Metabolic inhibitors of bacterial glycan biosynthesis
Daniel Williams(Bowdoin College), Kabita Pradhan(Indian Institute of Technology Bombay), Ankita Paul(Indian Institute of Technology Bombay), Ilana R. Olin(Bowdoin College), Owen T. Tuck(Bowdoin College), Karen D. Moulton(Bowdoin College), Suvarn S. Kulkarni(Indian Institute of Technology Bombay), Danielle H. Dube(Bowdoin College)
Cited by 53Open Access
Abstract
. Strikingly, these inhibitors acted in a bacteria-selective manner. These metabolic inhibitors will provide a platform for systematic study of bacterial glycosylation enzymes not currently possible with existing tools. Moreover, their selectivity will provide a pathway for the development of novel, narrow-spectrum antibiotics to treat infectious disease. Our inhibition approach is general and will expedite the identification of bacterial glycan biosynthesis inhibitors in a range of systems, expanding the glycochemistry toolkit.
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