LncRNA <i>PTPRE-AS1</i> modulates M2 macrophage activation and inflammatory diseases by epigenetic promotion of PTPRE

Xiao Han; Saihua Huang; Saihua Huang; Ping Xue; Jinrong Fu; Lijuan Liu; Caiyan Zhang; Lan Yang; Li Xia; Licheng Sun; Shau-Ku Huang; Shau-Ku Huang; Yufeng Zhou

doi:10.1126/sciadv.aax9230

LncRNA <i>PTPRE-AS1</i> modulates M2 macrophage activation and inflammatory diseases by epigenetic promotion of PTPRE

Xiao Han(Fudan University), Saihua Huang(Johns Hopkins University), Saihua Huang(Johns Hopkins University), Ping Xue(Children's Hospital of Fudan University), Jinrong Fu(Children's Hospital of Fudan University), Lijuan Liu(Children's Hospital of Fudan University), Caiyan Zhang(Children's Hospital of Fudan University), Lan Yang(Children's Hospital of Fudan University), Li Xia(Children's Hospital of Fudan University), Licheng Sun(Johns Hopkins University), Shau-Ku Huang(Johns Hopkins University), Shau-Ku Huang(Johns Hopkins University), Yufeng Zhou(Fudan University)

Science Advances

December 6, 2019

10.1126/sciadv.aax9230

Cited by 128Open Access

Full Text

Abstract

PTPRE-AS1 deficiency aggravates pulmonary inflammation but reduces colitis severity by modulating M2 macrophage activation.

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