Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors
Di Chen(University of California, Los Angeles), Na Sun(Broad Institute), Lei Hou(Broad Institute), Rachel Kim(University of California, Los Angeles), Jared Faith(University of California, Los Angeles), M. M. Aslanyan(University of California, Los Angeles), Yu Tao(University of California, Los Angeles), Yi Zheng(University of Michigan), Jianping Fu(University of Michigan), Wanlu Liu(Zhejiang University-University of Edinburgh Institute), Manolis Kellis(Broad Institute), Amander T. Clark(University of California, Los Angeles)
Cited by 201Open Access
Abstract
progenitors upstream of PRDM1 to regulate the expression of SOX17. This serves to protect hPGCLCs from crossing the Weismann's barrier to adopt somatic cell fates and, therefore, is an essential mechanism for successfully initiating in vitro gametogenesis.