A Comprehensive Map of Intron Branchpoints and Lariat RNAs in Plants
Xiaotuo Zhang(Kunming University of Science and Technology), Yong Zhang(Fudan University), Taiyun Wang(Fudan University), Ziwei Li(Fudan University), Jinping Cheng(Fudan University), Haoran Ge(Fudan University), Qi Tang(Fudan University), Kun Chen(Kunming University of Science and Technology), Li Liu(Kunming University of Science and Technology), Chenyu Lu(Kunming University of Science and Technology), Junqiang Guo(Kunming University of Science and Technology), Binglian Zheng(Fudan University), Yun Zheng(Kunming University of Science and Technology)
Cited by 45Open Access
Abstract
), respectively. Features of plant BPs are highly similar to those in yeast and human, in that BPs are adenine-preferred and flanked by uracil-enriched sequences. Intriguingly, ∼20% of introns harbor multiple BPs, and BP usage is tissue-specific. Furthermore, 10,580 lariat RNAs accumulate in wild-type Arabidopsis plants, and most of these lariat RNAs originate from longer or retroelement-depleted introns. Moreover, the expression of these lariat RNAs is accompanied by the incidence of back-splicing of parent exons. Collectively, our results provide a comprehensive map of intron BPs and lariat RNAs in four plant species and uncover a link between lariat turnover and splicing.
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