The antimicrobial peptide ZY4 combats multidrug-resistant <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> infection

James Mwangi(Kunming Institute of Zoology), Yizhu Yin(Kunming Institute of Zoology), Wang Gan(Kunming Institute of Zoology), Min Yang(Kunming Institute of Zoology), Ya Li(Kunming Medical University), Zhiye Zhang(Kunming Institute of Zoology), Ren Lai(Chinese University of Hong Kong)
Proceedings of the National Academy of Sciences
December 16, 2019
10.1073/pnas.1909585117
Cited by 285Open Access
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Abstract

Significance This work showed that a designed cyclic peptide ZY4 exhibits excellent activity against Pseudomonas aeruginosa and Acinetobacter baumannii . ZY4 not only inhibits planktonic growth and biofilm formation but also kills persister cells by permeabilizing bacterial membrane. ZY4 showed low propensity to induce resistance, high stability in vivo, and therapeutic potentials in MDR P. aeruginosa – and A. baumannii –induced infection. The present study provides a promising drug candidate in the war against multidrug resistance.

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