Integrative pathway enrichment analysis of multivariate omics data
Marta Paczkowska(Ontario Institute for Cancer Research), Jonathan Barenboim(Ontario Institute for Cancer Research), Nardnisa Sintupisut(Ontario Institute for Cancer Research), Natalie S. Fox(Ontario Institute for Cancer Research), Helen Zhu(Ontario Institute for Cancer Research), Diala Abd-Rabbo(Ontario Institute for Cancer Research), Miles W. Mee(Ontario Institute for Cancer Research), Paul C. Boutros(Ontario Institute for Cancer Research), PCAWG Drivers and Functional Interpretation Working Group(Wellcome Sanger Institute), Federico Abascal(The University of Texas MD Anderson Cancer Center), Samirkumar B. Amin(University of Toronto), Gary D. Bader(Broad Institute), Rameen Beroukhim(Aarhus University), Johanna Bertl(RIKEN Center for Integrative Medical Sciences), Keith A. Boroevich(Wellcome Sanger Institute), Søren Brunak(University of Bern), Peter J. Campbell(The University of Texas MD Anderson Cancer Center), Joana Carlevaro-Fita(German Cancer Research Center), Dimple Chakravarty(The University of Texas MD Anderson Cancer Center), Calvin Wing Yiu Chan(Korea Advanced Institute of Science and Technology), Ken Chen(Institute for Research in Biomedicine), Jung Kyoon Choi(Cornell University), Jordi Deu-Pons(Uppsala University), Priyanka Dhingra(German Cancer Research Center), Klev Diamanti(The University of Queensland), Lars Feuerbach(Universidade do Porto), J. Lynn Fink(Institute for Research in Biomedicine), Nuno A. Fonseca(University of Milano-Bicocca), Joan Frigola(Peter MacCallum Cancer Centre), Carlo Gambacorti‐Passerini(Princeton University), Dale W. Garsed(Harvard University), Mark Gerstein(Universitat Pompeu Fabra), Gad Getz(Aarhus University), Abel González-Pérez(Universitat Pompeu Fabra), Qianyun Guo(University of California, Santa Cruz), Marta Gut(Stanford University), David Haan(Broad Institute), Mark Hamilton(Yale University), Nicholas J. Haradhvala(University of Toronto), Arif Harmanci(German Cancer Research Center), Mohamed Helmy(Broad Institute), Carl Herrmann(Aarhus University), Julian M. Hess(Simon Fraser University), Asger Hobolth(German Cancer Research Center), Ermin Hodzic(Aarhus University Hospital), Chen Hong(University of Toronto), Henrik Hornshøj(Technical University of Denmark), Keren Isaev(University of Bern), José M. G. Izarzugaza(RIKEN Center for Integrative Medical Sciences), Rory Johnson(Aarhus University Hospital), Todd A. Johnson(Aarhus University Hospital), Malene Juul(Memorial Sloan Kettering Cancer Center), Randi Istrup Juul(SIB Swiss Institute of Bioinformatics), Andre Kahles(Broad Institute), Abdullah Kahraman(Cornell University), Manolis Kellis(Broad Institute), Ekta Khurana(National Cancer Center), Jaegil Kim(Samsung (South Korea)), Jong K. Kim(Uppsala University), Young-Wook Kim(European Bioinformatics Institute), Jan Komorowski(Yale University), Jan O. Korbel(University of Bern), Sushant Kumar(RIKEN Center for Integrative Medical Sciences), Andrés Lanzós(Yale University), Michael S. Lawrence(Memorial Sloan Kettering Cancer Center), Shantao Li(Yale University), Kjong-Van Lehmann(Yale University), Shantao Li(Broad Institute), Xiaotong Li(Memorial Sloan Kettering Cancer Center), Ziao Lin(Yale University), Eric Minwei Liu(Yale University), Lucas Lochovsky(Aarhus University Hospital), Shaoke Lou(Ghent University), Tobias Madsen(Wellcome Sanger Institute), Kathleen Marchal(Cornell University), Iñigo Martincorena(Broad Institute), Alexander Martinez‐Fundichely(Yale University), Yosef E. Maruvka(Yale University), Patrick D. McGillivray(Universitat Pompeu Fabra), William Meyerson(Universitat Pompeu Fabra), Ferran Muiños(RIKEN Center for Integrative Medical Sciences), Loris Mularoni(Aarhus University Hospital), Hidewaki Nakagawa(Samsung (South Korea)), Morten Muhlig Nielsen(Sangmyung University), Keunchil Park(Aarhus University), Kiejung Park(Universitat Pompeu Fabra), Jakob Skou Pedersen(Spanish National Cancer Research Centre), Oriol Pich(Ghent University), Tirso Pons(Princeton University), Sergio Pulido-Tamayo(Institute for Research in Biomedicine), Benjamin J. Raphael(Princeton University), Iker Reyes-Salazar(Broad Institute), Matthew A. Reyna(University of Bern), Esther Rheinbay(Universitat Pompeu Fabra), Mark A. Rubin(Universitat Pompeu Fabra), Carlota Rubio-Pérez(Simon Fraser University), Radhakrishnan Sabarinathan(Broad Institute), S. Cenk Şahinalp(Yale University), Gordon Saksena(Memorial Sloan Kettering Cancer Center), Leonidas Salichos(Broad Institute), Chris Sander(The University of Melbourne), Steven E. Schumacher(Broad Institute), Mark Shackleton(Harvard University), Ofer Shapira, Ciyue Shen(University of Toronto), Raunak Shrestha(University of Copenhagen), Shimin Shuai(German Cancer Research Center), Nikos Sidiropoulos(Stanford University), Lina Sieverling(Ontario Institute for Cancer Research), Nasa Sinnott-Armstrong(University of California, Santa Cruz), Lincoln Stein(Universitat Pompeu Fabra), Joshua M. Stuart(Broad Institute), David Tamborero(Tokyo Medical and Dental University), Grace Tiao(Uppsala University), Tatsuhiko Tsunoda(Tallinn University of Technology), Husen M. Umer(Barcelona Supercomputing Center), Liis Uusküla-Reimand(Barcelona Supercomputing Center), Alfonso Valencia(Ghent University), Miguel Vazquez(Uppsala University), Lieven P. C. Verbeke(Ontario Institute for Cancer Research), Claes Wadelius(Yale University), Lina Wadi(European Molecular Biology Organization), Jiayin Wang(University of Copenhagen), Jonathan Warrell(Baylor College of Medicine), Sebastian M. Waszak(Oregon Health & Science University), Joachim Weischenfeldt(Chinese University of Hong Kong), David A. Wheeler(Yale University), Guanming Wu(Xi'an Jiaotong University), Jun Yu(Yale University), Jing Zhang(University of Houston), Xuanping Zhang(Northwestern University), Yan Zhang(University of Zurich), Zhongming Zhao(Ontario Institute for Cancer Research), Lihua Zou(University of Helsinki), Christian von Mering(Wellcome Sanger Institute), Jüri Reimand(Ontario Institute for Cancer Research), Lauri A. Aaltonen(The University of Tokyo), Federico Abascal(Wellcome Sanger Institute), Adam Abeshouse(University of Chicago), Hiroyuki Aburatani(Keimyung University Dongsan Medical Center), David J. Adams(Gachon University Gil Medical Center), Nishant Agrawal(Hiroshima University), Keun Soo Ahn(The University of Texas MD Anderson Cancer Center), Sung‐Min Ahn(The University of Texas MD Anderson Cancer Center), Hiroshi Aikata(Memorial Sloan Kettering Cancer Center), Rehan Akbani(King Faisal Specialist Hospital & Research Centre), Kadir C. Akdemir(Spanish National Cancer Research Centre), Hikmat Al‐Ahmadie(Universität Hamburg), Sultan T. Al‐Sedairy(Ontario Institute for Cancer Research), Fátima Al‐Shahrour(The University of Texas MD Anderson Cancer Center), Malik Alawi(Wellcome Sanger Institute), Monique Albert(Canada's Michael Smith Genome Sciences Centre), Kenneth Aldape(The University of Melbourne), Ludmil B. Alexandrov(Universidade de Santiago de Compostela), Adrian Ally(Royal National Orthopaedic Hospital), Kathryn Alsop(The University of Texas MD Anderson Cancer Center), Eva G. Álvarez(Ontario Institute for Cancer Research), Fernanda Amary(Universität Ulm), Samirkumar B. Amin(The University of Queensland), Brice Aminou(Salford Royal NHS Foundation Trust), Ole Ammerpohl, Matthew J. Anderson(Oregon Health & Science University), Yeng Ang, Davide Antonello(James S. McDonnell Foundation), Pavana Anur, Samuel Aparício, Elizabeth L. Appelbaum(Hiroshima University), Yasuhito Arai(Tokyo Women's Medical University), Axel Aretz(Memorial Sloan Kettering Cancer Center), Koji Arihiro(Los Alamos National Laboratory), Shun‐ichi Ariizumi(University Health Network), Joshua Armenia(German Cancer Research Center), Laurent Arnould(Ontario Institute for Cancer Research), L. Sylvia(Universität Ulm), Yassen Assenov(University of North Carolina at Chapel Hill), Gurnit Atwal(Oslo University Hospital), Sietse Aukema(Ontario Institute for Cancer Research), J. Todd Auman(Consorci Institut D'Investigacions Biomediques August Pi I Sunyer), Miriam R. R. Aure(University of Toronto), Philip Awadalla(University of Cambridge), Marta Aymerich(James S. McDonnell Foundation), Gary D. Bader(University of Glasgow), Adrian Baez‐Ortega(Canada's Michael Smith Genome Sciences Centre), Matthew H. Bailey(University of North Carolina at Chapel Hill), Peter J. Bailey(Broad Institute), Miruna Balasundaram(University of Leeds), Saianand Balu, Pratiti Bandopadhayay(The University of Queensland), Rosamonde E. Banks(Ontario Institute for Cancer Research), Stefano Barbi(University Hospitals of Cleveland), Andrew P. Barbour(Gloucestershire Royal Hospital), Jonathan Barenboim(Ontario Institute for Cancer Research), Jill S. Barnholtz‐Sloan(Ontario Institute for Cancer Research), Hugh Barr(Barcelona Supercomputing Center), Elisabet Barrera, John Bartlett(University of Calgary), Javier Bartolomé(Oslo University Hospital), Claudio Bassi(Ontario Institute for Cancer Research), Oliver F. Bathe(Johns Hopkins University), Daniel Baumhoer(European Bioinformatics Institute), Prashant Bavi(Royal Stoke University Hospital), Stephen B. Baylin(Ontario Institute for Cancer Research), Wojciech Bażant(Wellcome Sanger Institute), Duncan Beardsmore(La Trobe University), Tim Beck(Chinese Academy of Sciences), Sam Behjati(Genome Canada), Andreas Behren(Universitat Pompeu Fabra), Beifang Niu(Buck Institute for Research on Aging), Cindy Bell(Duke Medical Center), Sergi Beltrán(Medizinische Hochschule Hannover), Christopher C. Benz(University of California San Diego), Andrew Berchuck(Cedars-Sinai Medical Center), Anke K. Bergmann(Queen Mary University of London), Erik N. Bergstrom(Leipzig University), Benjamin P. Berman(University of Southern California), Daniel M. Berney, Stephan H. Bernhart(Aarhus University Hospital), Rameen Beroukhim(Secretaria de Salud), Mario Berríos(Ontario Institute for Cancer Research), Samantha Bersani(Wellcome Sanger Institute), Johanna Bertl(University of Glasgow), Miguel Betancourt(German Cancer Research Center), Vinayak Bhandari(Duke Medical Center), Shriram G. Bhosle(Leipzig University), Andrew V. Biankin(European Bioinformatics Institute), Matthias Bieg(Massachusetts General Hospital), Darell D. Bigner(National Institute of Biomedical Genomics), Hans Binder(Oslo University Hospital), Ewan Birney(University of North Carolina at Chapel Hill), Michael Birrer(University of North Carolina at Chapel Hill), Nidhan K. Biswas, Bodil Bjerkehagen(Institute of Cancer Research), Tom Bodenheimer(Duke-NUS Medical School), Lori Boice(University of Southern California), Giada Bonizzato(Lund University), Johann S. de Bono(Heinrich Heine University Düsseldorf), Arnoud Boot(RIKEN Center for Integrative Medical Sciences), Moiz S. Bootwalla(Ontario Institute for Cancer Research), Åke Borg(Friedrich-Ebert-Krankenhaus), Arndt Borkhardt(Yale University), Keith A. Boroevich(Universitat Pompeu Fabra), Ivan Borozan(University of Oxford), Christoph W. Borst(McGill University), Marcus Bosenberg(University of California, Los Angeles), Mattia Bosio(Tampere University Hospital), Jacqueline Boultwood(Wellcome Sanger Institute), Guillaume Bourque(Canada's Michael Smith Genome Sciences Centre), Paul C. Boutros(Ontario Institute for Cancer Research), G. Steven Bova(Centre Léon Bérard), David Bowen(European Bioinformatics Institute), Reanne Bowlby(Fox Chase Cancer Center), David D.L. Bowtell(European Bioinformatics Institute), Sandrine Boyault(Centre international de recherche sur le cancer), Rich Boyce(University of East Anglia), Jeffrey M. Boyd(Radboud University Nijmegen), Alvis Brāzma(University of Toronto), Paul Brennan(The University of Texas MD Anderson Cancer Center), Daniel S. Brewer(Brigham and Women's Hospital), Arie B. Brinkman(Johns Hopkins University), Robert G. Bristow(The Netherlands Cancer Institute), Russell R. Broaddus(Broad Institute), Jane E. Brock(Canada's Michael Smith Genome Sciences Centre), Malcolm V. Brock(German Cancer Research Center), Annegien Broeks(University of Copenhagen), Angela N. Brooks(The University of Queensland), Denise Brooks(Universidade de Santiago de Compostela), Benedikt Brors(Oregon Health & Science University), Søren Brunak(German Cancer Research Center), Timothy J. C. Bruxner(Bundesministerium für Forschung, Technologie und Raumfahrt), Alicia L. Bruzos(Broad Institute), Alex Buchanan(The University of Sydney), Ivo Buchhalter(University Hospital Münster), Christiane Buchholz(Johns Hopkins University), Susan Bullman(Broad Institute), Hazel Burke(Stanford University), Birgit Burkhardt(Wellcome Sanger Institute), Kathleen H. Burns(University of California, San Francisco), John Busanovich(Ontario Institute for Cancer Research), Carlos D. Bustamante(Oslo University Hospital), Adam P. Butler(National Institutes of Health), Atul J. Butte(European Bioinformatics Institute), Niall J. Byrne(Royal Marsden NHS Foundation Trust), Anne‐Lise Børresen‐Dale(European Bioinformatics Institute), Rory Johnson(University of Cambridge), Andy Cafferkey(Institut Gustave Roussy), Declan Cahill(Institute of Cancer Research), Claudia Calabrese(Wellcome Sanger Institute), Carlos Caldas(Consorci Institut D'Investigacions Biomediques August Pi I Sunyer), Fabien Calvo, Niedzica Camacho(The University of Texas MD Anderson Cancer Center), Peter J. Campbell(University of Michigan), Elı́as Campo(University of Bern), Cinzia Cantù(Canada's Michael Smith Genome Sciences Centre), Shaolong Cao, Thomas E. Carey(University of Pavia), Joana Carlevaro-Fita(La Trobe University), Rebecca Carlsen(University of Alabama at Birmingham), Ivana Cataldo(Toronto General Hospital), Mario Cazzola(The University of Texas MD Anderson Cancer Center), Jonathan Cebon(University of Tasmania), Robert Cerfolio(Heidelberg University), Dianne Chadwick(University of Ottawa), Dimple Chakravarty(Ontario Institute for Cancer Research), Drc Chalmers(Mayo Clinic in Arizona), Calvin Wing Yiu Chan(Garvan Institute of Medical Research), Kin Chan(National Institutes of Health), Michelle Chan‐Seng‐Yue(Garvan Institute of Medical Research), Vishal S. Chandan(Ontario Institute for Cancer Research), David K. Chang(Johns Hopkins University), Stephen J. Chanock(Hiroshima University), Lorraine A. Chantrill(Memorial Sloan Kettering Cancer Center), Aurélien Chateigner(University of California, San Francisco), Nilanjan Chatterjee(The University of Texas MD Anderson Cancer Center), Kazuaki Chayama(The University of Texas MD Anderson Cancer Center), Hsiao-Wei Chen(University of California San Diego), Jieming Chen(Broad Institute), Ken Chen(Mayo Clinic), Yiwen Chen(The University of Sydney), Zhaohong Chen(University of Cambridge), Andrew D. Cherniack(Broad Institute), Jeremy Chien, Yoke-Eng Chiew(Korea Advanced Institute of Science and Technology), Suet‐Feung Chin(Electronics and Telecommunications Research Institute), Juok Cho(Institut National du Cancer), Sunghoon Cho(The University of Texas MD Anderson Cancer Center), Jung Kyoon Choi(National Cancer Centre Singapore), Wan Choi(The University of Sydney), Christine Chomienne(The University of Queensland), Zechen Chong(The University of Melbourne), Su Pin Choo(Canada's Michael Smith Genome Sciences Centre), Angela Chou(Broad Institute), Angelika N. Christ(Broad Institute), Elizabeth L. Christie, Eric Chuah(Wellcome Sanger Institute), Carrie Cibulskis(University Hospital Schleswig-Holstein), Kristian Cibulskis(Ontario Institute for Cancer Research), Sara Cingarlini(University of Auckland), Peter Clapham(Royal Children's Hospital), Alexander Claviez, Sean P. Cleary(University Health Network), Nicole Cloonan(University of Glasgow), Marek Cmero(University of East Anglia), Colin C. Collins(Johns Hopkins University), Ashton A. Connor, Susanna L. Cooke(James S. McDonnell Foundation), Colin S. Cooper(Victorian Institute of Forensic Medicine), Leslie Cope(Harvard University), Vincenzo Corbo(Baylor College of Medicine), Matthew G. Cordes(The University of Melbourne), Stephen Cordner(University of California, Santa Cruz), Isidro Cortés‐Ciriano(Broad Institute), Kyle R. Covington(Baylor College of Medicine), Prue A. Cowin(University of Cologne), Brian Craft(International Genomics Consortium), David Craft(Duke-NUS Medical School), Chad J. Creighton(Ontario Institute for Cancer Research), Yupeng Cun(The University of Texas MD Anderson Cancer Center), Erin Curley(The University of Sydney), Ioana Cutcutache(Johns Hopkins University), Karolina Czajka(University of Verona), Bogdan Czerniak(SIB Swiss Institute of Bioinformatics), Rebecca A. Dagg(Wellcome Sanger Institute), Ludmila Danilova(University of North Carolina at Chapel Hill), Maria Vittoria Davì(Seven Bridges Genomics (United States)), Natalie R. Davidson(Wellcome Sanger Institute), Helen Davies(Stanford University), Ian J. Davis(The University of Sydney), Brandi N. Davis‐Dusenbery(Broad Institute), Kevin J. Dawson(University of Padua), Francisco M. De La Vega(University of Geneva), Ricardo De Paoli‐Iseppi(National Institutes of Health), Timothy Defreitas(The Francis Crick Institute), Angelo Paolo Dei Tos(Universitat Pompeu Fabra), Olivier Delaneau(Genome Institute of Singapore), John A. Demchok(Royal Marsden NHS Foundation Trust), Jonas Demeulemeester(Ontario Institute for Cancer Research), German Demidov(The Francis Crick Institute), Deniz Demircioğlu(The Francis Crick Institute), Nening M. Dennis(Massachusetts General Hospital), Robert E. Denroche(University of Toronto), Stefan C. Dentro(Institut Jules Bordet), Nikita Desai(Universitat Pompeu Fabra), Vikram Deshpande(Canada's Michael Smith Genome Sciences Centre), Amit G. Deshwar(Princess Margaret Cancer Centre), Christine Desmedt(Cornell University), Jordi Deu-Pons(Shadyside Hospital), Noreen Dhalla(Wellesley College), Neesha C. Dhani(Uppsala University), Priyanka Dhingra(James S. McDonnell Foundation), Rajiv Dhir(Hefei University of Technology), Anthony DiBiase(Cedars-Sinai Medical Center), Klev Diamanti(University of Antwerp), Li Ding(Baylor College of Medicine), Shuai Ding, Huy Q. Dinh(University of California San Diego), Luc Dirix(University of Pennsylvania), HarshaVardhan Doddapaneni(Universitat Pompeu Fabra), Nilgun Donmez(University of Cambridge), Michelle T. Dow(Wellcome Sanger Institute), Ronny Drapkin(Royal Marsden NHS Foundation Trust), Oliver Drechsel(Barcelona Supercomputing Center), Ruben M. Drews(Broad Institute), Serge Serge(Wellcome Trust), Tim Dudderidge(Ontario Institute for Cancer Research), Ana Dueso-Barroso(University of Glasgow), Andrew Dunford(QIMR Berghofer Medical Research Institute), Michael Dunn(Ontario Institute for Cancer Research), Lewis Jonathan Dursi(University of Cambridge), Fraser R. Duthie(Prostate Cancer Canada), Ken Dutton‐Regester(University of Cambridge), Jenna Eagles(Institute of Cancer Research), Douglas F. Easton(Royal Marsden NHS Foundation Trust), Stuart Edmonds(Lund University), Paul A. Edwards(Heidelberg University), Sandra E. Edwards(German Cancer Research Center), Rosalind A. Eeles(The University of Texas MD Anderson Cancer Center), Anna Ehinger(University of Cambridge), Juergen Eils(Oregon Health & Science University), Roland Eils(European Molecular Biology Laboratory), Adel K. El‐Naggar(Centre for Genomic Regulation), Matthew Eldridge(Ontario Institute for Cancer Research), Kyle Ellrott(Centre for Genomic Regulation), Serap Erkek(The University of Melbourne), Geòrgia Escaramís(Icelandic Cancer Society), Shadrielle M. G. Espiritu(Cornell University), Xavier Estivill(Xijing Hospital), Dariush Etemadmoghadam(The University of Texas MD Anderson Cancer Center), Jórunn E. Eyfjörd(Massachusetts General Hospital), Bishoy M. Faltas(University of California San Diego), Daiming Fan(University of Padua), Yu Fan(Dana-Farber Cancer Institute), William C. Faquin(Rigshospitalet), Claudiu Farcas(Ontario Institute for Cancer Research), Matteo Fassan(National Institutes of Health), Aquila Fatima(The University of Melbourne), Francesco Favero(National Institutes of Health), Nodirjon Fayzullaev(Ontario Institute for Cancer Research), Ina Felau(German Cancer Research Center), Sián Fereday(Australian Institute of Tropical Health and Medicine), Martin L. Ferguson(The University of Queensland), Vincent Ferretti(Fondazione IRCCS Istituto Neurologico Carlo Besta), Lars Feuerbach(Royal Marsden NHS Foundation Trust), Matthew A. Field(The Francis Crick Institute), J. Lynn Fink(Bioplatforms Australia), Gaetano Finocchiaro(University of Cambridge), Cyril Fisher(London Cancer), Matthew W. Fittall(Princess Margaret Cancer Centre), Anna Fitzgerald(European Bioinformatics Institute), Rebecca C. Fitzgerald(Cancer Genomics Centre), Adrienne M. Flanagan(The University of Queensland), Neil Fleshner(European Bioinformatics Institute), Paul Flicek(University of Liverpool), John A. Foekens(University of Toronto), Kwun M. Fong(Ontario Institute for Cancer Research), Nuno A. Fonseca(Broad Institute), Christopher S. Foster(Bar-Ilan University), Natalie S. Fox(Ontario Institute for Cancer Research), Michael Fraser(Institute for Research in Biomedicine), Scott Frazer(James S. McDonnell Foundation), Milana Frenkel‐Morgenstern(RIKEN Center for Integrative Medical Sciences), William A. Friedman(RIKEN Center for Integrative Medical Sciences), Joan Frigola(The University of Tokyo), Catrina C. Fronick(James S. McDonnell Foundation), Akihiro Fujimoto(James S. McDonnell Foundation), Masashi Fujita(RIKEN Center for Integrative Medical Sciences), Masashi Fukayama(The University of Texas MD Anderson Cancer Center), Lucinda A. Fulton(European Bioinformatics Institute), Robert S. Fulton(Broad Institute), Mayuko Furuta(Ontario Institute for Cancer Research), P. Andrew Futreal(University of Milano-Bicocca), Anja Füllgrabe(Memorial Sloan Kettering Cancer Center), Stacey Gabriel(BGI Group (China)), Steven Gallinger(Dana-Farber Cancer Institute), Carlo Gambacorti‐Passerini(Oslo University Hospital), Jianjiong Gao(Wellcome Sanger Institute), Shengjie Gao(The University of Melbourne), Levi A. Garraway(Broad Institute), Øystein Garred(Barcelona Supercomputing Center), Erik Garrison(Jackson Laboratory), Dale W. Garsed(National Institutes of Health), Nils Gehlenborg(German Cancer Research Center), Josep L. L. Gelpi(The University of Texas MD Anderson Cancer Center), Joshy George(Princeton University), Daniela S. Gerhard(European Bioinformatics Institute), Clarissa Gerhäuser(Massachusetts General Hospital), Jeffrey E. Gershenwald(Wellcome Sanger Institute), Mark Gerstein(Memorial Sloan Kettering Cancer Center), Moritz Gerstung(Mayo Clinic in Arizona), Gad Getz(Baylor College of Medicine), Mohammed Ghori(Ontario Institute for Cancer Research), Ronald Ghossein(Garvan Institute of Medical Research), Nasra H. Giama(University of Oxford), Richard A. Gibbs(Memorial Sloan Kettering Cancer Center), Bob Gibson(Wellcome Sanger Institute), Anthony J. Gill(Cambridge University Hospitals NHS Foundation Trust), Pelvender Gill(University of Würzburg), Dilip D. Giri(University of California, Santa Cruz), Dominik Głodzik(University of Miami), Vincent J. Gnanapragasam(European Bioinformatics Institute), Maria Elisabeth Goebler(Institute for Research in Biomedicine), Mary J. Goldman(National Institute of Environmental Health Sciences), Carmen Gómez(St Thomas' Hospital), Santiago Gonzalez(Osaka International Cancer Institute), Abel González-Pérez(Washington University in St. Louis), Dmitry A. Gordenin(Lund University), James Gossage(University of Glasgow), Kunihito Gotoh(Ontario Institute for Cancer Research), Ramaswamy Govindan(University of Cambridge), Dorthe Grabau(National Institutes of Health), Janet S. Graham(European Bioinformatics Institute), Robert C. Grant(University of Cambridge), Anthony R. Green, Eric Green(The University of Melbourne), Liliana Greger(University of Chicago), Nicola Grehan(Leibniz Institute of Virology (LIV)), Sonia Grimaldi(Memorial Sloan Kettering Cancer Center), Sean M. Grimmond(Aarhus University), Robert L. Grossman(Broad Institute), Adam Grundhoff(Government of India), Gunes Gundem(Universitat Pompeu Fabra), Qianyun Guo(Universitat Pompeu Fabra), Manaswi Gupta(Genome Institute of Singapore), Shailja Gupta(Broad Institute), Marta Gut(Christian-Albrechts-Universität zu Kiel), Marta Gut(University of California, Santa Cruz), Jonathan Göke(Friedrich-Ebert-Krankenhaus), Gavin Ha(The Francis Crick Institute), Andrea Haake(Brandeis University), David Haan(European Molecular Biology Laboratory), Siegfried Haas, Kerstin Haase(Ontario Institute for Cancer Research), James E. Haber, Nina Habermann(University of Oxford), Faraz Hach(The University of Melbourne), Syed Haider(Stanford University), Natsuko Hama(The University of Texas Health Science Center at Houston), Freddie C. Hamdy(Imperial College London), Anne Hamilton(Goethe University Frankfurt), Mark Hamilton(Massachusetts General Hospital), Leng Han(UC San Diego Health System), George B. Hanna(The University of Queensland), Martin Hansmann(The University of Texas Health Science Center at Houston), Nicholas J. Haradhvala, Olivier Harismendy, Ivon Harliwong(University of California, Santa Cruz), Arif O. Harmanci(University of Cambridge), Eoghan Harrington(Wakayama Medical University), Takanori Hasegawa, David Haussler(University of North Carolina at Chapel Hill), Steve Hawkins(Salford Royal NHS Foundation Trust), Shinya Hayami(The University of Sydney), Shuto Hayashi(Royal Marsden NHS Foundation Trust), D. Neil Hayes(Peking University), Stephen J. Hayes(Children's Hospital of Philadelphia), Nicholas K. Hayward(Universitat Pompeu Fabra), Steven Hazell(Princess Margaret Cancer Centre), Xiaotong Yao(The University of Texas MD Anderson Cancer Center), Allison P. Heath(Broad Institute), Simon Heath(German Cancer Research Center), David W. Hedley(Memorial Sloan Kettering Cancer Center), Apurva M. Hegde(Ontario Institute for Cancer Research), David I. Heiman(Karolinska Institutet), Michael C. Heinold(University of Toronto), Zachary Heins(Hallym University), Lawrence E. Heisler(University of North Carolina at Chapel Hill), Eva Hellstrom-Lindberg(Universitat Pompeu Fabra), Mohamed Helmy(Heidelberg University), Seong Gu Heo(The University of Sydney), Austin J. Hepperla(Massachusetts General Hospital), José María Heredia‐Genestar(Icelandic Cancer Society), Carl Herrmann(Wellcome Sanger Institute), Peter Hersey(Hokkaido University), Julian M. Hess(Tokyo National Hospital), Hólmfríður Hilmarsdóttir(University of North Carolina at Chapel Hill), Jonathan Hinton(Aarhus University), Satoshi Hirano(Simon Fraser University), Nobuyoshi Hiraoka(Heinrich Heine University Düsseldorf), Katherine A. Hoadley(Leipzig University), Asger Hobolth(The University of Melbourne), Ermin Hodzic(University of Southern California), Jessica I. Hoell(Centre for Genomic Regulation), Steve Hoffmann(University of Nebraska Medical Center), Oliver Hofmann(The University of Queensland), Andrea Holbrook(Canada's Michael Smith Genome Sciences Centre), Aliaksei Z. Holik(Broad Institute), Michael A. Hollingsworth(Hallym University), Oliver Holmes(Syneos Health (South Korea)), Robert A. Holt(Amsterdam UMC Location University of Amsterdam), Chen Hong(Aarhus University Hospital), Eun Pyo Hong, Jongwhi H. Hong(BGI Group (China)), Gerrit K. Hooijer(German Cancer Research Center), Henrik Hornshøj(Cambridge University Hospitals NHS Foundation Trust), Fumie Hosoda(University of North Carolina at Chapel Hill), Yong Hou(Johns Hopkins University), Volker Hovestadt(Baylor College of Medicine), William Howat(Hong Kong University of Science and Technology), Alan P. Hoyle(National Institutes of Health), Ralph H. Hruban(James S. McDonnell Foundation), Taobo Hu(University of North Carolina at Chapel Hill), Taobo Hu(Duke-NUS Medical School), Xing Hua(Ontario Institute for Cancer Research), Kuan-lin Huang(Shenzhen Bioeasy Biotechnology (China)), Mei Huang(European Molecular Biology Laboratory), Mi Ni Huang(Ontario Institute for Cancer Research), Vincent Huang(Charité - Universitätsmedizin Berlin), Yi Huang(The University of Sydney), Wolfgang Huber(BC Cancer Agency), Thomas J. Hudson(Edinburgh Royal Infirmary), Michael Hummel(Memorial Sloan Kettering Cancer Center), Jillian A. Hung(Max Delbrück Center), David G. Huntsman(German Cancer Research Center), Ted R. Hupp(National Institutes of Health), Jason T. Huse(Heidelberg University), Matthew R. Huska(Memorial Sloan Kettering Cancer Center), Barbara Hutter(German Cancer Research Center), Carolyn M. Hutter(Cornell University), Daniel Hübschmann, Christine A. Iacobuzio–Donahue(Johns Hopkins University), Charles D. Imbusch(University of Toronto), Marcin Imieliński(The University of Tokyo), Seiya Imoto(German Cancer Research Center), William B. Isaacs(University of California San Diego), Keren Isaev(Michael E. DeBakey VA Medical Center), Shumpei Ishikawa(Seven Bridges Genomics (United States)), Murat Iskar(Technical University of Denmark), S. M. Ashiqul Islam(Hanyang University), Michael Ittmann(The University of Sydney), Sinisa Ivkovic(Glasgow Royal Infirmary), José M. G. Izarzugaza(Ontario Institute for Cancer Research), Jocelyne Jacquemier(Asan Medical Center), Valerie Jakrot(Baylor College of Medicine), Nigel B. Jamieson(James S. McDonnell Foundation), Gun Ho Jang(University of North Carolina at Chapel Hill), Se Jin Jang, Joy C. Jayaseelan(Ontario Institute for Cancer Research), Reyka G. Jayasinghe(Electronics and Telecommunications Research Institute), Stuart R. Jefferys(European Molecular Biology Laboratory), Karine Jegalian(NorthShore University HealthSystem), Jennifer L. Jennings(Ontario Institute for Cancer Research), Seung-Hyup Jeon(QIMR Berghofer Medical Research Institute), Lara Jerman(Garvan Institute of Medical Research), Yuan Ji(Ontario Institute for Cancer Research), Wei Jiao(University of Bern), Peter A. Johansson(RIKEN Center for Integrative Medical Sciences), Amber L. Johns(The Francis Crick Institute), Jeremy Johns(McGill University and Génome Québec Innovation Centre), Rory Johnson(Icelandic Cancer Society), Todd A. Johnson(University of North Carolina at Chapel Hill), Clemency Jolly(Wellcome Sanger Institute), Yann Joly(German Cancer Research Center), Jón G. Jónasson(Cancer Research Horizons), Corbin D. Jones(Canada's Michael Smith Genome Sciences Centre), David Jones(The Netherlands Cancer Institute), David Jones(Korea Advanced Institute of Science and Technology), Nic Jones, Steven J.M. Jones, Jos Jonkers(Aarhus University Hospital), Young Seok Ju(Aarhus University Hospital), Hartmut Juhl, Jongsun Jung(German Cancer Research Center), Malene Juul(German Cancer Research Center), Randi Istrup Juul(SIB Swiss Institute of Bioinformatics), Randi Istrup Juul(University of Zurich), Natalie Jäger(Institute of Genetics and Cancer), Rolf Kabbe(The University of Sydney), Andre Kahles(Ontario Institute for Cancer Research), Abdullah Kahraman(German Cancer Research Center), Vera B. Kaiser(Keimyung University Dongsan Medical Center), Hojabr Kakavand(University of Oxford), Sangeetha Kalimuthu(Cedars-Sinai Medical Center), Christof von Kalle(University of Zagreb), Koo Jeong Kang(University Hospital Schleswig-Holstein), Katalin Karászi(Canada's Michael Smith Genome Sciences Centre), Beth Y. Karlan(The University of Queensland), Rosa Karlić(Tokyo National Hospital), Dennis Karsch(National Cancer Centre Japan), Katayoon Kasaian(The University of Tokyo), Karin S. Kassahn(Hiroshima University), Hitoshi Katai(University College London), Mamoru Kato(The University of Queensland), Hiroto Katoh(Skolkovo Institute of Science and Technology), Yoshiiku Kawakami(European Bioinformatics Institute), Jonathan D. Kay(National Institutes of Health), Stephen H. Kazakoff(Melanoma Institute Australia), Marat D. Kazanov(Massachusetts Institute of Technology), Maria Keays(The University of Sydney), Electron Kebebew(The University of Sydney), Richard Kefford(German Cancer Research Center), Manolis Kellis(Barking, Havering And Redbridge University Hospitals NHS Trust), James G. Kench(Royal Marsden NHS Foundation Trust), Catherine J. Kennedy, Jules N. A. Kerssemakers(Cornell University), David Khoo(University College London), Vincent Khoo(National Cancer Center), Narong Khuntikeo(Ewha Womans University), Ekta Khurana(Hanyang University), Helena Kilpinen(Electronics and Telecommunications Research Institute), Hark Kyun Kim(Broad Institute), Hyung‐Lae Kim(University of California San Diego), Hyung-Yong Kim(National Cancer Center), Hyunghwan Kim(Samsung (South Korea)), Jaegil Kim(Brigham and Women's Hospital), Jihoon Kim(Christian-Albrechts-Universität zu Kiel), Jong K. Kim(German Cancer Research Center), Young-Wook Kim(National Institute of Environmental Health Sciences), Tari A. King(Wellcome Sanger Institute), Wolfgang Hiddemann(University Hospital Schleswig-Holstein), Kortine Kleinheinz(McGill University and Génome Québec Innovation Centre), Leszek J. Klimczak(Seoul National University Hospital), Stian Knappskog(Uppsala University), Michael Kneba(The University of Tokyo), Bartha Maria Knoppers, Youngil Koh(Hanyang University), Jan Komorowski(Hopp Children's Cancer Center Heidelberg), Daisuke Komura(European Molecular Biology Organization), Mitsuhiro Komura(Baylor College of Medicine), Gu Kong(German Cancer Research Center), Marcel Kool(German Cancer Research Center), Jan O. Korbel(National Institutes of Health), Viktoriya Korchina(Institute of Cancer Research), Andrey Korshunov(University of California San Diego), Michael Koscher(Seven Bridges Genomics (United States)), Roelof Koster(Wellcome Sanger Institute), Zsofia Kote‐Jarai(Leipzig University), Antonios Koures(Leipzig University), Milena Kovačević(The University of Texas MD Anderson Cancer Center), Bárbara Kremeyer(University of Göttingen), Helene Kretzmer(Broad Institute), Markus Kreuz(Royal Marsden NHS Foundation Trust), Savitri Krishnamurthy(Yale University), Dieter Kube(Hong Kong University of Science and Technology), Kiran Kumar(Memorial Sloan Kettering Cancer Center), Pardeep Kumar(Broad Institute), Sushant Kumar(University of Duisburg-Essen), Yogesh Kumar(Karolinska Institutet), Ritika Kundra(University of Southern California), Kirsten Kübler(Van Andel Institute), Ralf Küppers(The University of Queensland), Jesper Lagergren(Ontario Institute for Cancer Research), Phillip H. Lai(Ontario Institute for Cancer Research), Peter W. Laird(Ontario Institute for Cancer Research), Sunil R. Lakhani(University of Oxford), Christopher M. Lalansingh(Broad Institute), Emilie Lalonde(University of Cologne), Fabien C. Lamaze, Adam Lambert(Oslo University Hospital), Eric Lander(University of Bern), Pablo Landgraf(Institut Jules Bordet), Luca Landoni(University of Gothenburg), Anita Langerød(McGill University), Andrés Lanzós(Children's Medical Research Institute), Denis Larsimont(Berlin Institute of Health at Charité - Universitätsmedizin Berlin), Erik G. Larsson, Mark Lathrop(RIKEN Center for Integrative Medical Sciences), Loretta M. S. Lau(The University of Texas MD Anderson Cancer Center), Chris Lawerenz(Seven Bridges Genomics (United States)), Rita T. Lawlor, Michael S. Lawrence(Canada's Michael Smith Genome Sciences Centre), Alexander J. Lazar(Boston Children's Hospital), Ana Mijalkovic Lazic(Asan Medical Center), Xuan Le(Harvard University), Darlene Lee(Hanyang University), Donghoon Lee(University of California, Santa Cruz), Eunjung Alice Lee(Institute of Biomedical Sciences, Academia Sinica), Hee Jin Lee(Wellcome Sanger Institute), Jake June-Koo Lee(SIB Swiss Institute of Bioinformatics), Jeong‐Yeon Lee(Max Planck Institute for Molecular Genetics), Ju‐Hee Lee(Charité - Universitätsmedizin Berlin), Ming Ta Michael Lee(The University of Queensland), Henry Lee-Six(Institute of Cancer Research), Kjong-Van Lehmann(Broad Institute), Hans Lehrach(McGill University and Génome Québec Innovation Centre), Dido Lenze(Biobyte Solutions (Germany)), Conrad Leonard(Memorial Sloan Kettering Cancer Center), Daniel Leongamornlert(Baylor College of Medicine), Ignaty Leshchiner(Washington University in St. Louis), Louis Létourneau(BGI Group (China)), Ivica Letunić(Ontario Institute for Cancer Research), Douglas A. Levine(Canada's Michael Smith Genome Sciences Centre), Lora Lewis(The University of Texas MD Anderson Cancer Center), Tim Ley(University of Oxford), Chang Li(Yale University), Constance H. Li(BGI Group (China)), Haiyan Irene Li(BGI Group (China)), Jun Li(Yale University), Lin Li(BGI Group (China)), Shantao Li(Wellcome Sanger Institute), Siliang Li(Baylor College of Medicine), Xiaobo Li(Toronto General Hospital), Xiaotong Li(German Cancer Research Center), Xinyue Li(Broad Institute), Yilong Li(Harvard University Press), Han Liang(National Institutes of Health), Sheng‐Ben Liang(University of Oslo), Peter Lichter(BGI Group (China)), Pei Lin(Memorial Sloan Kettering Cancer Center), Ziao Lin(Princess Margaret Cancer Centre), W. Marston Linehan(Peking University), Ole Christian Lingjærde(Leidos (United States)), Dongbing Liu(BGI Group (China)), Eric Minwei Liu(Ontario Institute for Cancer Research), Fei-Fei Fei Liu(Broad Institute), Fenglin Liu(Royal Marsden NHS Foundation Trust), Jia Liu(Yale University), Xingmin Liu(Leipzig University), Julie Livingstone(The University of Sydney), Dimitri Livitz(Consorci Institut D'Investigacions Biomediques August Pi I Sunyer), Naomi Livni(Yale University), Lucas Lochovsky(Massachusetts General Hospital), Markus Loeffler(University College London), Georgina V. Long(The University of Texas MD Anderson Cancer Center), Armando López‐Guillermo(Queen Mary University of London), Shaoke Lou(Beijing Hospital), David N. Louis, Laurence Lovat(Ontario Institute for Cancer Research), Yiling Lu(Ontario Institute for Cancer Research), Yong‐Jie Lu(University College London), Youyong Lu(University of Cambridge), Claudio Luchini(Institute for Systems Biology), Ilinca M. Lungu(Universität Ulm), Xuemei Luo(Universidad de Oviedo), Hayley J. Luxton(Hong Kong University of Science and Technology), Andy G. Lynch(Canada's Michael Smith Genome Sciences Centre), Lisa Lype(Institut Bergonié), Cristina López(University of Cambridge), Carlos López-Otı́n(University of Cambridge), Z. Eric(Aarhus University Hospital), Yussanne Ma(RIKEN Center for Integrative Medical Sciences), Gaëtan MacGrogan, Shona MacRae(University of Southern California), Geoff Macintyre(National Institute of Biomedical Genomics), Tobias Madsen(National Institute of Biomedical Genomics), Kazuhiro Maejima(University of Pavia), Andrea Mafficini(Simon Fraser University), Dennis T. Maglinte, Arindam Maitra(The University of Sydney), Partha P. Majumder(Orthopädische Praxis), Luca Malcovati(Ghent University), Salem Malikić, Giuseppe Malleo(James S. McDonnell Foundation), Graham J. Mann(Oregon Health & Science University), Luisa Mantovani‐Löffler(University of California, Santa Cruz), Kathleen Marchal(University of Cambridge), Giovanni Marchegiani(Max Delbrück Center), Elaine R. Mardis(Duke University), Adam A. Margolin(Centre for Genomic Regulation), Maximillian G. Marin(Canada's Michael Smith Genome Sciences Centre), Florian Markowetz(University of Oxford), Julia Markowski(Cancer Genomics Centre), Jeffrey S. Marks(University of Glasgow), Tomàs Marquès‐Bonet(Institució Catalana de Recerca i Estudis Avançats), Marco A. Marra(Wellcome Sanger Institute), Luke Marsden(Cornell University), John W.M. Martens(Massachusetts General Hospital), Sancha Martin(James S. McDonnell Foundation), José I. Martín‐Subero(University of Cambridge), Iñigo Martincorena(University of California, Santa Cruz), Alexander Martinez‐Fundichely(Institute of Cancer Research), Yosef E. Maruvka(Royal Marsden NHS Foundation Trust), R. Jay Mashl(Oxford Nanopore Technologies (United Kingdom)), Charlie E. Massie(Canada's Michael Smith Genome Sciences Centre), Thomas J. Matthew(Ontario Institute for Cancer Research), Lucy Matthews(University of California, San Francisco), Erik Mayer(Wellcome Sanger Institute), Simon Mayes(Yale University), Michael Mayo(James S. McDonnell Foundation), Faridah Mbabaali(Ontario Institute for Cancer Research), Karen McCune(Duke-NUS Medical School), Ultan McDermott(Mount Sinai Hospital), Patrick D. McGillivray(Broad Institute), Michael D. McLellan(Princess Margaret Cancer Centre), John D. McPherson(University of North Carolina at Chapel Hill), John R. McPherson(Wellcome Sanger Institute), Treasa A. McPherson, Samuel R. Meier(Institute of Cancer Research), Alice Meng(Broad Institute), Shaowu Meng(Yale University), Andrew Menzies(University of North Carolina at Chapel Hill), Neil D. Merrett(Ontario Institute for Cancer Research), Sue Merson(Seven Bridges Genomics (United States)), Matthew Meyerson(Henry Ford Hospital), William Meyerson, Piotr A. Mieczkowski(The University of Melbourne), George L. Mihaiescu(James S. McDonnell Foundation), Sanja Mijalković(Garvan Institute of Medical Research), Tom Mikkelsen(Ontario Institute for Cancer Research), Michele Stanislaw Milella(Oregon Health & Science University), Linda Mileshkin(Barcelona Supercomputing Center), Christopher A. Miller(Universität Hamburg), David K. Miller, Jessica K. Miller(The University of Melbourne), Gordon B. Mills(National Institutes of Health), Ana Milovanovic(The University of Melbourne), Sarah Minner(University of Cambridge), Marco Miotto, Gisela Mir Arnau, Lisa Mirabello(Kyushu University), Thomas J. Mitchell(Heidelberg Academy of Sciences and Humanities), Thomas J. Mitchell(Princess Margaret Cancer Centre), Satoru Miyano(Canada's Michael Smith Genome Sciences Centre), Naoki Miyoshi(Wellcome Sanger Institute), Shinichi Mizuno(University of Toronto), Fruzsina Molnár-Gábor(Roswell Park Comprehensive Cancer Center), Malcolm J. Moore(University of North Carolina at Chapel Hill), Richard A. Moore(Mayo Clinic in Arizona), Sandro Morganella(Universitat Pompeu Fabra), Quaid Morris(Universitat Pompeu Fabra), Quaid Morris(Canada's Michael Smith Genome Sciences Centre), Lisle E. Mose(Canada's Michael Smith Genome Sciences Centre), Catherine D. Moser(University of Glasgow), Ferran Muiños(University of Helsinki), Loris Mularoni(Washington University in St. Louis), Andrew J. Mungall(University of Tübingen), Karen Mungall(Baylor College of Medicine), Elizabeth A. Musgrove(European Bioinformatics Institute), Ville Mustonen(Penrose-St. Francis Health Services), David G. Mutch(University of Bergen), Francesc Muyas(University Hospital Ulm), Donna M. Muzny(The University of Tokyo), Alfonso Muñoz(Garvan Institute of Medical Research), Jerome K. Myers(Ontario Institute for Cancer Research), Ola Myklebost, Peter Möller(RIKEN Center for Integrative Medical Sciences), Genta Nagae, Adnan Nagrial(Hokkaido University), Hardeep K. Nahal-Bose(RIKEN Center for Integrative Medical Sciences), Hitoshi Nakagama(Genome Institute of Singapore), Hidewaki Nakagawa(Wellcome Sanger Institute), Hiromi Nakamura(Seven Bridges Genomics (United States)), Tõru Nakamura(Institució Catalana de Recerca i Estudis Avançats), Kaoru Nakano(Yale University), Tannistha Nandi(University of Cambridge), Jyoti Nangalia(German Cancer Aid), Mia Nastic(The University of Queensland), Arcadi Navarro(European Bioinformatics Institute), Fábio C. P. Navarro(University of California, Santa Cruz), David E. Neal(Duke-NUS Medical School), Gerd Nettekoven(Chinese University of Hong Kong), Felicity Newell(Wellcome Sanger Institute), Steven Newhouse(Royal Marsden NHS Foundation Trust), Yulia Newton(Xijing Hospital), Alvin Wei Tian Ng(Massachusetts General Hospital), Chi‐Fai Ng(Aarhus University Hospital), Jonathan Nicholson(University of Cambridge), David Nicol(Broad Institute), Yongzhan Nie(The University of Queensland), G. Petur Nielsen(St. Jude Children's Research Hospital), Morten Muhlig Nielsen(Ontario Institute for Cancer Research), Serena Nik‐Zainal(University of California, Santa Cruz), Michael S. Noble(University of Chicago), Kátia Nones(University of Cambridge), Paul A. Northcott(Wellcome Sanger Institute), Faiyaz Notta(Mayo Clinic in Arizona), Brian D. O’Connor(Cambridge University Hospitals NHS Foundation Trust), Peter O’Donnell(European Bioinformatics Institute), Maria O’Donovan(Memorial Sloan Kettering Cancer Center), Sarah O’Meara(Carleton College), Brian Patrick O’Neill(Royal Marsden NHS Foundation Trust), J. Robert O’Neill(Hiroshima University), David Ocaña, Angelica Ochoa(University of California San Diego), Layla Oesper(The University of Melbourne), Christopher Ogden(University of Alabama at Birmingham), Hideki Ohdan(Keio University), Kazuhiro Ohi, Lucila Ohno‐Machado(Sage Bionetworks), Karin A. Oien(National Cancer Centre Singapore), Akinyemi I. Ojesina(Universitat Pompeu Fabra), Hidenori Ojima(Robert Bosch Hospital), Takuji Okusaka(University of Toronto), Larsson Omberg(Ontario Institute for Cancer Research), Choon Kiat Ong(Ontario Institute for Cancer Research), Stephan Ossowski, German Ott(The University of Melbourne), B. F. Francis Ouellette(Garvan Institute of Medical Research), Christine P’ng(BGI Group (China)), Marta Paczkowska(Ontario Institute for Cancer Research), Salvatore Paiella(European Bioinformatics Institute), Chawalit Pairojkul(German Cancer Research Center), Marina Pajic(Hallym University), Qiang Pan‐Hammarström(National Cancer Center), Elli Papaemmanuil(Samsung (South Korea)), Irene Papatheodorou(Sangmyung University), Nagarajan Paramasivam(Harvard University), Ji Wan Park(University of North Carolina at Chapel Hill), Joong‐Won Park(Nottingham University Hospitals NHS Trust), Keunchil Park(NYU Langone Health), Kiejung Park(Ontario Institute for Cancer Research), Peter J. Park(Memorial Sloan Kettering Cancer Center), Joel S. Parker(The University of Queensland), Simon L. Parsons(Institut National du Cancer), Harvey I. Pass, Danielle Pasternack(The University of Queensland), Alessandro Pastore(Broad Institute), Ann‐Marie Patch(Aarhus University), Iris Pauporté, Antonio Pea(University of Cologne), John V. Pearson(Cleveland Clinic), Chandra Sekhar Pedamallu(University of North Carolina at Chapel Hill), Jakob Skou Pedersen(University of California, San Francisco), Paolo Pederzoli(Mayo Clinic in Florida), Martin Peifer(Oregon Health & Science University), Nathan A. Pennell(Christiana Care Health System), Charles M. Perou(European Bioinformatics Institute), Marc D. Perry(Hopp Children's Cancer Center Heidelberg), Gloria M. Petersen(McGill University and Génome Québec Innovation Centre), Myron Peto(Universitat Pompeu Fabra), Nicholas Petrelli(Children's Medical Research Institute), Robert Petryszak(SRA International (United States)), Stefan M. Pfister(London Cancer), Mark Phillips(Guy's Hospital), Oriol Pich(Garvan Institute of Medical Research), Hilda A. Pickett(Macquarie University), Todd Pihl(European Molecular Biology Laboratory), Nischalan Pillay(Inserm), Sarah Pinder(Spanish National Cancer Research Centre), Mark Pinese(German Cancer Aid), Andreia V. Pinho(German Cancer Research Center), Esa Pitkänen(Broad Institute), Xavier Pivot(Spanish National Cancer Research Centre), Elena Piñeiro-Yáñez(Institutul Clinic Fundeni), Laura Planko, Christoph Plass(Universitat Pompeu Fabra), Paz Polak(Royal Surrey County Hospital), Tirso Pons(German Cancer Research Center), Irinel Popescu(QIMR Berghofer Medical Research Institute), Olga Potapova(Ontario Institute for Cancer Research), Aparna Prasad(Cambridge University Hospitals NHS Foundation Trust), Shaun R. Preston(Universidad de Oviedo), Manuel Prinz(University of North Carolina at Chapel Hill), Antonia L. Pritchard(Barcelona Supercomputing Center), Stephenie D. Prokopec(Ghent University), Elena Provenzano(The University of Sydney), Xosé S. Puente(Ninewells Hospital), Sonia Puig(The University of Queensland), Montserrat Puiggròs(Centre for Genomic Regulation), Sergio Pulido-Tamayo(Medical College of Wisconsin), Gulietta M. Pupo(German Cancer Research Center), Colin A. Purdie(Seven Bridges Genomics (United States)), Michael C. Quinn(European Molecular Biology Laboratory), Raquel Rabionet(Wellcome Sanger Institute), Janet S. Rader(Wellcome Sanger Institute), Bernhard Radlwimmer(Wellcome Sanger Institute), Petar Radovic(Emory University), Benjamin Raeder(Princeton University), Keiran Raine(Vanderbilt University), Manasa Ramakrishna(European Molecular Biology Laboratory), Kamna Ramakrishnan(Heinrich Heine University Düsseldorf), Suresh Ramalingam(Ontario Institute for Cancer Research), Benjamin J. Raphael(Memorial Sloan Kettering Cancer Center), W. Kimryn Rathmell(Memorial Sloan Kettering Cancer Center), Tobias Rausch(Institute for Research in Biomedicine), Guido Reifenberger(Princeton University), Jüri Reimand(Ontario Institute for Cancer Research), Jorge S. Reis‐Filho(Harvard University), Victor E. Reuter(McGill University), Iker Reyes-Salazar(Dana-Farber Cancer Institute), Matthew A. Reyna(Christian-Albrechts-Universität zu Kiel), Sheila M. Reynolds(The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute), Esther Rheinbay(Lund University), Yasser Riazalhosseini(Yokohama City University), Andrea L. Richardson(German Cancer Research Center), Julia Richter(University of North Carolina at Chapel Hill), Matthew D. Ringel(Mayo Clinic in Arizona), Markus Ringnér(Wellcome Sanger Institute), Yasushi Rino(Washington State University), Karsten Rippe(Canada's Michael Smith Genome Sciences Centre), Jeffrey Roach(The University of Queensland), Lewis R. Roberts(Barcelona Supercomputing Center), Nicola D. Roberts(Universidade de Santiago de Compostela), Steven A. Roberts(Cancer Genomics Centre), A. Gordon Robertson(University of Toronto), Alan J. Robertson(Universitätsklinikum Gießen und Marburg), Javier Bartolomé Rodriguez(National Cancer Centre Japan), Bernardo Rodríguez–Martín(Institut de Recherche en Cancérologie de Montpellier), F. Germán Rodríguez-González(Garvan Institute of Medical Research), Michael H. A. Roehrl(Norfolk and Norwich University Hospital), Marius Rohde(Broad Institute), Hirofumi Rokutan(Broad Institute), Gilles Romieu, Ilse Rooman(University of Würzburg), Tom Roques(Royal Marsden NHS Foundation Trust), Daniel Rosebrock(Barcelona Supercomputing Center), Mara Rosenberg(Duke-NUS Medical School), Philip Rosenstiel(University of Toronto), Andreas Rosenwald(University of Bern), Edward Rowe(Vall d'Hebron Institute of Oncology), Romina Royo(European Molecular Biology Laboratory), Steve Rozen, Yulia Rubanova, Mark A. Rubin(SIB Swiss Institute of Bioinformatics), Carlota Rubio-Pérez(Tata Institute of Fundamental Research), Vasilisa A. Rudneva(Ontario Institute for Cancer Research), Borislav C. Rusev(Canada's Michael Smith Genome Sciences Centre), Andrea Ruzzenente(Simon Fraser University), Gunnar Rätsch(National Institute of Environmental Health Sciences), Radhakrishnan Sabarinathan(National Cancer Centre Japan), Veronica Y. Sabelnykova(Broad Institute), Sara Sadeghi(Ontario Institute for Cancer Research), S. Cenk Şahinalp(GZA Ziekenhuizen Campus Sint-Augustinus), Natalie Saini(Yale University), Mihoko Saito-Adachi(Broad Institute), Gordon Saksena(Analytical Biological Services (United States)), Adriana Salcedo, Roberto Salgado(Ontario Institute for Cancer Research), Leonidas Salichos(The University of Sydney), Richard Sallari(Memorial Sloan Kettering Cancer Center), Charles Saller(Harvard University), Roberto Salvia(University of North Carolina at Chapel Hill), Michelle Sam(Tata Memorial Hospital), Jaswinder S. Samra(Simon Fraser University), Francisco Sánchez-Vega(RIKEN Center for Integrative Medical Sciences), Chris Sander(University of Oslo), Grant Sanders(Universität Hamburg), Rajiv Sarin(The University of Sydney), Iman Sarrafi, Aya Sasaki-Oku(Hunter Water), Torill Sauer, Guido Sauter(Centre international de recherche sur le cancer), Robyn P.M. Saw(German Cancer Research Center), Maria Scardoni(Canada's Michael Smith Genome Sciences Centre), Christopher J. Scarlett, Aldo Scarpa(German Cancer Research Center), Ghislaine Scélo(Charité - Universitätsmedizin Berlin), Dirk Schadendorf(James S. McDonnell Foundation), Jacqueline E. Schein(The University of Sydney), Markus B. Schilhabel(Christian-Albrechts-Universität zu Kiel), Matthias Schlesner(Memorial Sloan Kettering Cancer Center), Thorsten Schlomm(Dana-Farber Cancer Institute), Heather K. Schmidt(German Cancer Society), Sarah‐Jane Schramm(The University of Sydney), Stefan Schreiber(Cancer Research Horizons), Nikolaus Schultz(Beth Israel Deaconess Medical Center), Steven E. Schumacher(University of Pittsburgh), Roland F. Schwarz(Massachusetts Eye and Ear Infirmary), Richard A. Scolyer(Mount Sinai Hospital), David Scott(Institute of Genetics and Cancer), Ralph Scully(Memorial Sloan Kettering Cancer Center), Raja S. Seethala(NorthShore University HealthSystem), Ayellet V. Segrè, Iris Selander(University of Toronto), Colin A. Semple(Massachusetts General Hospital), Yasin Şenbabaoğlu(The University of Melbourne), Subhajit Sengupta(Cambridge University Hospitals NHS Foundation Trust), Elisabetta Sereni(Toronto General Hospital), Stefano Serra(Bioplatforms Australia), Dennis C. Sgroi(The University of Sydney), Mark Shackleton(Broad Institute), Nimish Shah(International Genomics Consortium), Sagedeh Shahabi(Dana-Farber Cancer Institute), Catherine A. Shang(Van Andel Institute), Ping Shang(Wellcome Sanger Institute), Ofer Shapira(University of Toronto), Troy Shelton(University of North Carolina at Chapel Hill), Ciyue Shen(Ontario Institute for Cancer Research), Hui Shen, Rebecca Shepherd(Dana-Farber Cancer Institute), Ruian Shi, Yan Shi(Japan Agency for Medical Research and Development), Yu-Jia Shiah(Korea University), Tatsuhiro Shibata, Juliann Shih, Eigo Shimizu(Institute for Systems Biology), Kiyo Shimizu(Ontario Institute for Cancer Research), Seung Jun Shin(European Bioinformatics Institute), Yuichi Shiraishi, Tal Shmaya(Stanford University), Ilya Shmulevich(Walter Reed National Military Medical Center), Solomon I. Shorser(University of Toronto), Charles Short(University of Copenhagen), Raunak Shrestha(Christian-Albrechts-Universität zu Kiel), Suyash Shringarpure(Cancer Genomics Centre), Craig D. Shriver(German Cancer Research Center), Shimin Shuai(Harvard University), Nikos Sidiropoulos, Reiner Siebert, Anieta M. Sieuwerts(Universität Hamburg), Lina Sieverling(University of North Carolina at Chapel Hill), Sabina Signoretti(University of Toronto), Katarzyna Sikora(The University of Queensland), Michele Simbolo(Memorial Sloan Kettering Cancer Center), Ronald Simon(Broad Institute), Janae V. Simons(Canada's Michael Smith Genome Sciences Centre), Jared T. Simpson(University of North Carolina at Chapel Hill), Peter T. Simpson(Cancer Genomics Centre), Samuel Singer(Oregon Health & Science University), Nasa Sinnott-Armstrong(University of California, San Francisco), Payal Sipahimalani(Memorial Sloan Kettering Cancer Center), Tara Skelly(National Institutes of Health), Marcel Smid(University of North Carolina at Chapel Hill), Jaclyn Smith(National Institutes of Health), Karen Smith‐McCune(The University of Texas MD Anderson Cancer Center), Nicholas D. Socci(University Hospitals Coventry and Warwickshire NHS Trust), Heidi J. Sofia(University of California San Diego), Matthew G. Soloway(University of California, Santa Cruz), Lei Song(Radboud University Nijmegen), Anil K. Sood(Oregon Health & Science University), Sharmila Sothi, Christos Sotiriou(The University of Sydney), Cameron M. Soulette(Broad Institute), Paul N. Span(University of Chicago), Paul T. Spellman(Lund University), Nicola Sperandio(Leipzig University), Andrew J. Spillane(Sankt-Antonius-Hospital Eschweiler), Oliver Spiro(SIB Swiss Institute of Bioinformatics), Jonathan Spring(Wellcome Sanger Institute), Johan Staaf(University of Iceland), Peter F. Stadler(German Cancer Research Center), Peter Staib(Ontario Institute for Cancer Research), Stefan G. Stark(Ninewells Hospital), Lucy Stebbings(Broad Institute), Ólafur Andri Stefánsson(Universität Ulm), Oliver Stegle(Universitat Pompeu Fabra), Lincoln Stein(Wellcome Sanger Institute), Alasdair Stenhouse(The University of Sydney), Chip Stewart(Oregon Health & Science University), Stephan Stilgenbauer(University of California, Santa Cruz), Miranda D. Stobbe(China National GeneBank), Michael R. Stratton(BGI Group (China)), Jonathan R. Stretch(The University of Texas MD Anderson Cancer Center), Adam J. Struck(Ontario Institute for Cancer Research), Joshua M. Stuart(European Molecular Biology Laboratory), Henk G. Stunnenberg(Universitat Pompeu Fabra), Hong Su(Yokohama City University), Xiaoping Su(Radboud University Nijmegen), Ren Sun(Christian-Albrechts-Universität zu Kiel), Stéphanie Sungalee(German Cancer Research Center), Hana Sušak(Japan Agency for Medical Research and Development), Akihiro Suzuki(Canada's Michael Smith Genome Sciences Centre), Fred C.G.J. Sweep(Universitat Pompeu Fabra), Monika Szczepanowski(Singapore General Hospital), Holger Sültmann(University of North Carolina at Chapel Hill), Takashi Yugawa(SingHealth), Angela Tam, David Tamborero, Benita Kiat Tee Tan(University of Helsinki), Donghui Tan(The Francis Crick Institute), Patrick Tan(National Institutes of Health), Hiroko Tanaka(Cambridge University Hospitals NHS Foundation Trust), Hirokazu Taniguchi(Ontario Institute for Cancer Research), Tomas Tanskanen(The University of Tokyo), Maxime Tarabichi(Columbia University Irving Medical Center), Roy Tarnuzzer(The University of Queensland), Patrick Tarpey(Broad Institute), Morgan L. Taschuk(Wellcome Sanger Institute), Kenji Tatsuno(SingHealth), Simon Tavaré(The University of Sydney), Darrin F. Taylor(Universidade de Santiago de Compostela), Amaro Taylor‐Weiner(Ontario Institute for Cancer Research), Jon W. Teague(University of Nebraska Medical Center), Bin Tean Teh(Canada's Michael Smith Genome Sciences Centre), Varsha Tembe(Centre Léon Bérard), Javier Temes(Royal Marsden NHS Foundation Trust), Kevin Thai(Royal Marsden NHS Foundation Trust), Sarah P. Thayer(Ninewells Hospital), Nina Thiessen(The University of Sydney), Gilles Thomas(Mayo Clinic in Arizona), Sarah Thomas(The University of Melbourne), Alan Thompson(University of North Carolina at Chapel Hill), Alastair M. Thompson(McGill University and Génome Québec Innovation Centre), John F. Thompson(Broad Institute), R. Houston Thompson(Seven Bridges Genomics (United States)), Heather Thorne(Ontario Institute for Cancer Research), Leigh B. Thorne(Royal National Orthopaedic Hospital), Adrian Thorogood(Universidade de Vigo), Grace Tiao(Istituto Tumori Bari), Nebojša Tijanić(Garvan Institute of Medical Research), Lee E. Timms(German Cancer Research Center), Roberto Tirabosco(Institució Catalana de Recerca i Estudis Avançats), Marta Tojo(University of Verona), Stefania Tommasi(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Christopher W. Toon, Umut H. Toprak(Maastricht University), David Torrents(The University of Melbourne), Giampaolo Tortora(Université Claude Bernard Lyon 1), Jörg Tost(Centre for Genomic Regulation), Yasushi Totoki(University of Göttingen), David Townend(University Health Network), Nadia Traficante(Tokyo Medical and Dental University), Isabelle Treilleux(Wellcome Sanger Institute), Jean-Rémi Trotta(University Hospitals Birmingham NHS Foundation Trust), Lorenz Trümper(Queen's University Belfast), Ming‐Sound Tsao(Oxford Nanopore Technologies (United Kingdom)), Tatsuhiko Tsunoda(Dana-Farber Cancer Institute), José M. C. Tubío(Wakayama Medical University), Olga Tucker(The University of Texas MD Anderson Cancer Center), Richard Turkington(Johns Hopkins University), Daniel J. Turner(Science for Life Laboratory), Andrew Tutt(University of Southampton), Masaki Ueno(European Bioinformatics Institute), Naoto T. Ueno, Christopher B. Umbricht(The University of Tokyo), Husen M. Umer(Tallinn University of Technology), Tim Underwood(Institució Catalana de Recerca i Estudis Avançats), Lara Urban(University of Southern California), Tomoko Urushidate(University of Antwerp), Tetsuo Ushiku(The Francis Crick Institute), Liis Uusküla-Reimand(Emory University), Alfonso Valencia(University of Antwerp), David Van Den Berg(University Health Network), Steven Van Laere(University of Leeds), Peter Van Loo(Norwegian University of Science and Technology), Erwin G. Van Meir(The University of Melbourne), Gert G. Van den Eynden(University of North Carolina at Chapel Hill), Theodorus van der Kwast(University of Toronto), Naveen Vasudev(Ghent University), Miguel Vazquez(University of Antwerp), Ravikiran Vedururu(University of Oxford), Umadevi Veluvolu, Shankar Vembu(Barcelona Supercomputing Center), Lieven P. C. Verbeke, Peter Vermeulen(Government of India), Clare Verrill(University of Latvia), Alain Viari(The University of Sydney), David Vicente(Barcelona Supercomputing Center), Caterina Vicentini(Inserm), K. VijayRaghavan(Tampere University Hospital), Juris Vīksna(Broad Institute), Ricardo E. Vilain(QIMR Berghofer Medical Research Institute), Izar Villasante(University of Cambridge), Anne Vincent‐Salomon(The University of Queensland), Tapio Visakorpi(The University of Queensland), Douglas Voet(Uppsala University), Paresh Vyas(Ontario Institute for Cancer Research), Ignacio Vázquez-Garćıa(Universität Ulm), Nick M. Waddell(Broad Institute), Nicola Waddell(BGI Group (China)), Claes Wadelius(James S. McDonnell Foundation), Lina Wadi(Baylor College of Medicine), Rabea Wagener(German Cancer Research Center), Jeremiah A. Wala(The University of Texas MD Anderson Cancer Center), Jian Wang(Baylor College of Medicine), Jiayin Wang(National Institutes of Health), Linghua Wang(The University of Melbourne), Qi Wang(Max Planck Institute for Molecular Genetics), Wenyi Wang(Yale University), Yumeng Wang(Cambridge University Hospitals NHS Foundation Trust), Zhining Wang(European Molecular Biology Laboratory), Paul Waring(University of Oxford), Hans-Jörg Warnatz(German Cancer Research Center), Jonathan Warrell(Augusta University), Anne Y. Warren(The University of Texas MD Anderson Cancer Center), Sebastian M. Waszak(European Molecular Biology Laboratory), David C. Wedge(University of Southern California), Dieter Weichenhan(Wythenshawe Hospital), Paul Weinberger(Washington University in St. Louis), John N. Weinstein(Leibniz Institute for Baltic Sea Research Warnemünde), Joachim Weischenfeldt(Centre for Human Genetics), Daniel J. Weisenberger(Baylor College of Medicine), Ian Welch(University College London), Michael C. Wendl(Mayo Clinic in Arizona), Johannes Werner(University of North Carolina at Chapel Hill), Justin P. Whalley(University of California San Diego), David A. Wheeler(The University of Sydney), Hayley C. Whitaker(Ontario Institute for Cancer Research), Dennis A. Wigle(Ontario Institute for Cancer Research), Matthew D. Wilkerson(Nationwide Children's Hospital), Ashley Williams(Mayo Clinic in Arizona), James S. Wilmott(University of Toronto), Gavin W. Wilson(Poznan University of Medical Sciences), Julie M. Wilson(German Cancer Research Center), Richard K. Wilson(National Cancer Centre Singapore), Boris Winterhoff(James S. McDonnell Foundation), Jeffrey A. Wintersinger(Washington University in St. Louis), Maciej Wiznerowicz(Electronics and Telecommunications Research Institute), Stephan Wolf(The University of Queensland), Bernice H. Wong(University of Toronto), Tina Wong(Ontario Institute for Cancer Research), Winghing Wong(MRC University of Glasgow Centre for Virus Research), Youngchoon Woo(Stanford University), Scott Wood(Massachusetts General Hospital), Bradly G. Wouters, A. Jordan Wright(Oregon Health & Science University), Derek Wright(Garvan Institute of Medical Research), Mark H. Wright(BGI Group (China)), Chin‐Lee Wu(Duke-NUS Medical School), Dai‐Ying Wu(Hong Kong University of Science and Technology), Guanming Wu(BGI Group (China)), Jianmin Wu(Huazhong University of Science and Technology), Kui Wu(Ontario Institute for Cancer Research), Yang Wu(New York Genome Center), Zhenggang Wu(Peking University), Xi Liu(BGI Group (China)), Tian Xia(The University of Queensland), Qian Xiang(Johns Hopkins University), Xiao Xiao(Hong Kong University of Science and Technology), Rui Xing(The University of Osaka), Heng Xiong(Heidelberg University), Qinying Xu, Yanxun Xu(Ontario Institute for Cancer Research), Hong Xue(Tokyo Women's Medical University), Shinichi Yachida(The University of Tokyo), Sergei Yakneen(Wakayama Medical University), Rui Yamaguchi(University of Toronto), Takafumi N. Yamaguchi(BGI Group (China)), Masakazu Yamamoto(The University of Sydney), Shogo Yamamoto(National Institutes of Health), Hiroki Yamaue(University of Chicago), Fan Yang(Hefei University of Technology), Huanming Yang(University of Cologne), Jean Yang(University of Toronto), Liming Yang(New York Genome Center), Lixing Yang(Max Planck Institute for Molecular Genetics), Shanlin Yang(Wellcome Sanger Institute), Tsun-Po Yang(Buck Institute for Research on Aging), Yang Yang(China National GeneBank), Xiaotong Yao(Xi'an Jiaotong University), Marie‐Laure Yaspo(Memorial Sloan Kettering Cancer Center), Lucy Yates(Korea Advanced Institute of Science and Technology), Christina Yau(Seoul National University Hospital), Chen Ye(Ontario Institute for Cancer Research), Kai Ye(Chinese University of Hong Kong), Venkata Yellapantula(The University of Texas MD Anderson Cancer Center), Christopher J. Yoon(Duke-NUS Medical School), Sung-Soo Yoon(Ruijin Hospital), Fouad Yousif(University of Glasgow), Jun Yu(NorthShore University HealthSystem), Kaixian Yu(Ontario Institute for Cancer Research), Willie Yu(Ontario Institute for Cancer Research), Yingyan Yu(Oslo University Hospital), Ke Yuan(Universidade de Santiago de Compostela), Yuan Yuan(German Cancer Research Center), Denis Yuen(National Institutes of Health), Christina K. Yung(National Center for Tumor Diseases), Olga Zaikova(Epworth Hospital), Jorge Zamora(Harvard University), Marc Zapatka(Peking University), Jean C. Zenklusen(Broad Institute), Thorsten Zenz(Second Military Medical University), Nikolajs Zeps(Memorial Sloan Kettering Cancer Center), Cheng‐Zhong Zhang(National Institutes of Health), Fan Zhang(Yale University), Hailei Zhang(Ontario Institute for Cancer Research), Hongwei Zhang(BGI Group (China)), Hongxin Zhang(The University of Texas Health Science Center at Houston), Jiashan Zhang(The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute), Jing Zhang(Peking University), Junjun Zhang(University of Houston), Xiuqing Zhang(Peking University), Xuanping Zhang(Peking University), Yan Zhang(Van Andel Institute), Zemin Zhang(BGI Group (China)), Zhongming Zhao(National Institutes of Health), Liangtao Zheng(The University of Texas MD Anderson Cancer Center), Xiuqing Zheng(University of California, Santa Cruz), Wanding Zhou(BGI Group (China)), Yong Zhou(Northwestern University), Bin Zhu(Wellcome Sanger Institute), Hongtu Zhu(Ontario Institute for Cancer Research), Jingchun Zhu(Royal Marsden NHS Foundation Trust), Shida Zhu(Erasmus MC), Lihua Zou(The University of Melbourne), Xueqing Zou(The Netherlands Cancer Institute), Anna DeFazio(SIB Swiss Institute of Bioinformatics), Nicholas van As, Carolien H. M. van Deurzen, Marc J. van de Vijver, L. van’t Veer, Christian von Mering
Cited by 234Open Access
Abstract
Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated genes with coding and non-coding mutations and revealed frequently mutated pathways and additional cancer genes with infrequent mutations. We also analyzed prognostic molecular pathways by integrating genomic and transcriptomic features of 1780 breast cancers and highlighted associations with immune response and anti-apoptotic signaling. Integration of ChIP-seq and RNA-seq data for master regulators of the Hippo pathway across normal human tissues identified processes of tissue regeneration and stem cell regulation. ActivePathways is a versatile method that improves systems-level understanding of cellular organization in health and disease through integration of multiple molecular datasets and pathway annotations.