Phytochemicals of garlic: Promising candidates for cancer therapy

Yan Zhang(Huazhong University of Science and Technology), Xingping Liu(Huazhong University of Science and Technology), Jun Ruan(Central China Normal University), Xuan Zhuang(First Affiliated Hospital of Xiamen University), Xinzong Zhang(Guangdong Provincial Family Planning Hospital), Zhiming Li(Huazhong University of Science and Technology)
Biomedicine & Pharmacotherapy
December 23, 2019
Cited by 180Open Access
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Abstract

Of the numerous health benefits of garlic, the anticancer effect is probably the most noticeable. Observations over the past years have shown that the consumption of garlic in the diet provides strong protection against cancer risk. Previous studies involving garlic phytochemicals have usually focused on the cancer chemopreventive properties, but there is little published evidence showing its therapeutic potential in cancer treatment. In view of the multitargeted carcinoma actions and lack of severe toxicity, some components of garlic are likely to play vital roles in the selective killing of cancer cells. However, the rational design of experimental studies and clinical trials are required to verify this concept. This paper discusses the promises and pitfalls of garlic for the treatment of cancer.


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