AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes

Minke A.E. Rab(Utrecht University), Richard van Wijk(Utrecht University), Kendall Johnson(Arup Group (United States)), Gerard Pasterkamp(University Medical Center Utrecht), Victor Chubukov(Agios Pharmaceuticals (United States)), Penelope A. Kosinski(Agios Pharmaceuticals (United States)), Jeffrey Hixon(Q Therapeutics (United States)), Wouter W. van Solinge(Utrecht University), Stephanie van Straaten(Utrecht University), Brigitte A. van Oirschot(Utrecht University), Lenny Dang(Millennium Engineering and Integration (United States)), Charles Kung(Agios Pharmaceuticals (United States)), Eduard J. van Beers(Utrecht University)
Haematologica
January 23, 2020
Cited by 81


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