<i>N</i> <sup>6</sup> -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription
Jun Liu(Howard Hughes Medical Institute), Xiaoyang Dou(Howard Hughes Medical Institute), Chuanyuan Chen(Chinese Academy of Sciences), Chuanyuan Chen(Chinese Academy of Sciences), Chuan Chen(Howard Hughes Medical Institute), Chuan Chen(Chinese Academy of Sciences), Chang Liu(Howard Hughes Medical Institute), Meng Xu(Center for Life Sciences), Siqi Zhao(Chinese Academy of Sciences), Bin Shen(Chinese Academy of Sciences), Yawei Gao(Howard Hughes Medical Institute), Dali Han(Chinese Academy of Sciences), Chuan He(Howard Hughes Medical Institute)
Cited by 696Open Access
Abstract
A new layer of transcriptional control N 6 -methyladenosine (m 6 A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m 6 A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs) in mammalian cells. Disruption of m 6 A modification of these RNAs increases their abundance and promotes gene transcription by increasing the chromatin accessibility. Thus, m 6 A serves as a switch to regulate carRNA levels by tuning nearby chromatin state and downstream transcription. Science , this issue p. 580
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