MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network

Giovanni Battista Migliori(Istituti Clinici Scientifici Maugeri), Simon Tiberi(Queen Mary University of London), Alimuddin Zumla(UCL Biomedical Research Centre), Eskild Petersen(Aarhus University), Jeremiah Chakaya(Kenyatta University), Christian Wejse(Aarhus University), Marcela Muñoz Torrico(Instituto Nacional de Enfermedades Respiratorias), Raquel Duarte(Universidade do Porto), Jan‐Willem C. Alffenaar(The University of Sydney), H. Simon Schaaf(Stellenbosch University), Ben J. Marais(The University of Sydney), Daniela María Cirillo(San Raffaele University of Rome), Riccardo Alagna(San Raffaele University of Rome), Adrián Rendón(Universidad Autónoma de Nuevo León), Emanuele Pontali(Ente Ospedaliero Ospedali Galliera), Alberto Piubello(International Union Against Tuberculosis and Lung Disease), José Natal Figueroa(National Health Service), Gabriella Ferlazzo(Médecins Sans Frontières), Alberto L. García‐Basteiro(Manhiça Health Research Centre), Rosella Centis(Istituti Clinici Scientifici Maugeri), Dina Visca(University of Insubria), Lia D’Ambrosio, Giovanni Sotgiu(University of Sassari), T. Abu Arkub, Onno W. Akkerman, Alena Aleksa, Evgeny Belilovski(Istituti Clinici Scientifici Maugeri), Enrique Bernal(Istituti Clinici Scientifici Maugeri), F.–X. Blanc, Martin J. Boeree(Ente Ospedaliero Ospedali Galliera), Borisov Se, Judith Bruchfeld(National Health Service), J. Cadiñanos Loidi(National Health Service), José A. Caminero(The University of Sydney), Anna Cristina Calçada Carvalho(Istituti Clinici Scientifici Maugeri), José Joaquín Cebrián Gallardo, Charalampos, Edvardas Danila(Istituti Clinici Scientifici Maugeri), Lina Davies Forsman(University of Sassari), Justin T. Denholm(National Health Service), Keertan Dheda(Kenyatta University), Roland Diel(Istituti Clinici Scientifici Maugeri), Saulius Diktanas, Claudia C. Dobler(University of Insubria), Martin Enwerem(Ente Ospedaliero Ospedali Galliera), Susanna Esposito, Nancy Salinas, Filippov Av, Beatrice Formenti(Manhiça Health Research Centre), José-María García-García(The University of Sydney), Delia Goletti, R. Gomez Rosso(Istituti Clinici Scientifici Maugeri), Gina Gualano, Petros Isaakidis(International Union Against Tuberculosis and Lung Disease), Anna Kaluzhenina, S Koirala, Līga Kukša(University of Sassari), Heinke Kunst(Stellenbosch University), Yawei LI, Cécile Magis-Escurra(University of Insubria), Vinicio Manfrin(University of Sassari), Selene Manga, K. Manika(Kenyatta University), Valentina Marchese(University of Sassari), Elena Martínez Robles(Istituti Clinici Scientifici Maugeri), А. O. Мaryandyshev, Alberto Matteelli, Alessandro Wasum Mariani, Jesica Mazza‐Stalder(National Health Service), Fernanda Carvalho de Queiroz Mello(Médecins Sans Frontières), Lourdes Milagros Mendoza(University of Sassari), A. Mesi, Skaidrius Miliauskas, H. Mustafa Hamdan(Stellenbosch University), Norbert Ndjeka, M. Nieto Marcos(Ente Ospedaliero Ospedali Galliera), T.H.M. Ottenhoff, Domingo Palmero, Fabrizio Palmieri(Médecins Sans Frontières), Apostolos Papavasileiou, M. C. Payen, Agostina Pontarelli, Margareth Pretti Dalcolmo(Ente Ospedaliero Ospedali Galliera), Sarai Quirós Fernández, R. Romero(Istituti Clinici Scientifici Maugeri), D. Rossato Silva, Adonis Pino Santos, Barbara Seaworth(Manhiça Health Research Centre), М. В. Синицын(Ente Ospedaliero Ospedali Galliera), Alena Skrahina, Ivan Solovič, Antonio Spanevello, Marina Tadolini(Ente Ospedaliero Ospedali Galliera), Chelseah Denise H. Torres(University of Insubria), Zarir Udwadia(Médecins Sans Frontières), Martin van den Boom(Ente Ospedaliero Ospedali Galliera), Grigory Volchenkov, Askar Yedilbayev, R. Zaleskis(Istituti Clinici Scientifici Maugeri), J.-P. Zellweger
International Journal of Infectious Diseases
February 13, 2020
10.1016/j.ijid.2020.01.042
Cited by 226Open Access
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Abstract

The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.

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