Perfect timing: circadian rhythms, sleep, and immunity — an NIH workshop summary

Jeffrey A. Haspel(Washington University in St. Louis), Ron C. Anafi(Canadian Sleep & Circadian Network), Marishka Brown(National Heart Lung and Blood Institute), Nicolas Cermakian(Douglas Mental Health University Institute), Christopher M. Depner(University of Colorado Boulder), Paula Desplats(University of California San Diego), Andrew E. Gelman(Washington University in St. Louis), Monika Haack(Beth Israel Deaconess Medical Center), Sanja Jelić(Columbia University), Brian Kim(Washington University in St. Louis), Aaron D. Laposky(National Institutes of Health), Yvonne Lee(Northwestern University), Emmanuel F. Mongodin(University of Maryland, Baltimore), Aric A. Prather(University of California, San Francisco), Brian J. Prendergast(University of Chicago), Colin Reardon(University of California, Davis), Albert C. Shaw(Yale University), Shaon Sengupta(Children's Hospital of Philadelphia), Éva Szentirmai(Washington State University Spokane), Mahesh Thakkar(St. Louis VA Medical Center), Wendy E. Walker(Texas Tech University), Laura A. Solt(Scripps Research Institute)
JCI Insight
January 15, 2020
10.1172/jci.insight.131487
Cited by 246Open Access
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Abstract

Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses - ranging from leukocyte mobilization, trafficking, and chemotaxis to cytokine release and T cell differentiation -are mediated in a time of day-dependent manner. The National Institutes of Health (NIH) recently sponsored an interdisciplinary workshop, "Sleep Insufficiency, Circadian Misalignment, and the Immune Response," to highlight new research linking sleep and circadian biology to immune function and to identify areas of high translational potential. This Review summarizes topics discussed and highlights immediate opportunities for delineating clinically relevant connections among biological rhythms, sleep, and immune regulation.

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