High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
Yiqun Zhang(Baylor College of Medicine), Fengju Chen(Baylor College of Medicine), Nuno A. Fonseca(European Bioinformatics Institute), Yao He(Peking University), Masashi Fujita(RIKEN Center for Integrative Medical Sciences), Hidewaki Nakagawa(RIKEN Center for Integrative Medical Sciences), Zemin Zhang(Peking University), Alvis Brāzma(European Bioinformatics Institute), PCAWG Transcriptome Working Group(The University of Texas MD Anderson Cancer Center), Samirkumar B. Amin(Ontario Institute for Cancer Research), Philip Awadalla(Cancer Research UK Scotland Institute), Peter J. Bailey(European Bioinformatics Institute), Alvis Brazma(Broad Institute), Angela N. Brooks(European Bioinformatics Institute), Claudia Calabrese(Ontario Institute for Cancer Research), Aurélien Chateigner(University of Cambridge), Isidro Cortés‐Ciriano(University of California, Santa Cruz), Brian Craft(Broad Institute), David Craft(The University of Texas MD Anderson Cancer Center), Chad J. Creighton(SIB Swiss Institute of Bioinformatics), Natalie R. Davidson(National University of Singapore), Deniz Demircioğlu(European Molecular Biology Laboratory), Serap Erkek(Universidade do Porto), Nuno A. Fonseca(European Bioinformatics Institute), Milana Frenkel‐Morgenstern(University of California, Santa Cruz), Mary J. Goldman(European Bioinformatics Institute), Liliana Greger(Genome Institute of Singapore), Jonathan Göke(Peking University), Yao He(University of North Carolina at Chapel Hill), Katherine A. Hoadley(BGI Group (China)), Yong Hou(Max Delbrück Center), Matthew R. Huska(SIB Swiss Institute of Bioinformatics), André Kahles(Cornell University), Ekta Khurana(University College London), Helena Kilpinen(European Molecular Biology Laboratory), Jan O. Korbel(Ontario Institute for Cancer Research), Fabien C. Lamaze(Memorial Sloan Kettering Cancer Center), Kjong-Van Lehmann(BGI Group (China)), David K. Chang(BGI Group (China)), Siliang Li(BGI Group (China)), Xiaobo Li(BGI Group (China)), Xinyue Li(BGI Group (China)), Dongbing Liu(Peking University), Fenglin Liu(BGI Group (China)), Xingmin Liu(University of California, Santa Cruz), Maximillian G. Marin(Max Delbrück Center), Julia Markowski(Broad Institute), Matthew Meyerson(Genome Institute of Singapore), Tannistha Nandi(Aarhus University Hospital), Morten Muhlig Nielsen(University of Alabama at Birmingham), Akinyemi I. Ojesina(Ontario Institute for Cancer Research), B. F. Francis Ouellette(BGI Group (China)), Qiang Pan-Hammarström(Harvard University), Peter J. Park(Broad Institute), Chandra Sekhar Pedamallu(Aarhus University), Jakob Skou Pedersen(Ontario Institute for Cancer Research), Marc D. Perry(Memorial Sloan Kettering Cancer Center), Gunnar Rätsch(European Bioinformatics Institute), Roland F. Schwarz(The University of Tokyo), Yuichi Shiraishi(Universität Ulm), Reiner Siebert(University of California, Santa Cruz), Cameron M. Soulette(SIB Swiss Institute of Bioinformatics), Stefan G. Stark(European Bioinformatics Institute), Oliver Stegle(BGI Group (China)), Hong Su(Duke-NUS Medical School), Patrick Tan(SingHealth), Bin Tean Teh(European Bioinformatics Institute), Lara Urban(BGI Group (China)), Jian Wang(European Molecular Biology Laboratory), Sebastian M. Waszak(BGI Group (China)), Kui Wu(Ontario Institute for Cancer Research), Qian Xiang(BGI Group (China)), Heng Xiong(European Molecular Biology Laboratory), Sergei Yakneen(BGI Group (China)), Huanming Yang(BGI Group (China)), Chen Ye(Ontario Institute for Cancer Research), Christina K. Yung(Peking University), Fan Zhang(Ontario Institute for Cancer Research), Junjun Zhang(BGI Group (China)), Xiuqing Zhang(Peking University), Zemin Zhang(Peking University), Liangtao Zheng(University of California, Santa Cruz), Jingchun Zhu(BGI Group (China)), Shida Zhu(The University of Texas MD Anderson Cancer Center), PCAWG Structural Variation Working Group(Universidade de Santiago de Compostela), Kadir C. Akdemir(University of Cambridge), Eva G. Álvarez(Broad Institute), Adrian Baez‐Ortega(University of California, Los Angeles), Rameen Beroukhim(The University of Melbourne), Paul C. Boutros(German Cancer Research Center), David D.L. Bowtell(Johns Hopkins University), Benedikt Brors(University of Cambridge), Kathleen H. Burns(University of Ottawa), Peter J. Campbell(The University of Texas MD Anderson Cancer Center), Kin Chan(Harvard University), Ken Chen(Universitat de Vic - Universitat Central de Catalunya), Isidro Cortés‐Ciriano(Broad Institute), Ana Dueso-Barroso(University of Cambridge), Andrew Dunford, Paul A. Edwards(Peter MacCallum Cancer Centre), Xavier Estivill(German Cancer Research Center), Dariush Etemadmoghadam(The University of Queensland), Lars Feuerbach(Bar-Ilan University), J. Lynn Fink(The University of Melbourne), Milana Frenkel‐Morgenstern(Princeton University), Dale W. Garsed(National Institute of Environmental Health Sciences), Mark Gerstein(University of California, Santa Cruz), Dmitry A. Gordenin(Brandeis University), David Haan(Massachusetts General Hospital), James E. Haber(German Cancer Research Center), Julian M. Hess(Cornell University), Barbara Hutter(German Cancer Research Center), Marcin Imieliński(Wellcome Sanger Institute), David Jones(Skolkovo Institute of Science and Technology), Young Seok Ju(National Institute of Environmental Health Sciences), Marat D. Kazanov(Seoul National University Hospital), Leszek J. Klimczak(European Molecular Biology Laboratory), Youngil Koh(Broad Institute), Jan O. Korbel(Boston Children's Hospital), Kiran Kumar(Harvard University), Eunjung Alice Lee(Wellcome Sanger Institute), Jake June-Koo Lee(University of Cambridge), Yilong Li(University of Cambridge), Andy G. Lynch(University of Cambridge), Geoff Macintyre(Wellcome Sanger Institute), Florian Markowetz(Cornell University), Iñigo Martincorena(The University of Melbourne), Alexander Martinez-Fundichely(The University of Tokyo), Matthew Meyerson(RIKEN Center for Integrative Medical Sciences), Satoru Miyano(Yale University), Hidewaki Nakagawa(Universitat Pompeu Fabra), Fábio C. P. Navarro(Harvard University), Stephan Ossowski(The University of Queensland), Peter J. Park(Barcelona Supercomputing Center), John V. Pearson(German Cancer Research Center), Montserrat Puiggròs(Wellcome Sanger Institute), Karsten Rippe(Washington State University), Nicola D. Roberts(Universidade de Santiago de Compostela), Steven A. Roberts(Dana-Farber Cancer Institute), Bernardo Rodriguez-Martin(Beth Israel Deaconess Medical Center), Steven E. Schumacher(The University of Melbourne), Ralph Scully(University of Copenhagen), Mark Shackleton(German Cancer Research Center), Nikos Sidiropoulos(Broad Institute), Lina Sieverling(Institució Catalana de Recerca i Estudis Avançats), Chip Stewart(Universidade de Santiago de Compostela), David Torrents(Barcelona Supercomputing Center), José M. C. Tubío(The University of Queensland), Izar Villasante(Broad Institute), Nicola Waddell(Charité - Universitätsmedizin Berlin), Jeremiah A. Wala(University of Chicago), Joachim Weischenfeldt(New York Genome Center), Lixing Yang(Seoul National University Hospital), Xiaotong Yao(Universidade de Santiago de Compostela), Sung-Soo Yoon(Broad Institute), Jorge Zamora(The University of Texas MD Anderson Cancer Center), Cheng‐Zhong Zhang(University of Helsinki), Chad J. Creighton(The University of Texas MD Anderson Cancer Center), Lauri A. Aaltonen(Memorial Sloan Kettering Cancer Center), Federico Abascal(The University of Tokyo), Adam Abeshouse(Wellcome Sanger Institute), Hiroyuki Aburatani(University of Chicago), David J. Adams(Keimyung University Dongsan Medical Center), Nishant Agrawal(Gachon University Gil Medical Center), Keun Soo Ahn(Hiroshima University), Sung‐Min Ahn(The University of Texas MD Anderson Cancer Center), Hiroshi Aikata(The University of Texas MD Anderson Cancer Center), Rehan Akbani(Memorial Sloan Kettering Cancer Center), Kadir C. Akdemir(King Faisal Specialist Hospital & Research Centre), Hikmat Al‐Ahmadie(Spanish National Cancer Research Centre), Sultan T. Al‐Sedairy(Universität Hamburg), Fátima Al‐Shahrour(Ontario Institute for Cancer Research), Malik Alawi(The University of Texas MD Anderson Cancer Center), Monique Albert(Wellcome Sanger Institute), Kenneth Aldape(Canada's Michael Smith Genome Sciences Centre), Ludmil B. Alexandrov(The University of Melbourne), Adrian Ally(Universidade de Santiago de Compostela), Kathryn Alsop(Royal National Orthopaedic Hospital), Eva G. Álvarez(The University of Texas MD Anderson Cancer Center), Fernanda Amary(Ontario Institute for Cancer Research), Samirkumar B. Amin(Universität Ulm), Brice Aminou(The University of Queensland), Ole Ammerpohl(Salford Royal NHS Foundation Trust), Matthew J. Anderson, Yeng Ang(Oregon Health & Science University), Davide Antonello, Pavana Anur(James S. McDonnell Foundation), Samuel Aparício, Elizabeth L. Appelbaum, Yasuhito Arai(Hiroshima University), Axel Aretz(Tokyo Women's Medical University), Koji Arihiro(Memorial Sloan Kettering Cancer Center), Shun‐ichi Ariizumi(Los Alamos National Laboratory), Joshua Armenia(University Health Network), Laurent Arnould(German Cancer Research Center), L. Sylvia(Ontario Institute for Cancer Research), Yassen Assenov(Universität Ulm), Gurnit Atwal(University of North Carolina at Chapel Hill), Sietse Aukema(Oslo University Hospital), J. Todd Auman(Ontario Institute for Cancer Research), Miriam R. R. Aure(Consorci Institut D'Investigacions Biomediques August Pi I Sunyer), Philip Awadalla(University of Toronto), Marta Aymerich(University of Cambridge), Gary D. Bader(James S. McDonnell Foundation), Adrian Baez‐Ortega(Cancer Research UK Scotland Institute), Matthew H. Bailey(Canada's Michael Smith Genome Sciences Centre), Peter J. Bailey(University of North Carolina at Chapel Hill), Miruna Balasundaram(Broad Institute), Saianand Balu(University of Leeds), Pratiti Bandopadhayay, Rosamonde E. Banks(The University of Queensland), Stefano Barbi(Ontario Institute for Cancer Research), Andrew P. Barbour(University Hospitals of Cleveland), Jonathan Barenboim(Gloucestershire Royal Hospital), Jill S. Barnholtz‐Sloan(European Bioinformatics Institute), Hugh Barr(Ontario Institute for Cancer Research), Elisabet Barrera(Barcelona Supercomputing Center), John G. Bartlett, Javier Bartolomé(University of Calgary), Claudio Bassi(Oslo University Hospital), Oliver F. Bathe(Ontario Institute for Cancer Research), Daniel Baumhoer(Johns Hopkins University), Prashant Bavi(European Bioinformatics Institute), Stephen B. Baylin(Royal Stoke University Hospital), Wojciech Bażant(Ontario Institute for Cancer Research), Duncan Beardsmore(Wellcome Sanger Institute), Tim Beck(La Trobe University), Sam Behjati(Chinese Academy of Sciences), Andreas Behren(Genome Canada), Beifang Niu(Universitat Pompeu Fabra), Cindy Bell(Buck Institute for Research on Aging), Sergi Beltrán(Duke Medical Center), Christopher C. Benz(Medizinische Hochschule Hannover), Andrew Berchuck(University of California San Diego), Anke K. Bergmann(Cedars-Sinai Medical Center), Erik N. Bergstrom(Queen Mary University of London), Benjamin P. Berman(Leipzig University), Daniel M. Berney(Broad Institute), Stephan H. Bernhart(University of Southern California), Rameen Beroukhim, Mario Berríos(Aarhus University), Samantha Bersani(Secretaria de Salud), Johanna Bertl(Ontario Institute for Cancer Research), Miguel Betancourt(Wellcome Sanger Institute), Vinayak Bhandari(University of Glasgow), Shriram G. Bhosle(German Cancer Research Center), Andrew V. Biankin(Duke Medical Center), Matthias Bieg(Leipzig University), Darell D. Bigner(European Bioinformatics Institute), Hans Binder(Massachusetts General Hospital), Ewan Birney(National Institute of Biomedical Genomics), Michael Birrer(Oslo University Hospital), Nidhan K. Biswas(University of North Carolina at Chapel Hill), Bodil Bjerkehagen(University of North Carolina at Chapel Hill), Tom Bodenheimer, Lori Boice(Institute of Cancer Research), Giada Bonizzato(Duke-NUS Medical School), Johann S. de Bono(University of Southern California), Arnoud Boot(Lund University), Moiz S. Bootwalla(Heinrich Heine University Düsseldorf), Åke Borg(RIKEN Center for Integrative Medical Sciences), Arndt Borkhardt(Ontario Institute for Cancer Research), Keith A. Boroevich(Friedrich-Ebert-Krankenhaus), Ivan Borozan(Yale University), Christoph W. Borst(Universitat Pompeu Fabra), Marcus Bosenberg(University of Oxford), Mattia Bosio(McGill University), Jacqueline Boultwood(University of California, Los Angeles), Guillaume Bourque(Tampere University Hospital), Paul C. Boutros(Wellcome Sanger Institute), G. Steven Bova(Canada's Michael Smith Genome Sciences Centre), David Bowen(The University of Melbourne), Reanne Bowlby(Centre Léon Bérard), David D.L. Bowtell(European Bioinformatics Institute), Sandrine Boyault(Fox Chase Cancer Center), Rich Boyce(European Bioinformatics Institute), Jeffrey M. Boyd(Centre international de recherche sur le cancer), Alvis Brazma(University of East Anglia), Paul Brennan(Radboud University Nijmegen), Daniel S. Brewer(University of Toronto), Arie B. Brinkman(The University of Texas MD Anderson Cancer Center), Robert G. Bristow(Brigham and Women's Hospital), Russell R. Broaddus(Johns Hopkins University), Jane E. Brock(The Netherlands Cancer Institute), Malcolm V. Brock(Broad Institute), Annegien Broeks(Canada's Michael Smith Genome Sciences Centre), Angela N. Brooks(National Center for Tumor Diseases), Denise Brooks(University of Copenhagen), Benedikt Brors(The University of Queensland), Søren Brunak(Universidade de Santiago de Compostela), Timothy J. C. Bruxner(Oregon Health & Science University), Alicia L. Bruzos(German Cancer Research Center), Alex Buchanan(Bundesministerium für Forschung, Technologie und Raumfahrt), Ivo Buchhalter(Broad Institute), Christiane Buchholz(The University of Sydney), Susan Bullman(University Hospital Münster), Hazel Burke(Johns Hopkins University), Birgit Burkhardt(Broad Institute), Kathleen H. Burns(Stanford University), John Busanovich(Wellcome Sanger Institute), Carlos D. Bustamante(University of California, San Francisco), Adam P. Butler(Ontario Institute for Cancer Research), Atul J. Butte(Oslo University Hospital), Niall J. Byrne(National Institutes of Health), Anne‐Lise Børresen‐Dale(European Bioinformatics Institute), Rory Johnson(Royal Marsden NHS Foundation Trust), Andy Cafferkey(European Molecular Biology Laboratory), Declan Cahill(University of Cambridge), Claudia Calabrese(Institut Gustave Roussy), Carlos Caldas(Institute of Cancer Research), Fabien Calvo(Wellcome Sanger Institute), Niedzica Camacho(Consorci Institut D'Investigacions Biomediques August Pi I Sunyer), Peter J. Campbell, Elı́as Campo(The University of Texas MD Anderson Cancer Center), Cinzia Cantù(University of Michigan), Shaolong Cao(University of Bern), Thomas E. Carey(Canada's Michael Smith Genome Sciences Centre), Joana Carlevaro-Fita, Rebecca Carlsen(University of Pavia), Ivana Cataldo(La Trobe University), Mario Cazzola(University of Alabama at Birmingham), Jonathan Cebon(Toronto General Hospital), Robert J. Cerfolio(Icahn School of Medicine at Mount Sinai), Dianne Chadwick(University of Tasmania), Dimple Chakravarty(German Cancer Research Center), Drc Chalmers(University of Ottawa), Calvin Wing Yiu Chan(Ontario Institute for Cancer Research), Kin Chan(Mayo Clinic in Arizona), Michelle Chan‐Seng‐Yue(Garvan Institute of Medical Research), Vishal S. Chandan(National Institutes of Health), David K. Chang(Garvan Institute of Medical Research), Stephen J. Chanock(Ontario Institute for Cancer Research), Lorraine A. Chantrill(Johns Hopkins University), Aurélien Chateigner(Hiroshima University), Nilanjan Chatterjee(Memorial Sloan Kettering Cancer Center), Kazuaki Chayama(University of California, San Francisco), Hsiao-Wei Chen(The University of Texas MD Anderson Cancer Center), Jieming Chen(The University of Texas MD Anderson Cancer Center), Ken Chen(University of California San Diego), Yiwen Chen(Broad Institute), Zhaohong Chen(Mayo Clinic), Andrew D. Cherniack(The University of Sydney), Jeremy Chien(University of Cambridge), Yoke-Eng Chiew(Broad Institute), Suet‐Feung Chin, Juok Cho(Korea Advanced Institute of Science and Technology), Sunghoon Cho(Electronics and Telecommunications Research Institute), Jung Kyoon Choi(Institut National du Cancer), Wan Choi(The University of Texas MD Anderson Cancer Center), Christine Chomienne(National Cancer Centre Singapore), Zechen Chong(The University of Sydney), Su Pin Choo(The University of Queensland), Angela Chou(The University of Melbourne), Angelika N. Christ(Canada's Michael Smith Genome Sciences Centre), Elizabeth L. Christie(Broad Institute), Eric Chuah(Broad Institute), Carrie Cibulskis, Kristian Cibulskis(Wellcome Sanger Institute), Sara Cingarlini(University Hospital Schleswig-Holstein), Peter Clapham(Ontario Institute for Cancer Research), Alexander Claviez(University of Auckland), Sean P. Cleary(Royal Children's Hospital), Nicole Cloonan, Marek Cmero(University Health Network), Colin C. Collins(University of Glasgow), Ashton A. Connor(University of East Anglia), Susanna L. Cooke(Johns Hopkins University), Colin S. Cooper, Leslie Cope(James S. McDonnell Foundation), Vincenzo Corbo(Victorian Institute of Forensic Medicine), Matthew G. Cordes(Harvard University), Stephen Cordner(Baylor College of Medicine), Isidro Cortés‐Ciriano(The University of Melbourne), Kyle R. Covington(University of California, Santa Cruz), Prue A. Cowin(Broad Institute), Brian Craft(The University of Texas MD Anderson Cancer Center), David Craft(University of Cologne), Chad J. Creighton(The University of Texas MD Anderson Cancer Center), Yupeng Cun(Duke-NUS Medical School), Erin Curley(Ontario Institute for Cancer Research), Ioana Cutcutache(The University of Texas MD Anderson Cancer Center), Karolina Czajka(The University of Sydney), Bogdan Czerniak(Johns Hopkins University), Rebecca A. Dagg(University of Verona), Ludmila Danilova(Cornell University), Maria Vittoria Davì(Wellcome Sanger Institute), Natalie R. Davidson(University of North Carolina at Chapel Hill), Helen Davies(Seven Bridges Genomics (United States)), Ian J. Davis(Wellcome Sanger Institute), Brandi N. Davis‐Dusenbery(Stanford University), Kevin J. Dawson(The University of Sydney), Francisco M. De La Vega(Broad Institute), Ricardo De Paoli‐Iseppi(University of Padua), Timothy Defreitas(University of Geneva), Angelo Paolo Dei Tos(National Institutes of Health), Olivier Delaneau(The Francis Crick Institute), John A. Demchok(Universitat Pompeu Fabra), Jonas Demeulemeester(National University of Singapore), German Demidov(Royal Marsden NHS Foundation Trust), Deniz Demircioğlu(Ontario Institute for Cancer Research), Nening M. Dennis(The Francis Crick Institute), Robert E. Denroche(The Francis Crick Institute), Stefan C. Dentro(Massachusetts General Hospital), Nikita Desai(University of Toronto), Vikram Deshpande(Institut Jules Bordet), Amit G. Deshwar(Universitat Pompeu Fabra), Christine Desmedt(Canada's Michael Smith Genome Sciences Centre), Jordi Deu-Pons(Princess Margaret Cancer Centre), Noreen Dhalla(Cornell University), Neesha C. Dhani(Shadyside Hospital), Priyanka Dhingra(Wellesley College), Rajiv Dhir(Uppsala University), Anthony DiBiase(James S. McDonnell Foundation), Klev Diamanti(Hefei University of Technology), Li Ding(Cedars-Sinai Medical Center), Shuai Ding(University of Antwerp), Huy Q. Dinh(Baylor College of Medicine), Luc Dirix, HarshaVardhan Doddapaneni(University of California San Diego), Nilgun Donmez(University of Pennsylvania), Michelle T. Dow(Universitat Pompeu Fabra), Ronny Drapkin(University of Cambridge), Oliver Drechsel(Wellcome Sanger Institute), Ruben M. Drews(Royal Marsden NHS Foundation Trust), Serge Serge(Barcelona Supercomputing Center), Tim Dudderidge(Broad Institute), Ana Dueso-Barroso(Wellcome Trust), Andrew Dunford(Ontario Institute for Cancer Research), Michael Dunn(University of Glasgow), Lewis Jonathan Dursi(QIMR Berghofer Medical Research Institute), Fraser R. Duthie(Ontario Institute for Cancer Research), Ken Dutton‐Regester(University of Cambridge), Jenna Eagles(Prostate Cancer Canada), Douglas F. Easton(University of Cambridge), Stuart Edmonds(Institute of Cancer Research), Paul A. Edwards(Royal Marsden NHS Foundation Trust), Sandra E. Edwards(Lund University), Rosalind A. Eeles(Heidelberg University), Anna Ehinger(German Cancer Research Center), Juergen Eils(The University of Texas MD Anderson Cancer Center), Roland Eils(University of Cambridge), Adel K. El‐Naggar(Oregon Health & Science University), Matthew Eldridge(European Molecular Biology Laboratory), Kyle Ellrott(Centre for Genomic Regulation), Serap Erkek(Ontario Institute for Cancer Research), Geòrgia Escaramís, Shadrielle M. G. Espiritu(The University of Melbourne), Xavier Estivill(Icelandic Cancer Society), Dariush Etemadmoghadam(Cornell University), Jorunn E. Eyfjord(Xijing Hospital), Bishoy M. Faltas(The University of Texas MD Anderson Cancer Center), Daiming Fan(Massachusetts General Hospital), Yu Fan(University of California San Diego), William C. Faquin(University of Padua), Claudiu Farcas(Dana-Farber Cancer Institute), Matteo Fassan(Rigshospitalet), Aquila Fatima(Ontario Institute for Cancer Research), Francesco Favero(National Institutes of Health), Nodirjon Fayzullaev(The University of Melbourne), Ina Felau(National Institutes of Health), Sián Fereday(Ontario Institute for Cancer Research), Martin L. Ferguson(German Cancer Research Center), Vincent Ferretti(Australian Institute of Tropical Health and Medicine), Lars Feuerbach(The University of Queensland), Matthew A. Field(Fondazione IRCCS Istituto Neurologico Carlo Besta), J. Lynn Fink(Royal Marsden NHS Foundation Trust), Gaetano Finocchiaro(The Francis Crick Institute), Cyril Fisher(Bioplatforms Australia), Matthew W. Fittall(University of Cambridge), Anna Fitzgerald(London Cancer), Rebecca C. Fitzgerald(Princess Margaret Cancer Centre), Adrienne M. Flanagan(European Bioinformatics Institute), Neil Fleshner(Cancer Genomics Centre), Paul Flicek(The University of Queensland), John A. Foekens(Universidade do Porto), Kwun M. Fong(University of Liverpool), Nuno A. Fonseca(Ontario Institute for Cancer Research), Christopher S. Foster(Ontario Institute for Cancer Research), Natalie S. Fox(Broad Institute), Michael Fraser(Bar-Ilan University), Scott Frazer(University of Florida), Milana Frenkel‐Morgenstern(Institute for Research in Biomedicine), William A. Friedman(James S. McDonnell Foundation), Joan Frigola(RIKEN Center for Integrative Medical Sciences), Catrina C. Fronick(RIKEN Center for Integrative Medical Sciences), Akihiro Fujimoto(The University of Tokyo), Masashi Fujita(James S. McDonnell Foundation), Masashi Fukayama(James S. McDonnell Foundation), Lucinda A. Fulton(RIKEN Center for Integrative Medical Sciences), Robert S. Fulton(The University of Texas MD Anderson Cancer Center), Mayuko Furuta(European Bioinformatics Institute), P. Andrew Futreal(Broad Institute), Anja Füllgrabe(Ontario Institute for Cancer Research), Stacey Gabriel(University of Milano-Bicocca), Steven Gallinger(Memorial Sloan Kettering Cancer Center), Carlo Gambacorti‐Passerini(BGI Group (China)), Jianjiong Gao(Dana-Farber Cancer Institute), Shengjie Gao(Oslo University Hospital), Levi A. Garraway(Wellcome Sanger Institute), Øystein Garred(The University of Melbourne), Erik Garrison(Broad Institute), Dale W. Garsed(Barcelona Supercomputing Center), Nils Gehlenborg(Jackson Laboratory), Josep L. L. Gelpi(National Institutes of Health), Joshy George(German Cancer Research Center), Daniela S. Gerhard(The University of Texas MD Anderson Cancer Center), Clarissa Gerhäuser(Yale University), Jeffrey E. Gershenwald(European Bioinformatics Institute), Mark Gerstein(Broad Institute), Moritz Gerstung(Wellcome Sanger Institute), Gad Getz(Memorial Sloan Kettering Cancer Center), Mohammed Ghori(Mayo Clinic in Arizona), Ronald Ghossein(Baylor College of Medicine), Nasra H. Giama(Ontario Institute for Cancer Research), Richard A. Gibbs(Garvan Institute of Medical Research), Bob Gibson(University of Oxford), Anthony J. Gill(Memorial Sloan Kettering Cancer Center), Pelvender Gill(Wellcome Sanger Institute), Dilip D. Giri(Cambridge University Hospitals NHS Foundation Trust), Dominik Głodzik(University of Würzburg), Vincent J. Gnanapragasam(University of California, Santa Cruz), Maria Elisabeth Goebler(University of Miami), Mary J. Goldman(European Bioinformatics Institute), Carmen Gómez(Universitat Pompeu Fabra), Santiago González(National Institute of Environmental Health Sciences), Abel González-Pérez(St Thomas' Hospital), Dmitry A. Gordenin(Osaka International Cancer Institute), James Gossage(Washington University in St. Louis), Kunihito Gotoh(Lund University), Ramaswamy Govindan(University of Glasgow), Dorthe Grabau(Ontario Institute for Cancer Research), Janet S. Graham(University of Cambridge), Robert C. Grant(National Institutes of Health), Anthony R. Green(European Bioinformatics Institute), Eric Green(University of Cambridge), Liliana Greger, Nicola Grehan(The University of Melbourne), Sonia Grimaldi(University of Chicago), Sean M. Grimmond(Leibniz Institute of Virology (LIV)), Robert L. Grossman(Memorial Sloan Kettering Cancer Center), Adam Grundhoff(Aarhus University), Gunes Gundem(Broad Institute), Qianyun Guo(Government of India), Manaswi Gupta(Universitat Pompeu Fabra), Shailja Gupta(Universitat Pompeu Fabra), Marta Gut(National Cancer Centre Singapore), Marta Gut(Broad Institute), Jonathan Göke(Christian-Albrechts-Universität zu Kiel), Gavin Ha(University of California, Santa Cruz), Andrea Haake(Friedrich-Ebert-Krankenhaus), David Haan(The Francis Crick Institute), Siegfried Haas(Brandeis University), Kerstin Haase(European Molecular Biology Laboratory), James E. Haber, Nina Habermann(Ontario Institute for Cancer Research), Faraz Hach, Syed Haider(University of Oxford), Natsuko Hama(The University of Melbourne), Freddie C. Hamdy(Stanford University), Anne Hamilton(The University of Texas Health Science Center at Houston), Mark P. Hamilton(Imperial College London), Leng Han(Goethe University Frankfurt), George B. Hanna(Broad Institute), Martin Hansmann(UC San Diego Health System), Nicholas J. Haradhvala(The University of Queensland), Olivier Harismendy(Yale University), Ivon Harliwong, Arif Harmanci, Eoghan Harrington(University of California, Santa Cruz), Takanori Hasegawa(University of Cambridge), David Haussler(Wakayama Medical University), Steve Hawkins, Shinya Hayami(University of North Carolina at Chapel Hill), Shuto Hayashi(Salford Royal NHS Foundation Trust), D. Neil Hayes(The University of Sydney), Stephen J. Hayes(Royal Marsden NHS Foundation Trust), Nicholas K. Hayward(Peking University), Steven Hazell(Children's Hospital of Philadelphia), Yao He(Universitat Pompeu Fabra), Allison P. Heath(Princess Margaret Cancer Centre), Simon Heath(The University of Texas MD Anderson Cancer Center), David W. Hedley(Broad Institute), Apurva M. Hegde(German Cancer Research Center), David I. Heiman(Memorial Sloan Kettering Cancer Center), Michael C. Heinold(Ontario Institute for Cancer Research), Zachary Heins(Karolinska Institutet), Lawrence E. Heisler(University of Toronto), Eva Hellström‐Lindberg(Hallym University), Mohamed Helmy(University of North Carolina at Chapel Hill), Seong Gu Heo(Universitat Pompeu Fabra), Austin J. Hepperla(German Cancer Research Center), José María Heredia‐Genestar(The University of Sydney), Carl Herrmann(Massachusetts General Hospital), Peter Hersey(Icelandic Cancer Society), Julian M. Hess(Wellcome Sanger Institute), Hólmfríður Hilmarsdóttir(Hokkaido University), Jonathan Hinton(Tokyo National Hospital), Satoshi Hirano(University of North Carolina at Chapel Hill), Nobuyoshi Hiraoka(Aarhus University), Katherine A. Hoadley(Simon Fraser University), Asger Hobolth(Heinrich Heine University Düsseldorf), Ermin Hodzic(Leipzig University), Jessica I. Hoell(The University of Melbourne), Steve Hoffmann(University of Southern California), Oliver Hofmann(Centre for Genomic Regulation), Andrea Holbrook(University of Nebraska Medical Center), Aliaksei Z. Holik(The University of Queensland), Michael A. Hollingsworth(Canada's Michael Smith Genome Sciences Centre), Oliver Holmes(Broad Institute), Robert A. Holt(Hallym University), Hong Chen(Syneos Health (South Korea)), Eun Pyo Hong(Amsterdam UMC Location University of Amsterdam), Jongwhi H. Hong(Aarhus University Hospital), Gerrit K. Hooijer, Henrik Hornshøj(BGI Group (China)), Fumie Hosoda(German Cancer Research Center), Yong Hou(Cambridge University Hospitals NHS Foundation Trust), Volker Hovestadt(University of North Carolina at Chapel Hill), William Howat(Johns Hopkins University), Alan P. Hoyle(Baylor College of Medicine), Ralph H. Hruban(Hong Kong University of Science and Technology), Taobo Hu(National Institutes of Health), Taobo Hu(James S. McDonnell Foundation), Xing Hua(University of North Carolina at Chapel Hill), Kuan-lin Huang(Duke-NUS Medical School), Mei Huang(Ontario Institute for Cancer Research), Mi Ni Huang(Shenzhen Bioeasy Biotechnology (China)), Vincent Huang(European Molecular Biology Laboratory), Yi Huang(Ontario Institute for Cancer Research), Wolfgang Huber(Charité - Universitätsmedizin Berlin), Thomas J. Hudson(The University of Sydney), Michael Hummel(BC Cancer Agency), Jillian A. Hung(Edinburgh Royal Infirmary), David G. Huntsman(Memorial Sloan Kettering Cancer Center), Ted R. Hupp(Max Delbrück Center), Jason T. Huse(German Cancer Research Center), Matthew R. Huska(National Institutes of Health), Barbara Hutter(Heidelberg University), Carolyn M. Hutter(Memorial Sloan Kettering Cancer Center), Daniel Hübschmann(German Cancer Research Center), Christine A. Iacobuzio–Donahue(Cornell University), Charles D. Imbusch, Marcin Imieliński(Johns Hopkins University), Seiya Imoto(Ontario Institute for Cancer Research), William B. Isaacs(The University of Tokyo), Keren Isaev(German Cancer Research Center), Shumpei Ishikawa(University of California San Diego), Murat Iskar(Michael E. DeBakey VA Medical Center), S. M. Ashiqul Islam(Seven Bridges Genomics (United States)), Michael Ittmann(Technical University of Denmark), Sinisa Ivkovic(Hanyang University), José M. G. Izarzugaza(The University of Sydney), Jocelyne Jacquemier(Glasgow Royal Infirmary), Valerie Jakrot(Ontario Institute for Cancer Research), Nigel B. Jamieson(Asan Medical Center), Gun Ho Jang(Baylor College of Medicine), Se Jin Jang(James S. McDonnell Foundation), Joy C. Jayaseelan(University of North Carolina at Chapel Hill), Reyka G. Jayasinghe, Stuart R. Jefferys(Ontario Institute for Cancer Research), Karine Jegalian(Electronics and Telecommunications Research Institute), Jennifer L. Jennings(European Molecular Biology Laboratory), Seung-Hyup Jeon(NorthShore University HealthSystem), Lara Jerman(Ontario Institute for Cancer Research), Yuan Ji(QIMR Berghofer Medical Research Institute), Wei Jiao(Garvan Institute of Medical Research), Peter A. Johansson(Ontario Institute for Cancer Research), Amber L. Johns(University of Bern), Jeremy Johns(RIKEN Center for Integrative Medical Sciences), Rory Johnson(The Francis Crick Institute), Todd A. Johnson(McGill University and Génome Québec Innovation Centre), Clemency Jolly(Icelandic Cancer Society), Yann Joly(University of North Carolina at Chapel Hill), Jón G. Jónasson(Wellcome Sanger Institute), Corbin D. Jones(German Cancer Research Center), David Jones(Cancer Research Horizons), David Jones(Canada's Michael Smith Genome Sciences Centre), Nic Jones(The Netherlands Cancer Institute), Steven J.M. Jones(Korea Advanced Institute of Science and Technology), Jos Jonkers, Young Seok Ju, Hartmut Juhl(Aarhus University Hospital), Jongsun Jung(Aarhus University Hospital), Malene Juul, Randi Istrup Juul(German Cancer Research Center), Randi Istrup Juul(German Cancer Research Center), Natalie Jäger(ETH Zurich), Rolf Kabbe(SIB Swiss Institute of Bioinformatics), André Kahles(Institute of Genetics and Cancer), Abdullah Kahraman(The University of Sydney), Vera B. Kaiser(Ontario Institute for Cancer Research), Hojabr Kakavand(German Cancer Research Center), Sangeetha Kalimuthu(Keimyung University Dongsan Medical Center), Christof von Kalle(University of Oxford), Koo Jeong Kang(Cedars-Sinai Medical Center), Katalin Karászi(University of Zagreb), Beth Y. Karlan(University Hospital Schleswig-Holstein), Rosa Karlić(Canada's Michael Smith Genome Sciences Centre), Dennis Karsch(The University of Queensland), Katayoon Kasaian(Tokyo National Hospital), Karin S. Kassahn(National Cancer Centre Japan), Hitoshi Katai(The University of Tokyo), Mamoru Kato(Hiroshima University), Hiroto Katoh(University College London), Yoshiiku Kawakami(The University of Queensland), Jonathan D. Kay(Skolkovo Institute of Science and Technology), Stephen H. Kazakoff(European Bioinformatics Institute), Marat D. Kazanov(National Institutes of Health), Maria Keays(Melanoma Institute Australia), Electron Kebebew(Broad Institute), Richard Kefford(The University of Sydney), Manolis Kellis(The University of Sydney), James G. Kench(German Cancer Research Center), Catherine J. Kennedy(Barking, Havering And Redbridge University Hospitals NHS Trust), Jules N. A. Kerssemakers(Royal Marsden NHS Foundation Trust), David Khoo, Vincent Khoo(Cornell University), Narong Khuntikeo(University College London), Ekta Khurana(National Cancer Center), Helena Kilpinen(Ewha Womans University), Hark Kyun Kim(Hanyang University), Hyung‐Lae Kim(Electronics and Telecommunications Research Institute), Hyung-Yong Kim(Broad Institute), Hyunghwan Kim(University of California San Diego), Jaegil Kim(National Cancer Center), Jihoon Kim(Samsung (South Korea)), Jong Kim(Brigham and Women's Hospital), Young-Wook Kim(Christian-Albrechts-Universität zu Kiel), Tari A. King(German Cancer Research Center), Wolfgang Hiddemann(National Institute of Environmental Health Sciences), Kortine Kleinheinz(Wellcome Sanger Institute), Leszek J. Klimczak(University Hospital Schleswig-Holstein), Stian Knappskog(McGill University and Génome Québec Innovation Centre), Michael Kneba(Seoul National University Hospital), Bartha Maria Knoppers(Uppsala University), Youngil Koh(The University of Tokyo), Jan Komorowski, Daisuke Komura(Hanyang University), Mitsuhiro Komura(Hopp Children's Cancer Center Heidelberg), Gu Kong(European Molecular Biology Laboratory), Marcel Kool(Baylor College of Medicine), Jan O. Korbel(German Cancer Research Center), Viktoriya Korchina(German Cancer Research Center), Andrey Korshunov(National Institutes of Health), Michael Koscher(Institute of Cancer Research), Roelof Koster(University of California San Diego), Zsofia Kote‐Jarai(Seven Bridges Genomics (United States)), Antonios Koures(Wellcome Sanger Institute), Milena Kovacevic(Leipzig University), Bárbara Kremeyer(Leipzig University), Helene Kretzmer(The University of Texas MD Anderson Cancer Center), Markus Kreuz(University of Göttingen), Savitri Krishnamurthy(Broad Institute), Dieter Kube(Royal Marsden NHS Foundation Trust), Kiran Kumar(Yale University), Pardeep Kumar(Hong Kong University of Science and Technology), Sushant Kumar(Memorial Sloan Kettering Cancer Center), Yogesh Kumar(Broad Institute), Ritika Kundra(University of Duisburg-Essen), Kirsten Kübler(Karolinska Institutet), Ralf Küppers(University of Southern California), Jesper Lagergren(Van Andel Institute), Phillip H. Lai(The University of Queensland), Peter W. Laird(Ontario Institute for Cancer Research), Sunil R. Lakhani(Ontario Institute for Cancer Research), Christopher M. Lalansingh(Ontario Institute for Cancer Research), Emilie Lalonde(University of Oxford), Fabien C. Lamaze(Broad Institute), Adam Lambert(University of Cologne), Eric S. Lander, Pablo Landgraf(Oslo University Hospital), Luca Landoni(University of Bern), Anita Langerød(Institut Jules Bordet), Andrés Lanzós(University of Gothenburg), Denis Larsimont(McGill University), Erik Larsson(Children's Medical Research Institute), Mark Lathrop(Berlin Institute of Health at Charité - Universitätsmedizin Berlin), Loretta M. S. Lau, Chris Lawerenz(RIKEN Center for Integrative Medical Sciences), Rita T. Lawlor(The University of Texas MD Anderson Cancer Center), Michael S. Lawrence(Seven Bridges Genomics (United States)), Alexander J. Lazar, Ana Mijalkovic Lazic(Canada's Michael Smith Genome Sciences Centre), Xuan Le(Yale University), Darlene Lee(Boston Children's Hospital), Dong-Hoon Lee(Asan Medical Center), Eunjung Alice Lee(Harvard University), Hee Jin Lee(Hanyang University), Jake June-Koo Lee(University of California, Santa Cruz), Jeong‐Yeon Lee(Institute of Biomedical Sciences, Academia Sinica), Juhee Lee(Wellcome Sanger Institute), Ming Ta Michael Lee(SIB Swiss Institute of Bioinformatics), Henry Lee-Six(Max Planck Institute for Molecular Genetics), Kjong-Van Lehmann(Charité - Universitätsmedizin Berlin), Hans Lehrach(The University of Queensland), Dido Lenze(Institute of Cancer Research), Conrad Leonard(Broad Institute), Daniel Leongamornlert(McGill University and Génome Québec Innovation Centre), Ignaty Leshchiner(Biobyte Solutions (Germany)), Louis Létourneau(Memorial Sloan Kettering Cancer Center), Ivica Letunić(Baylor College of Medicine), Douglas A. Levine(Washington University in St. Louis), Lora Lewis(BGI Group (China)), Tim Ley(Ontario Institute for Cancer Research), David K. Chang(Canada's Michael Smith Genome Sciences Centre), Constance H. Li(The University of Texas MD Anderson Cancer Center), Haiyan Irene Li(University of Oxford), Jun Li(Yale University), Lin Li(BGI Group (China)), Shantao Li(BGI Group (China)), Siliang Li(Yale University), Xiaobo Li(BGI Group (China)), Xiaotong Li(Wellcome Sanger Institute), Xinyue Li(Baylor College of Medicine), Yilong Li(Toronto General Hospital), Han Liang(German Cancer Research Center), Sheng‐Ben Liang(Broad Institute), Péter Lichter(Broad Institute), Pei Lin(National Institutes of Health), Ziao Lin(University of Oslo), W. M. Linehan(BGI Group (China)), Ole Christian Lingjærde(Memorial Sloan Kettering Cancer Center), Dongbing Liu(Princess Margaret Cancer Centre), Eric Minwei Liu(Peking University), Fei-Fei Fei Liu(Leidos (United States)), Fenglin Liu(BGI Group (China)), Jia Liu(Ontario Institute for Cancer Research), Xingmin Liu(Broad Institute), Julie Livingstone(Royal Marsden NHS Foundation Trust), Dimitri Livitz(Yale University), Naomi Livni(Leipzig University), Lucas Lochovsky(The University of Sydney), Markus Loeffler(Consorci Institut D'Investigacions Biomediques August Pi I Sunyer), Georgina V. Long(Yale University), Armando López‐Guillermo(Massachusetts General Hospital), Shaoke Lou(University College London), David N. Louis(The University of Texas MD Anderson Cancer Center), Laurence Lovat(Queen Mary University of London), Yiling Lu(Beijing Hospital), Yong‐Jie Lu, Youyong Lu(Ontario Institute for Cancer Research), Claudio Luchini(Ontario Institute for Cancer Research), Ilinca M. Lungu(University College London), Xuemei Luo(University of St Andrews), Hayley J. Luxton(Institute for Systems Biology), Andy G. Lynch(Universität Ulm), Lisa Lype(Universidad de Oviedo), Cristina López(Hong Kong University of Science and Technology), Carlos López-Otı́n(Canada's Michael Smith Genome Sciences Centre), Z. Eric(Institut Bergonié), Yussanne Ma(University of Cambridge), Gaëtan MacGrogan(University of Cambridge), Shona MacRae(Aarhus University Hospital), Geoff Macintyre(RIKEN Center for Integrative Medical Sciences), Tobias Madsen, Kazuhiro Maejima(University of Southern California), Andrea Mafficini(National Institute of Biomedical Genomics), Dennis T. Maglinte(National Institute of Biomedical Genomics), Arindam Maitra(University of Pavia), Partha P. Majumder(Simon Fraser University), Luca Malcovati, Salem Malikić(The University of Sydney), Giuseppe Malleo(Orthopädische Praxis), Graham J. Mann(Ghent University), Luisa Mantovani‐Löffler, Kathleen Marchal(James S. McDonnell Foundation), Giovanni Marchegiani(Oregon Health & Science University), Elaine R. Mardis(University of California, Santa Cruz), Adam A. Margolin(University of Cambridge), Maximillian G. Marin(Max Delbrück Center), Florian Markowetz(Duke University), Julia Markowski(Centre for Genomic Regulation), Jeffrey R. Marks(Canada's Michael Smith Genome Sciences Centre), Tomàs Marquès‐Bonet(University of Oxford), Marco A. Marra(Cancer Genomics Centre), Luke Marsden(University of Glasgow), John W.M. Martens(Institució Catalana de Recerca i Estudis Avançats), Sancha Martin(Wellcome Sanger Institute), José I. Martín‐Subero(Cornell University), Iñigo Martincorena(Broad Institute), Alexander Martinez-Fundichely(James S. McDonnell Foundation), Yosef E. Maruvka(University of Cambridge), R. Jay Mashl(University of California, Santa Cruz), Charlie E. Massie(Institute of Cancer Research), Thomas J. Matthew(Royal Marsden NHS Foundation Trust), Lucy Matthews(Oxford Nanopore Technologies (United Kingdom)), Erik Mayer(Canada's Michael Smith Genome Sciences Centre), Simon Mayes(Ontario Institute for Cancer Research), Michael Mayo(University of California, San Francisco), Faridah Mbabaali(Wellcome Sanger Institute), Karen McCune(Yale University), Ultan McDermott(James S. McDonnell Foundation), Patrick D. McGillivray(Ontario Institute for Cancer Research), Michael D. McLellan(Duke-NUS Medical School), John D. McPherson(Mount Sinai Hospital), John R. McPherson(Broad Institute), Treasa A. McPherson(Princess Margaret Cancer Centre), Samuel R. Meier(University of North Carolina at Chapel Hill), Alice Meng(Wellcome Sanger Institute), Shaowu Meng(Western Sydney University), Andrew Menzies(Institute of Cancer Research), Neil D. Merrett(The University of Melbourne), Sue Merson(Yale University), Matthew Meyerson(University of North Carolina at Chapel Hill), William Meyerson(Ontario Institute for Cancer Research), Piotr A. Mieczkowski(Seven Bridges Genomics (United States)), George L. Mihaiescu(Henry Ford Hospital), Sanja Mijalković, Tom Mikkelsen(The University of Melbourne), Michele Stanislaw Milella(James S. McDonnell Foundation), Linda Mileshkin(Garvan Institute of Medical Research), Christopher A. Miller(Ontario Institute for Cancer Research), David K. Miller(Oregon Health & Science University), Jessica K. Miller(Barcelona Supercomputing Center), Gordon B. Mills(Universität Hamburg), Ana Milovanovic, Sarah Minner(The University of Melbourne), Marco Miotto(National Institutes of Health), Gisela Mir Arnau(The University of Melbourne), Lisa Mirabello(University of Cambridge), Thomas J. Mitchell(The University of Tokyo), Thomas J. Mitchell, Satoru Miyano(Kyushu University), Naoki Miyoshi(Heidelberg Academy of Sciences and Humanities), Shinichi Mizuno(Princess Margaret Cancer Centre), Fruzsina Molnár‐Gábor(Canada's Michael Smith Genome Sciences Centre), Malcolm J. Moore(Wellcome Sanger Institute), Richard A. Moore(University of Toronto), Sandro Morganella(Roswell Park Comprehensive Cancer Center), Quaid Morris(University of North Carolina at Chapel Hill), Quaid Morris(Mayo Clinic in Arizona), Lisle E. Mose(Universitat Pompeu Fabra), Catherine D. Moser(Universitat Pompeu Fabra), Ferran Muiños(Canada's Michael Smith Genome Sciences Centre), Loris Mularoni(Canada's Michael Smith Genome Sciences Centre), Andrew J. Mungall(University of Glasgow), Karen Mungall(University of Helsinki), Elizabeth A. Musgrove(Washington University in St. Louis), Ville Mustonen(University of Tübingen), David G. Mutch(Baylor College of Medicine), Francesc Muyas(European Bioinformatics Institute), Donna M. Muzny(Penrose-St. Francis Health Services), Alfonso Muñoz(University of Bergen), Jerome K. Myers(University Hospital Ulm), Ola Myklebost(The University of Tokyo), Peter Mӧller(Garvan Institute of Medical Research), Genta Nagae(Ontario Institute for Cancer Research), Adnan M. Nagrial, Hardeep K. Nahal-Bose(RIKEN Center for Integrative Medical Sciences), Hitoshi Nakagama, Hidewaki Nakagawa(Hokkaido University), Hiromi Nakamura(RIKEN Center for Integrative Medical Sciences), Toru Nakamura(Genome Institute of Singapore), Kaoru Nakano(Wellcome Sanger Institute), Tannistha Nandi(Seven Bridges Genomics (United States)), Jyoti Nangalia(Institució Catalana de Recerca i Estudis Avançats), Mia Nastic(Yale University), Arcadi Navarro(University of Cambridge), Fábio C. P. Navarro(German Cancer Aid), David E. Neal(The University of Queensland), Gerd Nettekoven(European Bioinformatics Institute), Felicity Newell(University of California, Santa Cruz), Steven Newhouse(Duke-NUS Medical School), Yulia Newton(Chinese University of Hong Kong), Alvin Wei Tian Ng(Wellcome Sanger Institute), Anthony Ng(Royal Marsden NHS Foundation Trust), Jonathan Nicholson(Xijing Hospital), David Nicol(Massachusetts General Hospital), Yongzhan Nie(Aarhus University Hospital), G. Petur Nielsen(University of Cambridge), Morten Muhlig Nielsen(Broad Institute), Serena Nik‐Zainal(The University of Queensland), Michael S. Noble(St. Jude Children's Research Hospital), Kátia Nones(Ontario Institute for Cancer Research), Paul A. Northcott(University of California, Santa Cruz), Faiyaz Notta(University of Chicago), Brian D. O’Connor(University of Cambridge), Peter O’Donnell(Wellcome Sanger Institute), Maria O’Donovan(Mayo Clinic in Arizona), Sarah O’Meara(Cambridge University Hospitals NHS Foundation Trust), Brian Patrick O’Neill(European Bioinformatics Institute), J. Robert O’Neill(Memorial Sloan Kettering Cancer Center), David Ocaña(Carleton College), Angelica Ochoa(Royal Marsden NHS Foundation Trust), Layla Oesper(Hiroshima University), Christopher Ogden, Hideki Ohdan(University of California San Diego), Kazuhiro Ohi(The University of Melbourne), Lucila Ohno‐Machado(University of Alabama at Birmingham), Karin A. Oien(Keio University), Akinyemi I. Ojesina, Hidenori Ojima(Sage Bionetworks), Takuji Okusaka(National Cancer Centre Singapore), Larsson Omberg(Universitat Pompeu Fabra), Choon Kiat Ong(Robert Bosch Hospital), Stephan Ossowski(Ontario Institute for Cancer Research), German Ott(Ontario Institute for Cancer Research), B. F. Francis Ouellette(Ontario Institute for Cancer Research), Christine P’ng, Marta Paczkowska(The University of Melbourne), Salvatore Paiella(Garvan Institute of Medical Research), Chawalit Pairojkul(Karolinska Institutet), Marina Pajic(Wellcome Sanger Institute), Qiang Pan-Hammarström(European Bioinformatics Institute), Elli Papaemmanuil(German Cancer Research Center), Irene Papatheodorou(Hallym University), Nagarajan Paramasivam(National Cancer Center), Ji Wan Park(Samsung (South Korea)), Joong‐Won Park(Sangmyung University), Keunchil Park(Harvard University), Kiejung Park(University of North Carolina at Chapel Hill), Peter J. Park(Nottingham University Hospitals NHS Trust), Peter J. Park(NYU Langone Health), Simon L. Parsons(Ontario Institute for Cancer Research), Harvey I. Pass(Memorial Sloan Kettering Cancer Center), Danielle Pasternack(The University of Queensland), Alessandro Pastore(Institut National du Cancer), Ann‐Marie Patch, Iris Pauporté(The University of Queensland), Antonio Pea(Dana-Farber Cancer Institute), John V. Pearson(Aarhus University), Chandra Sekhar Pedamallu, Jakob Skou Pedersen(University of Cologne), Paolo Pederzoli(Cleveland Clinic), Martin Peifer(University of North Carolina at Chapel Hill), Nathan A. Pennell(University of California, San Francisco), Charles M. Perou(Mayo Clinic in Florida), Marc D. Perry(Oregon Health & Science University), Gloria M. Petersen(Christiana Care Health System), Myron Peto(European Bioinformatics Institute), Nicholas J. Petrelli(Hopp Children's Cancer Center Heidelberg), Robert Petryszak(McGill University and Génome Québec Innovation Centre), Stefan M. Pfister(Universitat Pompeu Fabra), Mark Phillips(Children's Medical Research Institute), Oriol Pich(SRA International (United States)), Hilda A. Pickett(London Cancer), Todd Pihl(Guy's Hospital), Nischalan Pillay(Garvan Institute of Medical Research), Sarah E. Pinder(Macquarie University), Mark Pinese(European Molecular Biology Laboratory), Andreia V. Pinho(Inserm), Esa Pitkänen(Spanish National Cancer Research Centre), Xavier Pivot(German Cancer Aid), Elena Piñeiro-Yáñez(German Cancer Research Center), Laura Planko(Broad Institute), Christoph Plass(Spanish National Cancer Research Centre), Paz Polak(Institutul Clinic Fundeni), Tirso Pons, Irinel Popescu(Universitat Pompeu Fabra), Olga Potapova(Royal Surrey County Hospital), Aparna Prasad(German Cancer Research Center), Shaun R. Preston(QIMR Berghofer Medical Research Institute), Manuel Prinz(Ontario Institute for Cancer Research), Antonia L. Pritchard(Cambridge University Hospitals NHS Foundation Trust), Stephenie D. Prokopec(Universidad de Oviedo), Elena Provenzano(University of North Carolina at Chapel Hill), Xosé S. Puente(Barcelona Supercomputing Center), Sonia Puig(Ghent University), Montserrat Puiggròs(The University of Sydney), Sergio Pulido-Tamayo(Ninewells Hospital), Gulietta M. Pupo(The University of Queensland), Colin A. Purdie(Centre for Genomic Regulation), Michael C. Quinn(Medical College of Wisconsin), Raquel Rabionet(German Cancer Research Center), Janet S. Rader(Seven Bridges Genomics (United States)), Bernhard Radlwimmer(European Molecular Biology Laboratory), Petar Radovic(Wellcome Sanger Institute), Benjamin Raeder(Wellcome Sanger Institute), Keiran Raine(Wellcome Sanger Institute), Manasa Ramakrishna(Emory University), Kamna Ramakrishnan(Princeton University), Suresh S. Ramalingam(Vanderbilt University), Benjamin J. Raphael(European Molecular Biology Laboratory), W. Kimryn Rathmell(Heinrich Heine University Düsseldorf), Tobias Rausch(Ontario Institute for Cancer Research), Guido Reifenberger(Memorial Sloan Kettering Cancer Center), Jüri Reimand(Memorial Sloan Kettering Cancer Center), Jorge S. Reis‐Filho(Institute for Research in Biomedicine), Victor E. Reuter(Princeton University), Iker Reyes-Salazar(Institute for Systems Biology), Matthew A. Reyna(Harvard University), Sheila M. Reynolds(McGill University), Esther Rheinbay(Dana-Farber Cancer Institute), Yasser Riazalhosseini(Christian-Albrechts-Universität zu Kiel), Andrea L. Richardson(The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute), Julia Richter(Lund University), Matthew D. Ringel(Yokohama City University), Markus Ringnér(German Cancer Research Center), Yasushi Rino(University of North Carolina at Chapel Hill), Karsten Rippe(Mayo Clinic in Arizona), Jeffrey Roach(Wellcome Sanger Institute), Lewis R. Roberts(Washington State University), Nicola D. Roberts(Canada's Michael Smith Genome Sciences Centre), Steven A. Roberts(The University of Queensland), A. Gordon Robertson(Barcelona Supercomputing Center), Alan J. Robertson(Universidade de Santiago de Compostela), Javier Bartolomé Rodriguez(Cancer Genomics Centre), Bernardo Rodriguez-Martin(University of Toronto), F. Germán Rodríguez-González(Universitätsklinikum Gießen und Marburg), Michael H. A. Roehrl(National Cancer Centre Japan), Marius Rohde(Institut de Recherche en Cancérologie de Montpellier), Hirofumi Rokutan(Garvan Institute of Medical Research), Gilles Romieu(Norfolk and Norwich University Hospital), Ilse Rooman(Broad Institute), Tom Roques(Broad Institute), Daniel Rosebrock, Mara Rosenberg(University of Würzburg), Philip Rosenstiel(Royal Marsden NHS Foundation Trust), Andreas Rosenwald(Barcelona Supercomputing Center), Edward Rowe(Duke-NUS Medical School), Romina Royo(University of Toronto), Steve Rozen(University of Bern), Yulia Rubanova(Universitat Pompeu Fabra), Mark A. Rubin(European Molecular Biology Laboratory), Carlota Rubio-Pérez, Vasilisa A. Rudneva, Borislav C. Rusev(ETH Zurich), Andrea Ruzzenente(Universitat Pompeu Fabra), Gunnar Rätsch(Ontario Institute for Cancer Research), Radhakrishnan Sabarinathan(Canada's Michael Smith Genome Sciences Centre), Veronica Y. Sabelnykova(Simon Fraser University), Sara Sadeghi(National Institute of Environmental Health Sciences), S. Cenk Sahinalp(National Cancer Centre Japan), Natalie Saini(Broad Institute), Mihoko Saito-Adachi(Ontario Institute for Cancer Research), Gordon Saksena(GZA Ziekenhuizen Campus Sint-Augustinus), Adriana Salcedo(Yale University), Roberto Salgado(Broad Institute), Leonidas Salichos(Analytical Biological Services (United States)), Richard Sallari, Charles Saller(Ontario Institute for Cancer Research), Roberto Salvia(The University of Sydney), Michelle Sam(Memorial Sloan Kettering Cancer Center), Jaswinder S. Samra(Memorial Sloan Kettering Cancer Center), Francisco Sánchez-Vega(University of North Carolina at Chapel Hill), Chris Sander(Tata Memorial Hospital), Grant Sanders(Simon Fraser University), Rajiv Sarin(RIKEN Center for Integrative Medical Sciences), Iman Sarrafi(University of Oslo), Aya Sasaki-Oku(Universität Hamburg), Torill Sauer(The University of Sydney), Guido Sauter, Robyn P.M. Saw(Hunter Water), Maria Scardoni, Christopher J. Scarlett(Centre international de recherche sur le cancer), Aldo Scarpa(German Cancer Research Center), Ghislaine Scélo(Canada's Michael Smith Genome Sciences Centre), Dirk Schadendorf, Jacqueline E. Schein(German Cancer Research Center), Markus B. Schilhabel(Charité - Universitätsmedizin Berlin), Matthias Schlesner(James S. McDonnell Foundation), Thorsten Schlomm(The University of Sydney), Heather K. Schmidt(Christian-Albrechts-Universität zu Kiel), Sarah‐Jane Schramm(Memorial Sloan Kettering Cancer Center), Stefan Schreiber(Dana-Farber Cancer Institute), Nikolaus Schultz(German Cancer Research Center), Steven E. Schumacher(The University of Sydney), Roland F. Schwarz(Cancer Research Horizons), Richard A. Scolyer(Beth Israel Deaconess Medical Center), David W. Scott(University of Pittsburgh), Ralph Scully(Massachusetts Eye and Ear Infirmary), Raja S. Seethala(Mount Sinai Hospital), Ayellet V. Segrè(Institute of Genetics and Cancer), Iris Selander(Memorial Sloan Kettering Cancer Center), Colin A. Semple(NorthShore University HealthSystem), Yasin Şenbabaoğlu, Subhajit Sengupta(University of Toronto), Elisabetta Sereni(Massachusetts General Hospital), Stefano Serra(The University of Melbourne), Dennis C. Sgroi(Cambridge University Hospitals NHS Foundation Trust), Mark Shackleton(Toronto General Hospital), Nimish Shah(Bioplatforms Australia), Sagedeh Shahabi(The University of Sydney), Catherine A. Shang(Broad Institute), Ping Shang(International Genomics Consortium), Ofer Shapira(Harvard University), Troy Shelton(Van Andel Institute), Ciyue Shen(Wellcome Sanger Institute), Hui Shen(University of Toronto), Rebecca Shepherd(University of North Carolina at Chapel Hill), Ruian Shi(Ontario Institute for Cancer Research), Yan Shi, Yu-Jia Shiah(Dana-Farber Cancer Institute), Tatsuhiro Shibata, Juliann Shih(Japan Agency for Medical Research and Development), Eigo Shimizu(Korea University), Kiyo Shimizu, Seung Jun Shin, Yuichi Shiraishi(Institute for Systems Biology), Tal Shmaya(Ontario Institute for Cancer Research), Ilya Shmulevich(European Bioinformatics Institute), Solomon I. Shorser, Charles Short(Stanford University), Raunak Shrestha(Walter Reed National Military Medical Center), Suyash Shringarpure(University of Toronto), Craig D. Shriver(University of Copenhagen), Shimin Shuai(Universität Ulm), Nikos Sidiropoulos(Cancer Genomics Centre), Reiner Siebert(Heidelberg University), Anieta M. Sieuwerts(Harvard University), Lina Sieverling, Sabina Signoretti, Katarzyna Sikora(Universität Hamburg), Michele Simbolo(University of North Carolina at Chapel Hill), Ronald Simon(University of Toronto), Janae V. Simons(The University of Queensland), Jared T. Simpson(Memorial Sloan Kettering Cancer Center), Peter T. Simpson(Stanford University), Samuel Singer(Canada's Michael Smith Genome Sciences Centre), Nasa Sinnott-Armstrong(University of North Carolina at Chapel Hill), Payal Sipahimalani(Cancer Genomics Centre), Tara Skelly(Oregon Health & Science University), Marcel Smid(University of California, San Francisco), Jaclyn Smith(Memorial Sloan Kettering Cancer Center), Karen Smith‐McCune(National Institutes of Health), Nicholas D. Socci(University of North Carolina at Chapel Hill), Heidi J. Sofia(National Institutes of Health), Matthew G. Soloway(The University of Texas MD Anderson Cancer Center), Lei Song(University Hospitals Coventry and Warwickshire NHS Trust), Anil K. Sood(University of California San Diego), Sharmila Sothi(University of California, Santa Cruz), Christos Sotiriou(Radboud University Nijmegen), Cameron M. Soulette(Oregon Health & Science University), Paul N. Span, Paul T. Spellman(The University of Sydney), Nicola Sperandio(Broad Institute), Andrew J. Spillane(University of Chicago), Oliver Spiro(Lund University), Jonathan Spring(Leipzig University), Johan Staaf(Sankt-Antonius-Hospital Eschweiler), Peter F. Stadler(Memorial Sloan Kettering Cancer Center), Peter Staib(Wellcome Sanger Institute), Stefan G. Stark(University of Iceland), Lucy Stebbings(European Bioinformatics Institute), Ólafur Andri Stefánsson(Ontario Institute for Cancer Research), Oliver Stegle(Ninewells Hospital), Lincoln D. Stein(Broad Institute), Alasdair Stenhouse(Universität Ulm), Chip Stewart(Universitat Pompeu Fabra), Stephan Stilgenbauer(Wellcome Sanger Institute), Miranda D. Stobbe(The University of Sydney), Michael R. Stratton(Oregon Health & Science University), Jonathan R. Stretch(University of California, Santa Cruz), Adam J. Struck(China National GeneBank), Joshua M. Stuart(BGI Group (China)), Henk G. Stunnenberg(The University of Texas MD Anderson Cancer Center), Hong Su(Ontario Institute for Cancer Research), Xiaoping Su(European Molecular Biology Laboratory), Ren Sun(Universitat Pompeu Fabra), Stéphanie Sungalee(Yokohama City University), Hana Sušak(Radboud University Nijmegen), Akihiro Suzuki(Christian-Albrechts-Universität zu Kiel), Fred C.G.J. Sweep(German Cancer Research Center), Monika Szczepanowski(Japan Agency for Medical Research and Development), Holger Sültmann(Canada's Michael Smith Genome Sciences Centre), Takashi Yugawa(Universitat Pompeu Fabra), Angela Tam(Singapore General Hospital), David Tamborero(University of North Carolina at Chapel Hill), Benita Kiat Tee Tan(SingHealth), Donghui Tan, Patrick Tan, Hiroko Tanaka(University of Helsinki), Hirokazu Taniguchi(The Francis Crick Institute), Tomas Tanskanen(National Institutes of Health), Maxime Tarabichi(Cambridge University Hospitals NHS Foundation Trust), Roy Tarnuzzer(Ontario Institute for Cancer Research), Patrick Tarpey(The University of Tokyo), Morgan L. Taschuk(Columbia University Irving Medical Center), Kenji Tatsuno(The University of Queensland), Simon Tavaré(Broad Institute), Darrin F. Taylor(Wellcome Sanger Institute), Amaro Taylor‐Weiner(Duke-NUS Medical School), Jon W. Teague(The University of Sydney), Bin Tean Teh(Universidade de Santiago de Compostela), Varsha Tembe(Ontario Institute for Cancer Research), Javier Temes(University of Nebraska Medical Center), Kevin Thai(Canada's Michael Smith Genome Sciences Centre), Sarah P. Thayer(Centre Léon Bérard), Nina Thiessen(Royal Marsden NHS Foundation Trust), Gilles Thomas(Royal Marsden NHS Foundation Trust), Sarah Thomas(Ninewells Hospital), Alan Thompson(The University of Sydney), Alastair M. Thompson(Mayo Clinic in Arizona), John F. Thompson(The University of Melbourne), R. Houston Thompson(University of North Carolina at Chapel Hill), Heather Thorne(McGill University and Génome Québec Innovation Centre), Leigh B. Thorne(Broad Institute), Adrian Thorogood(Seven Bridges Genomics (United States)), Grace Tiao(Ontario Institute for Cancer Research), Nebojša Tijanić(Royal National Orthopaedic Hospital), Lee E. Timms(Universidade de Vigo), Roberto Tirabosco(Istituto Tumori Bari), Marta Tojo(Garvan Institute of Medical Research), Stefania Tommasi(German Cancer Research Center), Christopher W. Toon(Barcelona Supercomputing Center), Umut H. Toprak(University of Verona), David Torrents(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Giampaolo Tortora, Jörg Tost(Maastricht University), Yasushi Totoki(The University of Melbourne), David Townend(Université Claude Bernard Lyon 1), Nadia Traficante(Centre for Genomic Regulation), Isabelle Treilleux(University of Göttingen), Jean-Rémi Trotta(University Health Network), Lorenz Trümper(Tokyo Medical and Dental University), Ming‐Sound Tsao(Wellcome Sanger Institute), Tatsuhiko Tsunoda(University Hospitals Birmingham NHS Foundation Trust), José M. C. Tubío(Queen's University Belfast), Olga Tucker(Oxford Nanopore Technologies (United Kingdom)), Richard Turkington(Dana-Farber Cancer Institute), Daniel J. Turner(Wakayama Medical University), Andrew Tutt(The University of Texas MD Anderson Cancer Center), Masaki Ueno(Johns Hopkins University), Naoto T. Ueno(Uppsala University), Christopher B. Umbricht(University of Southampton), Husen M. Umer(European Bioinformatics Institute), Tim Underwood, Lara Urban(The University of Tokyo), Tomoko Urushidate(Tallinn University of Technology), Tetsuo Ushiku(Institució Catalana de Recerca i Estudis Avançats), Liis Uusküla-Reimand(University of Southern California), Alfonso Valencia(University of Antwerp), David Van Den Berg(The Francis Crick Institute), Steven Van Laere(Emory University), Peter Van Loo(University of Antwerp), Erwin G. Van Meir(University Health Network), Gert G. Van den Eynden(University of Leeds), Theodorus van der Kwast(Norwegian University of Science and Technology), Naveen Vasudev(The University of Melbourne), Miguél Vázquez(University of North Carolina at Chapel Hill), Ravikiran Vedururu(University of Toronto), Umadevi Veluvolu(Ghent University), Shankar Vembu(University of Antwerp), Chao Li(University of Oxford), Peter Vermeulen, Clare Verrill(Barcelona Supercomputing Center), Alain Viari, David Vicente(Government of India), Caterina Vicentini(University of Latvia), K. VijayRaghavan(The University of Sydney), Juris Vīksna(Barcelona Supercomputing Center), Ricardo E. Vilain(Inserm), Izar Villasante(Tampere University Hospital), Anne Vincent‐Salomon(Broad Institute), Tapio Visakorpi(QIMR Berghofer Medical Research Institute), Douglas Voet(University of Cambridge), Paresh Vyas(The University of Queensland), Ignacio Vázquez-Garćıa(The University of Queensland), Nick M. Waddell(Uppsala University), Nicola Waddell(Ontario Institute for Cancer Research), Claes Wadelius(Universität Ulm), Lina Wadi(Broad Institute), Rabea Wagener(BGI Group (China)), Jeremiah A. Wala(Xi'an Jiaotong University), Jian Wang(Baylor College of Medicine), Jiayin Wang(German Cancer Research Center), Linghua Wang(The University of Texas MD Anderson Cancer Center), Qi Wang(Baylor College of Medicine), Wenyi Wang(National Institutes of Health), Yumeng Wang(The University of Melbourne), Zhining Wang(Max Planck Institute for Molecular Genetics), Paul Waring(Yale University), Hans-Jörg Warnatz(Cambridge University Hospitals NHS Foundation Trust), Jonathan Warrell(European Molecular Biology Laboratory), Anne Y. Warren(University of Oxford), Sebastian M. Waszak(German Cancer Research Center), David C. Wedge(Augusta University), Dieter Weichenhan(The University of Texas MD Anderson Cancer Center), Paul Weinberger(European Molecular Biology Laboratory), John N. Weinstein(University of Southern California), Joachim Weischenfeldt(Wythenshawe Hospital), Daniel J. Weisenberger(Washington University in St. Louis), Ian Welch(Leibniz Institute for Baltic Sea Research Warnemünde), Michael C. Wendl(Centre for Human Genetics), Johannes Werner(Baylor College of Medicine), Justin P. Whalley(University College London), David A. Wheeler(Mayo Clinic in Arizona), Hayley C. Whitaker(University of North Carolina at Chapel Hill), Dennis A. Wigle(University of California San Diego), Matthew D. Wilkerson(The University of Sydney), Ashley Williams(Ontario Institute for Cancer Research), James S. Wilmott(Ontario Institute for Cancer Research), Gavin W. Wilson(Nationwide Children's Hospital), Julie M. Wilson(Mayo Clinic in Arizona), Richard K. Wilson(University of Toronto), Boris Winterhoff(Poznan University of Medical Sciences), Jeffrey A. Wintersinger(German Cancer Research Center), Maciej Wiznerowicz(National Cancer Centre Singapore), Stephan Wolf(James S. McDonnell Foundation), Bernice H. Wong(Washington University in St. Louis), Tina Wong(Electronics and Telecommunications Research Institute), Winghing Wong(The University of Queensland), Youngchoon Woo(University of Toronto), Scott Wood(Ontario Institute for Cancer Research), Bradly G. Wouters(MRC University of Glasgow Centre for Virus Research), A. Jordan Wright(Stanford University), Derek Wright(Massachusetts General Hospital), Mark H. Wright, Chin‐Lee Wu(Oregon Health & Science University), Dai‐Ying Wu(Garvan Institute of Medical Research), Guanming Wu(BGI Group (China)), Jianmin Wu(Duke-NUS Medical School), Kui Wu(Hong Kong University of Science and Technology), Yang Wu(Baylor College of Medicine), Zhenggang Wu(Huazhong University of Science and Technology), Xi Liu(Ontario Institute for Cancer Research), Tian Xia(New York Genome Center), Qian Xiang(Peking University), Xiao Xiao(BGI Group (China)), Rui Xing(The University of Queensland), Heng Xiong(Johns Hopkins University), Qinying Xu(Hong Kong University of Science and Technology), Yanxun Xu(The University of Osaka), Hong Xue(Heidelberg University), Shinichi Yachida, Sergei Yakneen(Ontario Institute for Cancer Research), Rui Yamaguchi(Tokyo Women's Medical University), Takafumi N. Yamaguchi(The University of Tokyo), Masakazu Yamamoto(Wakayama Medical University), Shogo Yamamoto(University of Toronto), Hiroki Yamaue(BGI Group (China)), Fan Yang(The University of Sydney), Huanming Yang(National Institutes of Health), Jean Yang(University of Chicago), Liming Yang(Hefei University of Technology), Lixing Yang(University of Cologne), Shanlin Yang(University of Toronto), Tsun-Po Yang(New York Genome Center), Yang Yang(Max Planck Institute for Molecular Genetics), Xiaotong Yao(Wellcome Sanger Institute), Marie‐Laure Yaspo(Buck Institute for Research on Aging), Lucy Yates(China National GeneBank), Christina Yau(Xi'an Jiaotong University), Chen Ye(Memorial Sloan Kettering Cancer Center), Kai Ye(Korea Advanced Institute of Science and Technology), Venkata Yellapantula(Seoul National University Hospital), Christopher J. Yoon(Ontario Institute for Cancer Research), Sung-Soo Yoon(Chinese University of Hong Kong), Fouad Yousif(The University of Texas MD Anderson Cancer Center), Jun Yu(Duke-NUS Medical School), Kaixian Yu(Ruijin Hospital), Willie Yu(University of Glasgow), Yingyan Yu(NorthShore University HealthSystem), Ke Yuan(Ontario Institute for Cancer Research), Yuan Yuan(Ontario Institute for Cancer Research), Denis Yuen(Oslo University Hospital), Christina K. Yung(Wellcome Sanger Institute), Olga Zaikova(German Cancer Research Center), Jorge Zamora(National Institutes of Health), Marc Zapatka(National Center for Tumor Diseases), Jean C. Zenklusen(Epworth Hospital), Thorsten Zenz(Harvard University), Nikolajs Zeps(Peking University), Cheng‐Zhong Zhang(Broad Institute), Fan Zhang(Second Military Medical University), Hailei Zhang(Memorial Sloan Kettering Cancer Center), Hongwei Zhang(National Institutes of Health), Hongxin Zhang(Yale University), Jiashan Zhang(Ontario Institute for Cancer Research), Jing Zhang(BGI Group (China)), Junjun Zhang(Xi'an Jiaotong University), Xiuqing Zhang(The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute), Xuanping Zhang(Peking University), Yan Zhang(Baylor College of Medicine), Zemin Zhang(Peking University), Zhongming Zhao(Peking University), Liangtao Zheng(Van Andel Institute), Xiuqing Zheng(BGI Group (China)), Wanding Zhou(National Institutes of Health), Yong Zhou(The University of Texas MD Anderson Cancer Center), Bin Zhu(University of California, Santa Cruz), Hongtu Zhu(BGI Group (China)), Jingchun Zhu(Northwestern University), Shida Zhu(Wellcome Sanger Institute), Lihua Zou(The University of Sydney), Xueqing Zou(Royal Marsden NHS Foundation Trust), Anna DeFazio(Erasmus MC), Nicholas van As(The University of Melbourne), Carolien H. M. van Deurzen(The Netherlands Cancer Institute), Marc J. van de Vijver(SIB Swiss Institute of Bioinformatics), L. van’t Veer, Christian von Mering
Cited by 75Open Access
Abstract
The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data and RNA sequencing from a common set of 1220 cancer cases, we report hundreds of genes for which the presence within 100 kb of an SV breakpoint associates with altered expression. For the majority of these genes, expression increases rather than decreases with corresponding breakpoint events. Up-regulated cancer-associated genes impacted by this phenomenon include TERT, MDM2, CDK4, ERBB2, CD274, PDCD1LG2, and IGF2. TERT-associated breakpoints involve ~3% of cases, most frequently in liver biliary, melanoma, sarcoma, stomach, and kidney cancers. SVs associated with up-regulation of PD1 and PDL1 genes involve ~1% of non-amplified cases. For many genes, SVs are significantly associated with increased numbers or greater proximity of enhancer regulatory elements near the gene. DNA methylation near the promoter is often increased with nearby SV breakpoint, which may involve inactivation of repressor elements.
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