GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling
Vanessa A. N. Kraft(Helmholtz Zentrum München), Carla T. Bezjian(Columbia University), Susanne Pfeiffer(Helmholtz Zentrum München), Larissa Ringelstetter(Helmholtz Zentrum München), Constanze Müller(Helmholtz Zentrum München), Fereshteh Zandkarimi(Columbia University), Juliane Merl‐Pham(Helmholtz Zentrum München), Xuanwen Bao(Helmholtz Zentrum München), Nataša Anastasov(Helmholtz Zentrum München), Johanna Kössl(Helmholtz Zentrum München), Stefanie Brandner(Helmholtz Zentrum München), Jacob D. Daniels(Columbia University), Philippe Schmitt‐Kopplin(Helmholtz Zentrum München), Stefanie M. Hauck(Helmholtz Zentrum München), Brent R. Stockwell(Columbia University), Kamyar Hadian(Helmholtz Zentrum München), Joel Schick(Helmholtz Zentrum München)
Cited by 1,191Open Access
Abstract
, and peroxidation of unusual phospholipids with two polyunsaturated fatty acyl tails. This demonstrates a unique mechanism of ferroptosis protection that is independent of the GPX4/glutathione system.
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