Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Nikos Papadimitriou(Centre international de recherche sur le cancer), Niki Dimou(Centre international de recherche sur le cancer), Konstantinos K. Tsilidis(University of Ioannina), Barbara L. Banbury(Fred Hutch Cancer Center), Richard M. Martin(University Hospitals Bristol NHS Foundation Trust), Sarah J. Lewis(University of Bristol), Nabila Kazmi(University of Bristol), Tim Robinson(University of Bristol), Demetrius Albanes(National Institutes of Health), Krasimira Aleksandrova(German Institute of Human Nutrition), Sonja I. Berndt(National Institutes of Health), D. Timothy Bishop(University of Leeds), Hermann Brenner(German Cancer Research Center), Daniel D. Buchanan(The Royal Melbourne Hospital), Bas Bueno‐de‐Mesquita(University Medical Center Utrecht), Peter T. Campbell(American Cancer Society), Sergi Castellvı́-Bel(Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas), Andrew T. Chan(Harvard University), Jenny Chang‐Claude(Universität Hamburg), Merete Ellingjord‐Dale(Imperial College London), Jane C. Figueiredo(University of Southern California), Steven Gallinger(Mount Sinai Hospital), Graham G. Giles(The University of Melbourne), Edward L. Giovannucci(Brigham and Women's Hospital), Stephen B. Gruber(University of Southern California), Andrea Gsur, Jochen Hampe(Technische Universität Dresden), Heather Hampel(The Ohio State University), Sophia Harlid(Umeå University), Tabitha A. Harrison(Fred Hutch Cancer Center), Michael Hoffmeister(German Cancer Research Center), John L. Hopper(The University of Melbourne), Li Hsu(University of Washington), José María Huerta(Instituto Murciano de Investigación Biosanitaria), Jeroen R. Huyghe(Fred Hutch Cancer Center), Mark A. Jenkins(The University of Melbourne), Temitope O. Keku(University of North Carolina at Chapel Hill), Tilman Kühn(German Cancer Research Center), Carlo La Vecchia(University of Milan), Loı̈c Le Marchand(University of Hawaiʻi at Mānoa), Christopher I. Li(Fred Hutch Cancer Center), Li Li(Mount Sinai Hospital), Annika Lindblom(Karolinska University Hospital), Noralane M. Lindor(Mayo Clinic in Arizona), Brigid M. Lynch(Baker Heart and Diabetes Institute), Sanford D. Markowitz(University Hospitals of Cleveland), Giovanna Masala(Piedmont Reference Center for Epidemiology and Cancer Prevention), Anne M. May(Utrecht University), Roger L. Milne(The University of Melbourne), Evelyn M. Monninkhof(Utrecht University), Lorena Moreno(Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas), Vı́ctor Moreno(Institut d'Investigació Biomédica de Bellvitge), Polly A. Newcomb(University of Washington), Kenneth Offit(Memorial Sloan Kettering Cancer Center), Vittorio Perduca(Université Paris-Sud), Paul D.P. Pharoah(University of Cambridge), Elizabeth A. Platz(Johns Hopkins University), John D. Potter(Fred Hutch Cancer Center), Gad Rennert(Technion – Israel Institute of Technology), Elio Ríboli(Imperial College London), María‐José Sánchez(Universidad de Granada), Stephanie L. Schmit(University of Southern California), Robert E. Schoen(University of Pittsburgh Medical Center), Gianluca Severi(Université Paris-Sud), Sabina Sieri(Fondazione IRCCS Istituto Nazionale dei Tumori), Martha L. Slattery(University of Utah), Mingyang Song(Harvard University), Catherine M. Tangen(Fred Hutch Cancer Center), Stephen N. Thibodeau(Mayo Clinic), Ruth C. Travis(University of Oxford), Antonia Trichopoulou(Hellenic Health Foundation), Cornelia M. Ulrich(University of Utah), Franzel J. B. van Duijnhoven(Wageningen University & Research), Bethany Van Guelpen(Umeå University), Pavel Vodička(Charles University), Emily White(University of Washington), Alicja Wolk(Karolinska Institutet), Michael O. Woods(Memorial University of Newfoundland), Anna H. Wu(University of Southern California), Ulrike Peters(University of Washington), Marc J. Gunter(Centre international de recherche sur le cancer), Neil Murphy(Centre international de recherche sur le cancer)
Nature Communications
January 30, 2020
10.1038/s41467-020-14389-8
Cited by 692Open Access
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Abstract

Abstract Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER +ve ) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

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