETH Zurich), Ming Ta Michael Lee(Max Planck Institute for Molecular Genetics), Henry Lee-Six(Charité - Universitätsmedizin Berlin), Kjong-Van Lehmann(The University of Queensland), Hans Lehrach(Institute of Cancer Research), Dido Lenze(Broad Institute), Conrad Leonard(McGill University and Génome Québec Innovation Centre), Daniel Leongamornlert(Biobyte Solutions (Germany)), Ignaty Leshchiner(Memorial Sloan Kettering Cancer Center), Louis Létourneau(Baylor College of Medicine), Ivica Letunić(Washington University in St. Louis), Douglas A. Levine(BGI Group (China)), Lora Lewis(Ontario Institute for Cancer Research), Tim Ley(Canada's Michael Smith Genome Sciences Centre), David K. Chang(The University of Texas MD Anderson Cancer Center), Constance H. Li(University of Oxford), Haiyan Irene Li(Yale University), Jun Li(BGI Group (China)), Lin Li(BGI Group (China)), Shantao Li(Yale University), Siliang Li(BGI Group (China)), Xiaobo Li(Wellcome Sanger Institute), Xiaotong Li(Baylor College of Medicine), Xinyue Li(Toronto General Hospital), Yilong Li(German Cancer Research Center), Han Liang(Broad Institute), Sheng‐Ben Liang(Harvard University Press), Péter Lichter(National Institutes of Health), Pei Lin(University of Oslo), Ziao Lin(BGI Group (China)), W. Marston Linehan(Memorial Sloan Kettering Cancer Center), Ole Christian Lingjærde(Princess Margaret Cancer Centre), Dongbing Liu(Peking University), Eric Minwei Liu(Leidos (United States)), Fei-Fei Fei Liu(BGI Group (China)), Fenglin Liu(Ontario Institute for Cancer Research), Jia Liu(Broad Institute), Xingmin Liu(Royal Marsden NHS Foundation Trust), Julie Livingstone(Yale University), Dimitri Livitz(Leipzig University), Naomi Livni(The University of Sydney), Lucas Lochovsky(Consorci Institut D'Investigacions Biomediques August Pi I Sunyer), Markus Loeffler(Yale University), Georgina V. Long(Massachusetts General Hospital), Armando López‐Guillermo(University College London), Shaoke Lou(The University of Texas MD Anderson Cancer Center), David N. Louis(Queen Mary University of London), Laurence Lovat(Beijing Hospital), Yiling Lu, Yong‐Jie Lu(Ontario Institute for Cancer Research), Youyong Lu(Ontario Institute for Cancer Research), Claudio Luchini(University College London), Ilinca M. Lungu(University of Cambridge), Xuemei Luo(Institute for Systems Biology), Hayley J. Luxton(Universität Ulm), Andy G. Lynch(Universidad de Oviedo), Lisa Lype(Hong Kong University of Science and Technology), Cristina López(Canada's Michael Smith Genome Sciences Centre), Carlos López-Otı́n(Institut Bergonié), Z. Eric(University of Cambridge), Yussanne Ma(University of Cambridge), Gaëtan MacGrogan(Aarhus University Hospital), Shona MacRae(RIKEN Center for Integrative Medical Sciences), Geoff Macintyre, Tobias Madsen(University of Southern California), Kazuhiro Maejima(National Institute of Biomedical Genomics), Andrea Mafficini(National Institute of Biomedical Genomics), Dennis T. Maglinte(University of Pavia), Arindam Maitra(Simon Fraser University), Partha P. Majumder, Luca Malcovati(The University of Sydney), Salem Malikić(Orthopädische Praxis), Giuseppe Malleo(Ghent University), Graham J. Mann, Luisa Mantovani‐Löffler(James S. McDonnell Foundation), Kathleen Marchal(Oregon Health & Science University), Giovanni Marchegiani(University of California, Santa Cruz), Elaine R. Mardis(University of Cambridge), Adam A. Margolin(Max Delbrück Center), Maximillian G. Marin(Duke University), Florian Markowetz(Centre for Genomic Regulation), Julia Markowski(Canada's Michael Smith Genome Sciences Centre), Jeffrey R. Marks(University of Oxford), Tomàs Marquès‐Bonet(Cancer Genomics Centre), Marco A. Marra(University of Glasgow), Luke Marsden(Institució Catalana de Recerca i Estudis Avançats), John W.M. Martens(Wellcome Sanger Institute), Sancha Martin(Cornell University), José I. Martín‐Subero(Massachusetts General Hospital), Iñigo Martincorena(James S. McDonnell Foundation), Alexander Martinez‐Fundichely(University of Cambridge), Yosef E. Maruvka(University of California, Santa Cruz), R. Jay Mashl(Institute of Cancer Research), Charlie E. Massie(Royal Marsden NHS Foundation Trust), Thomas J. Matthew(Oxford Nanopore Technologies (United Kingdom)), Lucy Matthews(Canada's Michael Smith Genome Sciences Centre), Erik Mayer(Ontario Institute for Cancer Research), Simon Mayes(University of California, San Francisco), Michael Mayo(Wellcome Sanger Institute), Faridah Mbabaali(Yale University), Karen McCune(James S. McDonnell Foundation), Ultan McDermott(Ontario Institute for Cancer Research), Patrick D. McGillivray(Duke-NUS Medical School), Michael D. McLellan(Mount Sinai Hospital), John D. McPherson(Broad Institute), John R. McPherson(Princess Margaret Cancer Centre), Treasa A. McPherson(University of North Carolina at Chapel Hill), Samuel R. Meier(Wellcome Sanger Institute), Alice Meng, Shaowu Meng(Institute of Cancer Research), Andrew Menzies(Broad Institute), Neil D. Merrett(Yale University), Sue Merson(University of North Carolina at Chapel Hill), Matthew Meyerson(Ontario Institute for Cancer Research), William Meyerson(Seven Bridges Genomics (United States)), Piotr A. Mieczkowski(Henry Ford Hospital), George L. Mihaiescu, Sanja Mijalković(The University of Melbourne), Tom Mikkelsen(James S. McDonnell Foundation), Michèle Milella(Garvan Institute of Medical Research), Linda Mileshkin(Ontario Institute for Cancer Research), Christopher A. Miller(Oregon Health & Science University), David K. Miller(Barcelona Supercomputing Center), Jessica K. Miller(Universität Hamburg), Gordon B. Mills, Ana Milovanovic(The University of Melbourne), Sarah Minner(National Institutes of Health), Marco Miotto(The University of Melbourne), Gisela Mir Arnau(University of Cambridge), Lisa Mirabello, Thomas J. Mitchell, Thomas J. Mitchell(Kyushu University), Satoru Miyano(Heidelberg Academy of Sciences and Humanities), Naoki Miyoshi(Princess Margaret Cancer Centre), Shinichi Mizuno(Canada's Michael Smith Genome Sciences Centre), Fruzsina Molnár‐Gábor(Wellcome Sanger Institute), Malcolm J. Moore(University of Toronto), Richard A. Moore(Roswell Park Comprehensive Cancer Center), Sandro Morganella(University of North Carolina at Chapel Hill), Quaid Morris(Mayo Clinic in Arizona), Quaid Morris(Universitat Pompeu Fabra), Lisle E. Mose(Universitat Pompeu Fabra), Catherine D. Moser(Canada's Michael Smith Genome Sciences Centre), Ferran Muiños(Canada's Michael Smith Genome Sciences Centre), Loris Mularoni(University of Glasgow), Andrew J. Mungall(University of Helsinki), Karen Mungall(Washington University in St. Louis), Elizabeth A. Musgrove(University of Tübingen), Ville Mustonen(Baylor College of Medicine), David G. Mutch(European Bioinformatics Institute), Francesc Muyas(Penrose-St. Francis Health Services), Donna M. Muzny(University of Bergen), Alfonso Muñoz(University Hospital Ulm), Jerome Myers(The University of Tokyo), Ola Myklebost(Garvan Institute of Medical Research), Peter Möller(Ontario Institute for Cancer Research), Genta Nagae, Adnan Nagrial(RIKEN Center for Integrative Medical Sciences), Hardeep K. Nahal-Bose, Hitoshi Nakagama(Hokkaido University), Hidewaki Nakagawa(RIKEN Center for Integrative Medical Sciences), Hiromi Nakamura(Genome Institute of Singapore), Toru Nakamura(Wellcome Sanger Institute), Kaoru Nakano(Seven Bridges Genomics (United States)), Tannistha Nandi(Institució Catalana de Recerca i Estudis Avançats), Jyoti Nangalia(Yale University), Mia Nastic(University of Cambridge), Arcadi Navarro(German Cancer Aid), Fábio C. P. Navarro(The University of Queensland), David E. Neal(European Bioinformatics Institute), Gerd Nettekoven(University of California, Santa Cruz), Felicity Newell(Duke-NUS Medical School), Steven Newhouse(Chinese University of Hong Kong), Yulia Newton(Wellcome Sanger Institute), Alvin Wei Tian Ng(Royal Marsden NHS Foundation Trust), Anthony Ng(Xijing Hospital), Jonathan Nicholson(Massachusetts General Hospital), David Nicol(Aarhus University Hospital), Yongzhan Nie(University of Cambridge), G. Petur Nielsen(Broad Institute), Morten Muhlig Nielsen(The University of Queensland), Serena Nik‐Zainal(St. Jude Children's Research Hospital), Michael S. Noble(Ontario Institute for Cancer Research), Kátia Nones(University of California, Santa Cruz), Paul A. Northcott(University of Chicago), Faiyaz Notta(University of Cambridge), Brian D. O’Connor(Wellcome Sanger Institute), Peter H. O’Donnell(Mayo Clinic in Arizona), Maria O’Donovan(Cambridge University Hospitals NHS Foundation Trust), Sarah O’Meara(European Bioinformatics Institute), Brian Patrick O’Neill(Memorial Sloan Kettering Cancer Center), J. Robert O’Neill(Carleton College), David Ocaña(Royal Marsden NHS Foundation Trust), Angelica Ochoa(Hiroshima University), Layla Oesper, Christopher Ogden(University of California San Diego), Hideki Ohdan(The University of Melbourne), Kazuhiro Ohi(University of Alabama at Birmingham), Lucila Ohno‐Machado(Keio University), Karin A. Oien, Akinyemi I. Ojesina(Sage Bionetworks), Hidenori Ojima(National Cancer Centre Singapore), Takuji Okusaka(Universitat Pompeu Fabra), Larsson Omberg(Robert Bosch Hospital), Choon Kiat Ong(University of Toronto), Stephan Ossowski(Ontario Institute for Cancer Research), German Ott(Ontario Institute for Cancer Research), B. F. Francis Ouellette, Christine P’ng(The University of Melbourne), Marta Paczkowska(Garvan Institute of Medical Research), Salvatore Paiella(BGI Group (China)), Chawalit Pairojkul(Wellcome Sanger Institute), Marina Pajic(European Bioinformatics Institute), Qiang Pan‐Hammarström(German Cancer Research Center), Elli Papaemmanuil(Hallym University), Irene Papatheodorou(National Cancer Center), Nagarajan Paramasivam(Samsung (South Korea)), Ji Wan Park(Sangmyung University), Joong-Won Park(Harvard University), Keunchil Park(University of North Carolina at Chapel Hill), Kiejung Park(Nottingham University Hospitals NHS Trust), Peter J. Park(NYU Langone Health), Peter J. Park(Ontario Institute for Cancer Research), Simon L. Parsons(Memorial Sloan Kettering Cancer Center), Harvey I. Pass(The University of Queensland), Danielle Pasternack(Institut National du Cancer), Alessandro Pastore, Ann‐Marie Patch(The University of Queensland), Iris Pauporté(Broad Institute), Antonio Pea(Aarhus University Hospital), John V. Pearson, Chandra Sekhar Pedamallu(University of Cologne), Jakob Skou Pedersen(Cleveland Clinic), Paolo Pederzoli(University of North Carolina at Chapel Hill), Martin Peifer(University of California, San Francisco), Nathan A. Pennell(Mayo Clinic in Florida), Charles M. Perou(Oregon Health & Science University), Marc D. Perry(Christiana Care Health System), Gloria M. Petersen(European Bioinformatics Institute), Myron Peto(Hopp Children's Cancer Center Heidelberg), Nicholas Petrelli(McGill University and Génome Québec Innovation Centre), Robert Petryszak(Universitat Pompeu Fabra), Stefan M. Pfister(Children's Medical Research Institute), Mark Phillips(SRA International (United States)), Oriol Pich(London Cancer), Hilda A. Pickett(Guy's Hospital), Todd Pihl(Garvan Institute of Medical Research), Nischalan Pillay(Macquarie University), Sarah E. Pinder(European Molecular Biology Laboratory), Mark Pinese(Inserm), Andreia V. Pinho(Spanish National Cancer Research Centre), Esa Pitkänen(German Cancer Aid), Xavier Pivot(German Cancer Research Center), Elena Piñeiro-Yáñez(Broad Institute), Laura Planko(Spanish National Cancer Research Centre), Christoph Plass(Institutul Clinic Fundeni), Paz Polak, Tirso Pons(Universitat Pompeu Fabra), Irinel Popescu(Royal Surrey County Hospital), Olga Potapova(German Cancer Research Center), Aparna Prasad(QIMR Berghofer Medical Research Institute), Shaun R. Preston(Ontario Institute for Cancer Research), Manuel Prinz(Cambridge University Hospitals NHS Foundation Trust), Antonia L. Pritchard(Universidad de Oviedo), Stephenie D. Prokopec(University of North Carolina at Chapel Hill), Elena Provenzano(Barcelona Supercomputing Center), Xosé S. Puente(Ghent University), Sonia Puig(The University of Sydney), Montserrat Puiggròs(Ninewells Hospital), Sergio Pulido-Tamayo(The University of Queensland), Gulietta M. Pupo(Centre for Genomic Regulation), Colin A. Purdie(Medical College of Wisconsin), Michael C. Quinn(German Cancer Research Center), Raquel Rabionet(Seven Bridges Genomics (United States)), Janet S. Rader(European Molecular Biology Laboratory), Bernhard Radlwimmer(Wellcome Sanger Institute), Petar Radovic(Wellcome Sanger Institute), Benjamin Raeder(Wellcome Sanger Institute), Keiran Raine(Emory University), Manasa Ramakrishna(Princeton University), Kamna Ramakrishnan(Vanderbilt University), Suresh Ramalingam(European Molecular Biology Laboratory), Benjamin J. Raphael(Heinrich Heine University Düsseldorf), W. Kimryn Rathmell(Ontario Institute for Cancer Research), Tobias Rausch(Memorial Sloan Kettering Cancer Center), Guido Reifenberger(Memorial Sloan Kettering Cancer Center), Jüri Reimand(Institute for Research in Biomedicine), Jorge S. Reis‐Filho(Princeton University), Victor E. Reuter(Institute for Systems Biology), Iker Reyes-Salazar(Harvard University), Matthew A. Reyna(McGill University), Sheila M. Reynolds(Dana-Farber Cancer Institute), Esther Rheinbay(Christian-Albrechts-Universität zu Kiel), Yasser Riazalhosseini(The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute), Andrea L. Richardson(Lund University), Julia Richter(Yokohama City University), Matthew D. Ringel(German Cancer Research Center), Markus Ringnér(University of North Carolina at Chapel Hill), Yasushi Rino(Mayo Clinic in Arizona), Karsten Rippe(Wellcome Sanger Institute), Jeffrey Roach(Washington State University), Lewis R. Roberts(Canada's Michael Smith Genome Sciences Centre), Nicola D. Roberts(The University of Queensland), Steven A. Roberts(Barcelona Supercomputing Center), A. Gordon Robertson(Universidade de Santiago de Compostela), Alan J. Robertson(Cancer Genomics Centre), Javier Bartolomé Rodriguez(University of Toronto), Bernardo Rodríguez–Martín(Universitätsklinikum Gießen und Marburg), F. Germán Rodríguez-González(National Cancer Centre Japan), Michael H. A. Roehrl(Institut de Recherche en Cancérologie de Montpellier), Marius Rohde(Garvan Institute of Medical Research), Hirofumi Rokutan(Norfolk and Norwich University Hospital), Gilles Romieu(Broad Institute), Ilse Rooman(Broad Institute), Tom Roques, Daniel Rosebrock(University of Würzburg), Mara Rosenberg(Royal Marsden NHS Foundation Trust), Philip Rosenstiel(Barcelona Supercomputing Center), Andreas Rosenwald(Duke-NUS Medical School), Edward Rowe(University of Toronto), Romina Royo(University of Bern), Steve Rozen(Vall d'Hebron Institut de Recerca), Yulia Rubanova(European Molecular Biology Laboratory), Mark A. Rubin, Carlota Rubio-Pérez, Vasilisa A. Rudneva(SIB Swiss Institute of Bioinformatics), Borislav C. Rusev(Tata Institute of Fundamental Research), Andrea Ruzzenente(Ontario Institute for Cancer Research), Gunnar Rätsch(Canada's Michael Smith Genome Sciences Centre), Radhakrishnan Sabarinathan(Simon Fraser University), Veronica Y. Sabelnykova(National Institute of Environmental Health Sciences), Sara Sadeghi(National Cancer Centre Japan), S. Cenk Sahinalp(Broad Institute), Natalie Saini(Ontario Institute for Cancer Research), Mihoko Saito-Adachi(GZA Ziekenhuizen Campus Sint-Augustinus), Gordon Saksena(Yale University), Adriana Salcedo(Broad Institute), Roberto Salgado(Analytical Biological Services (United States)), Leonidas Salichos, Richard Sallari(Ontario Institute for Cancer Research), Charles Saller(The University of Sydney), Roberto Salvia(Memorial Sloan Kettering Cancer Center), Michelle Sam(Harvard University), Jaswinder S. Samra(University of North Carolina at Chapel Hill), Francisco Sánchez-Vega(Tata Memorial Hospital), Chris Sander(Simon Fraser University), Grant Sanders(RIKEN Center for Integrative Medical Sciences), Rajiv Sarin(University of Oslo), Iman Sarrafi(Universität Hamburg), Aya Sasaki-Oku(The University of Sydney), Torill Sauer, Guido Sauter(Hunter Water), Robyn P.M. Saw, Maria Scardoni(Centre international de recherche sur le cancer), Christopher J. Scarlett(German Cancer Research Center), Aldo Scarpa(Canada's Michael Smith Genome Sciences Centre), Ghislaine Scélo, Dirk Schadendorf(German Cancer Research Center), Jacqueline E. Schein(Charité - Universitätsmedizin Berlin), Markus B. Schilhabel(James S. McDonnell Foundation), Matthias Schlesner(The University of Sydney), Thorsten Schlomm(Christian-Albrechts-Universität zu Kiel), Heather K. Schmidt(Memorial Sloan Kettering Cancer Center), Sarah‐Jane Schramm(Dana-Farber Cancer Institute), Stefan Schreiber(German Cancer Society), Nikolaus Schultz(The University of Sydney), Steven E. Schumacher(Cancer Research Horizons), Roland F. Schwarz(Beth Israel Deaconess Medical Center), Richard A. Scolyer(University of Pittsburgh), David Scott(Massachusetts Eye and Ear Infirmary), Ralph Scully(Mount Sinai Hospital), Raja R. Seethala(Institute of Genetics and Cancer), Ayellet V. Segrè(Memorial Sloan Kettering Cancer Center), Iris Selander(NorthShore University HealthSystem), Colin A. Semple, Yasin Şenbabaoğlu(University of Toronto), Subhajit Sengupta(Massachusetts General Hospital), Elisabetta Sereni(The University of Melbourne), Stefano Serra(Cambridge University Hospitals NHS Foundation Trust), Dennis C. Sgroi(Toronto General Hospital), Mark Shackleton(Bioplatforms Australia), Nimish Shah(The University of Sydney), Sagedeh Shahabi(Broad Institute), Catherine A. Shang(International Genomics Consortium), Ping Shang(Harvard University), Ofer Shapira(Van Andel Institute), Troy Shelton(Wellcome Sanger Institute), Ciyue Shen(University of Toronto), Hui Shen(University of North Carolina at Chapel Hill), Rebecca Shepherd(Ontario Institute for Cancer Research), Ruian Shi, Yan Shi(Dana-Farber Cancer Institute), Yu-Jia Shiah, Tatsuhiro Shibata(Japan Agency for Medical Research and Development), Juliann Shih(Korea University), Eigo Shimizu, Kiyo Shimizu, Seung Jun Shin(Institute for Systems Biology), Yuichi Shiraishi(Ontario Institute for Cancer Research), Tal Shmaya(European Bioinformatics Institute), Ilya Shmulevich(Indiana University Bloomington), Solomon I. Shorser(Stanford University), Charles Short(Walter Reed National Military Medical Center), Raunak Shrestha(Ontario Institute for Cancer Research), Suyash Shringarpure(University of Copenhagen), Craig D. Shriver(Christian-Albrechts-Universität zu Kiel), Shimin Shuai(Cancer Genomics Centre), Nikos Sidiropoulos(German Cancer Research Center), Reiner Siebert(Harvard University), Anieta M. Sieuwerts, Lina Sieverling, Sabina Signoretti(Universität Hamburg), Katarzyna Sikora(University of North Carolina at Chapel Hill), Michele Simbolo(University of Toronto), Ronald Simon(The University of Queensland), Janae V. Simons(Memorial Sloan Kettering Cancer Center), Jared T. Simpson(Broad Institute), Peter T. Simpson(Canada's Michael Smith Genome Sciences Centre), Samuel Singer(University of North Carolina at Chapel Hill), Nasa Sinnott-Armstrong(Cancer Genomics Centre), Payal Sipahimalani(Oregon Health & Science University), Tara Skelly(University of California, San Francisco), Marcel Smid(Memorial Sloan Kettering Cancer Center), John A. Smith(National Institutes of Health), Karen Smith‐McCune(University of North Carolina at Chapel Hill), Nicholas D. Socci(National Institutes of Health), Heidi J. Sofia(The University of Texas MD Anderson Cancer Center), Matthew G. Soloway(University Hospitals Coventry and Warwickshire NHS Trust), Lei Song(University of California San Diego), Anil K. Sood(University of California, Santa Cruz), Sharmila Sothi(Radboud University Nijmegen), Christos Sotiriou(Oregon Health & Science University), Cameron M. Soulette, Paul N. Span(The University of Sydney), Paul T. Spellman(Broad Institute), Nicola Sperandio(University of Chicago), Andrew J. Spillane(Lund University), Oliver Spiro(Leipzig University), Jonathan Spring(Sankt-Antonius-Hospital Eschweiler), Johan Staaf(SIB Swiss Institute of Bioinformatics), Peter F. Stadler(Wellcome Sanger Institute), Peter Staib(University of Iceland), Stefan G. Stark(European Molecular Biology Laboratory), Lucy Stebbings(Ontario Institute for Cancer Research), Ólafur Andri Stefánsson(Ninewells Hospital), Oliver Stegle(Broad Institute), Lincoln Stein(Universität Ulm), Alasdair Stenhouse(Universitat Pompeu Fabra), Chip Stewart(Wellcome Sanger Institute), Stephan Stilgenbauer(The University of Sydney), Miranda D. Stobbe(Oregon Health & Science University), Michael R. Stratton(University of California, Santa Cruz), Jonathan R. Stretch(China National GeneBank), Adam J. Struck(BGI Group (China)), Joshua M. Stuart(The University of Texas MD Anderson Cancer Center), Henk G. Stunnenberg(Ontario Institute for Cancer Research), Hong Su(European Molecular Biology Laboratory), Xiaoping Su(Universitat Pompeu Fabra), Ren Sun(Yokohama City University), Stéphanie Sungalee(Radboud University Nijmegen), Hana Sušak(Christian-Albrechts-Universität zu Kiel), Akihiro Suzuki(German Cancer Research Center), Fred C.G.J. Sweep(Japan Agency for Medical Research and Development), Monika Szczepanowski(Canada's Michael Smith Genome Sciences Centre), Holger Sültmann(Universitat Pompeu Fabra), Takashi Yugawa(Singapore General Hospital), Angela Tam(University of North Carolina at Chapel Hill), David Tamborero(SingHealth), Benita Kiat Tee Tan, Donghui Tan, Patrick Tan(University of Helsinki), Hiroko Tanaka(The Francis Crick Institute), Hirokazu Taniguchi(National Institutes of Health), Tomas Tanskanen(Cambridge University Hospitals NHS Foundation Trust), Maxime Tarabichi(Ontario Institute for Cancer Research), Roy Tarnuzzer(The University of Tokyo), Patrick Tarpey(Columbia University Irving Medical Center), Morgan L. Taschuk(The University of Queensland), Kenji Tatsuno(Broad Institute), Simon Tavaré(Wellcome Sanger Institute), Darrin F. Taylor(SingHealth), Amaro Taylor‐Weiner(The University of Sydney), Jon W. Teague(Universidade de Santiago de Compostela), Bin Tean Teh(Ontario Institute for Cancer Research), Varsha Tembe(University of Nebraska Medical Center), Javier Temes(Canada's Michael Smith Genome Sciences Centre), Kevin Thai(Centre Léon Bérard), Sarah P. Thayer(Royal Marsden NHS Foundation Trust), Nina Thiessen(Royal Marsden NHS Foundation Trust), Gilles Thomas(Ninewells Hospital), Sarah Thomas(The University of Sydney), Alan Thompson(Mayo Clinic in Arizona), Alastair M. Thompson(The University of Melbourne), John F. Thompson(University of North Carolina at Chapel Hill), R. Houston Thompson(McGill University and Génome Québec Innovation Centre), Heather Thorne(Broad Institute), Leigh B. Thorne(Seven Bridges Genomics (United States)), Adrian Thorogood(Ontario Institute for Cancer Research), Grace Tiao(Royal National Orthopaedic Hospital), Nebojša Tijanić(Universidade de Vigo), Lee E. Timms(Istituto Tumori Bari), Roberto Tirabosco(Garvan Institute of Medical Research), Marta Tojo(German Cancer Research Center), Stefania Tommasi(Institució Catalana de Recerca i Estudis Avançats), Christopher W. Toon(University of Verona), Umut H. Toprak(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), David Torrents, Giampaolo Tortora(Maastricht University), Jörg Tost(The University of Melbourne), Yasushi Totoki(Université Claude Bernard Lyon 1), David Townend(Centre for Genomic Regulation), Nadia Traficante(University of Göttingen), Isabelle Treilleux(University Health Network), Jean-Rémi Trotta(Tokyo Medical and Dental University), Lorenz Trümper(Wellcome Sanger Institute), Ming‐Sound Tsao(University Hospitals Birmingham NHS Foundation Trust), Tatsuhiko Tsunoda(Queen's University Belfast), José M. C. Tubío(Oxford Nanopore Technologies (United Kingdom)), Olga Tucker(Dana-Farber Cancer Institute), Richard Turkington(Wakayama Medical University), Daniel J. Turner(The University of Texas MD Anderson Cancer Center), Andrew Tutt(Johns Hopkins University), Masaki Ueno(Science for Life Laboratory), Naoto T. Ueno(University of Southampton), Christopher B. Umbricht(European Bioinformatics Institute), Husen M. Umer, Tim Underwood(The University of Tokyo), Lara Urban(Tallinn University of Technology), Tomoko Urushidate(Institució Catalana de Recerca i Estudis Avançats), Tetsuo Ushiku(University of Southern California), Liis Uusküla-Reimand(University of Antwerp), Alfonso Valencia(The Francis Crick Institute), David Van Den Berg(Emory University), Steven Van Laere(University of Antwerp), Peter Van Loo(University Health Network), Erwin G. Van Meir(University of Leeds), Gert G. Van den Eynden(Norwegian University of Science and Technology), Theodorus van der Kwast(The University of Melbourne), Naveen Vasudev(University of North Carolina at Chapel Hill), Miguél Vázquez(University of Toronto), Ravikiran Vedururu(Ghent University), Umadevi Veluvolu(University of Antwerp), Shankar Vembu(University of Oxford), Lieven P. C. Verbeke, Peter Vermeulen(Barcelona Supercomputing Center), Clare Verrill, Alain Viari(Government of India), David Vicente(University of Latvia), Caterina Vicentini(The University of Sydney), K. VijayRaghavan(Barcelona Supercomputing Center), Juris Vīksna(Inserm), Ricardo E. Vilain(Tampere University Hospital), Izar Villasante(Broad Institute), Anne Vincent‐Salomon(QIMR Berghofer Medical Research Institute), Tapio Visakorpi(University of Cambridge), Douglas Voet(The University of Queensland), Paresh Vyas(The University of Queensland), Ignacio Vázquez-Garćıa(Uppsala University), Nick M. Waddell(Ontario Institute for Cancer Research), Nicola Waddell(Universität Ulm), Claes Wadelius(Broad Institute), Lina Wadi(BGI Group (China)), Rabea Wagener(James S. McDonnell Foundation), Jeremiah A. Wala(Baylor College of Medicine), Jian Wang(German Cancer Research Center), Jiayin Wang(The University of Texas MD Anderson Cancer Center), Linghua Wang(Baylor College of Medicine), Qi Wang(National Institutes of Health), Wenyi Wang(The University of Melbourne), Yumeng Wang(Max Planck Institute for Molecular Genetics), Zhining Wang(Yale University), Paul Waring(Cambridge University Hospitals NHS Foundation Trust), Hans-Jörg Warnatz(European Molecular Biology Laboratory), Jonathan Warrell(University of Oxford), Anne Y. Warren(German Cancer Research Center), Sebastian M. Waszak(Augusta University), David C. Wedge(The University of Texas MD Anderson Cancer Center), Dieter Weichenhan(European Molecular Biology Laboratory), Paul Weinberger(University of Southern California), John N. Weinstein(Wythenshawe Hospital), Joachim Weischenfeldt(Washington University in St. Louis), Daniel J. Weisenberger(Leibniz Institute for Baltic Sea Research Warnemünde), Ian Welch(Centre for Human Genetics), Michael C. Wendl(Baylor College of Medicine), Johannes Werner(University College London), Justin P. Whalley(Mayo Clinic in Arizona), David A. Wheeler(University of North Carolina at Chapel Hill), Hayley C. Whitaker(University of California San Diego), Dennis A. Wigle(The University of Sydney), Matthew D. Wilkerson(Ontario Institute for Cancer Research), Ashley Williams(Ontario Institute for Cancer Research), James S. Wilmott(Nationwide Children's Hospital), Gavin W. Wilson(Mayo Clinic in Arizona), Julie M. Wilson(University of Toronto), Richard K. Wilson(Poznan University of Medical Sciences), Boris Winterhoff(German Cancer Research Center), Jeffrey A. Wintersinger(National Cancer Centre Singapore), Maciej Wiznerowicz(James S. McDonnell Foundation), Stephan Wolf(Washington University in St. Louis), Bernice H. Wong(Electronics and Telecommunications Research Institute), Tina Wong(The University of Queensland), Winghing Wong(University of Toronto), Youngchoon Woo(Ontario Institute for Cancer Research), Scott Wood(MRC University of Glasgow Centre for Virus Research), Bradly G. Wouters(Stanford University), A. Jordan Wright(Massachusetts General Hospital), Derek Wright, Mark H. Wright(Oregon Health & Science University), Chin‐Lee Wu(Garvan Institute of Medical Research), Dai‐Ying Wu(BGI Group (China)), Guanming Wu(Duke-NUS Medical School), Jianmin Wu(Hong Kong University of Science and Technology), Kui Wu(BGI Group (China)), Yang Wu(Huazhong University of Science and Technology), Zhenggang Wu(Ontario Institute for Cancer Research), Liu Xi(New York Genome Center), Tian Xia(Peking University), Qian Xiang(BGI Group (China)), Xiao Xiao(The University of Queensland), Rui Xing(Johns Hopkins University), Heng Xiong(Hong Kong University of Science and Technology), Qinying Xu(The University of Osaka), Yanxun Xu(Heidelberg University), Hong Xue, Shinichi Yachida(Ontario Institute for Cancer Research), Sergei Yakneen(Tokyo Women's Medical University), Rui Yamaguchi(The University of Tokyo), Takafumi N. Yamaguchi(Wakayama Medical University), Masakazu Yamamoto(University of Toronto), Shogo Yamamoto(BGI Group (China)), Hiroki Yamaue(The University of Sydney), Fan Yang(National Institutes of Health), Huanming Yang(University of Chicago), Jean Yang(Hefei University of Technology), Liming Yang(University of Cologne), Lixing Yang(University of Toronto), Shanlin Yang(New York Genome Center), Tsun-Po Yang(Max Planck Institute for Molecular Genetics), Yang Yang(Wellcome Sanger Institute), Xiaotong Yao(Buck Institute for Research on Aging), Marie‐Laure Yaspo(China National GeneBank), Lucy Yates(Xi'an Jiaotong University), Christina Yau(Memorial Sloan Kettering Cancer Center), Chen Ye(Korea Advanced Institute of Science and Technology), Kai Ye(Seoul National University Hospital), Venkata Yellapantula(Ontario Institute for Cancer Research), Christopher J. Yoon(Chinese University of Hong Kong), Sung-Soo Yoon(The University of Texas MD Anderson Cancer Center), Fouad Yousif(Duke-NUS Medical School), Jun Yu(Ruijin Hospital), Kaixian Yu(University of Glasgow), Willie Yu(NorthShore University HealthSystem), Yingyan Yu(Ontario Institute for Cancer Research), Ke Yuan(Ontario Institute for Cancer Research), Yuan Yuan(Oslo University Hospital), Denis Yuen(Universidade de Santiago de Compostela), Christina K. Yung(German Cancer Research Center), Olga Zaikova(National Institutes of Health), Jorge Zamora(National Center for Tumor Diseases), Marc Zapatka(Epworth Hospital), Jean C. Zenklusen(Harvard University), Thorsten Zenz(Peking University), Nikolajs Zeps(Broad Institute), Cheng‐Zhong Zhang(Second Military Medical University), Fan Zhang(Memorial Sloan Kettering Cancer Center), Hailei Zhang(National Institutes of Health), Hongwei Zhang(Yale University), Hongxin Zhang(Ontario Institute for Cancer Research), Jiashan Zhang(BGI Group (China)), Jing Zhang(The University of Texas Health Science Center at Houston), Junjun Zhang(The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute), Xiuqing Zhang(Peking University), Xuanping Zhang(University of Houston), Yan Zhang(Peking University), Zemin Zhang(Peking University), Zhongming Zhao(Van Andel Institute), Liangtao Zheng(BGI Group (China)), Xiuqing Zheng(National Institutes of Health), Wanding Zhou(The University of Texas MD Anderson Cancer Center), Yong Zhou(University of California, Santa Cruz), Bin Zhu(BGI Group (China)), Hongtu Zhu(Northwestern University), Jingchun Zhu(Wellcome Sanger Institute), Shida Zhu(The University of Sydney), Lihua Zou(Royal Marsden NHS Foundation Trust), Xueqing Zou(Erasmus MC), Anna DeFazio(The University of Melbourne), Nicholas van As(The Netherlands Cancer Institute), Carolien H. M. van Deurzen(SIB Swiss Institute of Bioinformatics), Marc J. van de Vijver, L. van’t Veer, Christian von Mering
Cited by 190Open Access
Abstract
Long non-coding RNAs (lncRNAs) are a growing focus of cancer genomics studies, creating the need for a resource of lncRNAs with validated cancer roles. Furthermore, it remains debated whether mutated lncRNAs can drive tumorigenesis, and whether such functions could be conserved during evolution. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we introduce the Cancer LncRNA Census (CLC), a compilation of 122 GENCODE lncRNAs with causal roles in cancer phenotypes. In contrast to existing databases, CLC requires strong functional or genetic evidence. CLC genes are enriched amongst driver genes predicted from somatic mutations, and display characteristic genomic features. Strikingly, CLC genes are enriched for driver mutations from unbiased, genome-wide transposon-mutagenesis screens in mice. We identified 10 tumour-causing mutations in orthologues of 8 lncRNAs, including LINC-PINT and NEAT1, but not MALAT1. Thus CLC represents a dataset of high-confidence cancer lncRNAs. Mutagenesis maps are a novel means for identifying deeply-conserved roles of lncRNAs in tumorigenesis.
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