The <i>parkin-coregulated gene</i> product PACRG promotes TNF signaling by stabilizing LUBAC

Jens Meschede(Ruhr University Bochum), Maria Šadič(Ludwig-Maximilians-Universität München), Nikolas Furthmann(Ruhr University Bochum), Tim Miedema(Ruhr University Bochum), Dominik A. Sehr(Ruhr University Bochum), Anne Kathrin Müller-Rischart(Ludwig-Maximilians-Universität München), Verian Bader(Ruhr University Bochum), Lena A. Berlemann(Ruhr University Bochum), Anna Pilsl(Ludwig-Maximilians-Universität München), Anita Schlierf(Ludwig-Maximilians-Universität München), Katalin Barkovits(Ruhr University Bochum), Barbara Kachholz(Ruhr University Bochum), Katrin Rittinger(The Francis Crick Institute), Fumiyo Ikeda(Institute of Molecular Biotechnology), Katrin Marcus(Ruhr University Bochum), Liliana Schaefer(Goethe University Frankfurt), Jörg Tatzelt(Ludwig-Maximilians-Universität München), Konstanze F. Winklhofer(Ludwig-Maximilians-Universität München)
Science Signaling
February 4, 2020
10.1126/scisignal.aav1256
Cited by 25Open Access
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Abstract

PACRG can functionally substitute for the LUBAC adaptor subunit SHARPIN to stimulate NF-κB signaling.

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